跳至主要内容

Effects of Imipramine and Lithium on the Expression of Hippocampal Wnt 3a and Cyclin D1 in ACTH-Treated Rats

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51399#.VGlU72fHRK0

We have shown previously that chronic administration of adrenocorticotropic hormone (ACTH) causes a significant decrease in hippocampal cell proliferation and neurogenesis. This effect in rats treated chronically with ACTH was not influenced by the chronic administration of imipramine, but was reversed by coadministration of imipramine and lithium. The present study was undertaken to further characterize the mechanism underlying the effect of imipramine and lithium on hippocampal cell proliferation and neurogenesis, by investigating the effects of treatment on the expression of brain-derived neurotrophic factor (BDNF), total cyclic adenosine monophosphate response element-binding protein (CREB), and phosphorylated CREB (pCREB) of the CREB signaling system, as well as Wnt 3a and cyclin D1 of the Wnt signaling pathway in the hippocampus of saline- and ACTH-treated rats. ACTH treatment significantly decreased the expression of cyclin D1. Treatment with imipramine and lithium increased the expression of cyclin D1 in ACTH-treated rats. However, the expression of BDNF, CREB, pCREB, and Wnt 3a did not change in either saline-treated or ACTH-treated rats. These findings suggest that the antidepressant effect of imipramine and lithium in ACTH-treatment-resistant rats may be attributed, at least in part, to an enhancement of cyclin D1 expression.
Cite this paper
Kitamura, Y. , Hayashi, H. , Onoue, Y. , Kuwatsuka, K. , Miyake, A. , Miyazaki, I. , Asanuma, M. and Sendo, T. (2014) Effects of Imipramine and Lithium on the Expression of Hippocampal Wnt 3a and Cyclin D1 in ACTH-Treated Rats. Journal of Behavioral and Brain Science, 4, 483-490. doi: 10.4236/jbbs.2014.411048. 
 

