Genotoxic and Cytotoxic Damage by Cyclophosphamide and Adriamycin as a Response to Treatment in Breast Cancer Patients: Pilot Study
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53822#.VNR6JSzQrzE Author(s) Jimena Garibay-Garcia 1 , Fernando Mejia-Sanchez 1 , Eduardo Ramírez-San-Juan 2 , Miriam V. Flores-Merino 1 , Julieta Castillo-Cadena 1 Affiliation(s) 1 Research Center in Medical Science, Autonomous University of the State of Mexico, Toluca, Mexico . 2 National School in Biological Science, Instituto Politécnico Nacional, Mexico City, Mexico . ABSTRACT The aim of this study was to evaluate the genotoxicity induced by cyclophosphamide-adriamycin treatment in breast cancer patients through the frequencies of Sister Chromatid Exchange (SCE), Replication Index (RI), Mitotic Index (MI) and Cell Proliferation Index (CPI) and to study the possible association between biomarkers of genotoxicity and the early response to treatment. The frequencies were obtained before and immediately after therapy from 17 patients with breas...