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博文

目前显示的是标签为“Lithium”的博文

Psychiatric Symptoms of Epileptic Nature: An Old Hypothesis in Light of Current Psychopharmacologic Advances

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53672#.VM8uUyzQrzE Author(s)    Javier Alvarez-Rodriguez Affiliation(s) Departamento de Psiquiatría, Complejo Asistencial Universitario de León, León, Spain . ABSTRACT This paper analyses a hypothesis according to which many positive psychiatric symptoms should be interpreted as symptoms of epileptic nature. When we first raised this proposition, almost fifteen years ago, it was inconsistent with the widespread conviction among psychiatrists that psychopharmacological drugs used to suppress psychiatric symptoms were proconvulsant. But lately, there have appeared numerous neuroscientific investigations that defend the anticonvulsant effect of most psychopharmacological drugs, hence supporting our hypothesis. We have carried out bibliographical reviews in search of the pro- or anticonvulsant role of these substances, particularly lithium, selective ser...

Effects of Imipramine and Lithium on the Expression of Hippocampal Wnt 3a and Cyclin D1 in ACTH-Treated Rats

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51399#.VGlU72fHRK0 Author(s) Yoshihisa Kitamura 1* , Hiromi Hayashi 1 , Yuka Onoue 1 , Keiko Kuwatsuka 1 , Ayaka Miyake 1 , Ikuko Miyazaki 2 , Masato Asanuma 2 , Toshiaki Sendo 1 Affiliation(s) 1 Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan . 2 Department of Brain Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan . ABSTRACT We have shown previously that chronic administration of adrenocorticotropic hormone (ACTH) causes a significant decrease in hippocampal cell proliferati...