Antipsychotic Medication and Risk of QTc Prolongation: Focus on Multiple Medication and Role of Cytochrome P450 Isoforms
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50717#.VEmpg1fHRK0 Author(s) Takashi Ikeno 1,2* , Kiyotaka Kugiyama 2 , Hiroto Ito 1,2 Affiliation(s) 1 Department of Social Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan . 2 Faculty of Medicine, Graduate School of Medical Science, University of Yamanashi, Yamanashi, Japan . ABSTRACT Objective: To identify the effects of antipsychotics on QTc prolongation in light of age, gender, antipsychotic combination pattern, antipsychotic doses and cytochrome P450 (CYP) mediation, using large database describing the antipsychotic treatment of patients with schizophre...