[1] Kitamura, Y., Araki, H. and Gomita, Y. (2002) Influence of ACTH on the Effects of Imipramine, Desipramine and Lithium on Duration of Immobility of Rats in the Forced Swim Test. Pharmacology, Biochemistry and Behavior, 71, 63-69.
http://dx.doi.org/10.1016/S0091-3057(01)00625-6
[2] Fink, M. (1990) How Does Convulsive Therapy Work? Neuropsychopharmacology, 3, 73-82.
[3] Li, B., Suemaru, K., Cui, R., Kitamura, Y., Gomita, Y. and Araki, H. (2006) Repeated Electroconvulsive Stimuli Increase Brain-Derived Neurotrophic Factor in ACTH-Treated Rats. European Journal of Pharmacology, 529, 114-121.
http://dx.doi.org/10.1016/j.ejphar.2005.11.009
[4] Fuchs, E., Czeh, B. and Flugge, G. (2004) Examining Novel Concepts of the Pathophysiology of Depression in the Chronic Psychosocial Stress Paradigm in Tree Shrews. Behavioural Pharmacology, 15, 315-325.
http://dx.doi.org/10.1097/00008877-200409000-00003
[5] Malberg, J.E. and Duman, R.S. (2003) Cell Proliferation in Adult Hippocampus Is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment. Neuropsycho-pharmacology, 28, 1562-1571.
http://dx.doi.org/10.1038/sj.npp.1300234
[6] Kodama, M., Fujioka, T. and Duman, R.S. (2004) Chronic Olanzapine or Fluoxetine Administration Increases Cell Proliferation in Hippocampus and Prefrontal Cortex of Adult Rat. Biological Psychiatry, 56, 570-580.
http://dx.doi.org/10.1016/j.biopsych.2004.07.008
[7] Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., Belzung, C. and Hen, R. (2003) Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants. Science, 301, 805-809.
http://dx.doi.org/10.1126/science.1083328
[8] Doi, M., Miyazaki, I., Nagamachi, T., Shinomiya, K., Matsunaga, H., Sendo, T., Kawasaki, H., Asanuma, M., Gomita, Y. and Kitamura, Y. (2010) Effects of Imipramine and Lithium on the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in Adrenocorticotropic Hormone-Treated Rats. Acta Medica Okayama, 64, 219-223.
[9] Kitamura, Y., Doi, M., Kuwatsuka, K., Onoue, Y., Miyazaki, I., Shinomiya, K., Koyama, T., Sendo, T., Kawasaki, H., Asanuma, M. and Gomita, Y. (2011) Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats. Biological and Pharmaceutical Bulletin, 34, 77-81.
http://dx.doi.org/10.1248/bpb.34.77
[10] Pencea, V., Bingaman, K.D., Wiegand, S.J. and Luskin, M.B. (2001) Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus. Journal of Neuroscience, 21, 6706-6717.
[11] Schinder, A.F., Berninger, B. and Poo, M. (2000) Postsynaptic Target Specificity of Neurotrophin-Induced Presynaptic potentiation. Neuron, 25, 151-163.
http://dx.doi.org/10.1016/S0896-6273(00)80879-X
[12] Duman, R.S. and Monteggia, L.M. (2006) A Neurotrophic Model for Stress-Related Mood Disorders. Biological Psychiatry, 59, 1116-1127.
http://dx.doi.org/10.1016/j.biopsych.2006.02.013
[13] Post, R.M. (2007) Role of BDNF in Bipolar and Unipolar Disorder: Clinical and Theoretical Implications. Journal of Psychiatric Research, 41, 979-990.
http://dx.doi.org/10.1016/j.jpsychires.2006.09.009
[14] Kuipers, S.D., Trentani, A., van der Zee, E.A. and den Boer, J.A. (2013) Chronic Stress-Induced Changes in the Rat Brain: Role of Sex Differences and Effects of Long-Term Tianeptine Treatment. Neuropharmacology, 75, 426-436.
http://dx.doi.org/10.1016/j.neuropharm.2013.08.018
[15] Baldin, V., Lukas, J., Marcote, M.J., Pagano, M. and Draetta, G. (1993) Cyclin D1 Is a Nuclear Protein Required for Cell Cycle Progression in G1. Genes and Development, 7, 812-821.
http://dx.doi.org/10.1101/gad.7.5.812
[16] Matsushime, H., Quelle, D.E., Shurtleff, S.A., Shibuya, M., Sherr, C.J. and Kato, J.Y. (1994) D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells. Molecular and Cellular Biology, 14, 2066-2076.
[17] Meirmanov, S., Nakashima, M., Kondo, H., Matsufuji, R., Takamura, N., Ishigaki, K., Ito, M., Prouglo, Y., Yamashita, S. and Sekine, I. (2003) Correlation of Cytoplasmic Beta-Catenin and Cyclin D1 Overexpression during Thyroid Carcinogenesis around Semipalatinsk Nuclear Test Site. Thyroid, 13, 537-545.
http://dx.doi.org/10.1089/105072503322238791
[18] Nakashima, M., Meirmanov, S., Naruke, Y., Kondo, H., Saenko, V., Rogounovitch, T., Shimizu-Yoshida, Y., Takamura, N., Namba, H., Ito, M., Abrosimov, A., Lushnikov, E., Roumiantsev, P., Tsyb, A., Yamashita, S. and Sekine, I. (2004) Cyclin D1 Overexpression in Thyroid Tumours from a Radio-Contaminated Area and Its Correlation with Pin1 and Aberrant Beta-Catenin Expression. Journal of Pathology, 202, 446-455.
http://dx.doi.org/10.1002/path.1534
[19] Nelson, W.J. and Nusse, R. (2004) Convergence of Wnt, Beta-Catenin, and Cadherin Pathways. Science, 303, 1483-1487.
http://dx.doi.org/10.1126/science.1094291
[20] Lee, S.M., Tole, S., Grove, E. and McMahon, A.P. (2000) A Local Wnt-3a Signal Is Required for Development of the Mammalian Hippocampus. Development, 127, 457-467.
[21] Chen, A.C., Shin, K.H., Duman, R.S. and Sanacora, G. (2001) ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated by Ketamine Pretreatment. Journal of ECT, 17, 27-32.
http://dx.doi.org/10.1097/00124509-200103000-00006
[22] Kuwatsuka, K., Hayashi, H., Onoue, Y., Miyazaki, I., Koyama, T., Asanuma, M., Kitamura, Y. and Sendo, T. (2013) The Mechanisms of Electroconvulsive Stimuli in BrdU-Positive Cells of the Dentate Gyrus in ACTH-Treated Rats. Journal of Pharmacological Sciences, 122, 34-41.
http://dx.doi.org/10.1254/jphs.13015FP
[23] Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R. and Ben-Ze’ev, A. (1999) The Cyclin D1 Gene Is a Target of the Beta-Catenin/LEF-1 Pathway. Proceedings of the National Academy of Sciences of the United States of America, 96, 5522-5527.
http://dx.doi.org/10.1073/pnas.96.10.5522
[24] Tetsu, O. and McCormick, F. (1999) Beta-Catenin Regulates Expression of Cyclin D1 in Colon Carcinoma Cells. Nature, 398, 422-426.
http://dx.doi.org/10.1038/18884
[25] Kumar, D.U. and Devaraj, H. (2012) Expression of Wnt 3a, Beta-Catenin, Cyclin D1 and PCNA in Mouse Dentate Gyrus Subgranular Zone (SGZ): A Possible Role of Wnt Pathway in SGZ Neural Stem Cell Proliferation. Folia Biologica, 58, 115-120.
[26] Gould, T.D., Einat, H., Bhat, R. and Manji, H.K. (2004) AR-A014418, a Selective GSK-3 Inhibitor, Produces Antidepressant-Like Effects in the Forced Swim Test. International Journal of Neuropsychopharmacology, 7, 387-390.
http://dx.doi.org/10.1017/S1461145704004535
[27] Jope, R.S. and Johnson, G.V. (2004) The Glamour and Gloom of Glycogen Synthase Kinase-3. Trends in Biochemical Sciences, 29, 95-102.
http://dx.doi.org/10.1016/j.tibs.2003.12.004
[28] Takahashi-Yanaga, F. and Sasaguri, T. (2007) The Wnt/Beta-Catenin Signaling Pathway as a Target in Drug Discovery. Journal of Pharmacological Sciences, 104, 293-302.
http://dx.doi.org/10.1254/jphs.CR0070024
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文