Antiproliferative Activity of Acerogenin C, a Macrocyclicdiarylheptanoid, on PDGF-Induced Human Aortic Smooth Muscle Cells Proliferation
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53906#.VNsH6izQrzE Author(s) Byung-Yoon Cha 1 , Wen Lei Shi 2 , Kotaro Watanabe 3 , Takayuki Yonezawa 1 , Toshiaki Teruya 1 , Kiyotake Kiyotake 3 , Yuichi Ishikawa 3 , Shigeru Nishiyama 3 , Kazuo Nagai 1,2 , Je-Tae Woo 1,2 Affiliation(s) 1 Research Institute for Biological Functions, Chubu University, Matsumoto, Japan . 2 Department of Biological Chemistry, Chubu University, Matsumoto, Japan . 3 Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan . ABSTRACT Platelet-derived growth factor (PDGF)-BB is one of the most potent factors in the development and progression of various vascular disorders, such as atherosclerosis and restenosis. PDGF is a major stimulant for vascular smooth muscle cells (VSMCs) proliferation via the mitogenesis signaling pathway. In the present study, we investigated the effect of ace...