Evaluation of the Effect of Aspirin on Platelet Aggregation: Methodological Recommendations for Aspirin-Drug Interaction Studies
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53335#.VL3H3SzQrzE Author(s) Annelieke C. Kruithof 1* , Matthijs Moerland 1* , Eleftheria A. Anastasopoulou 1 , Pieter-Jan de Kam 2 , Marieke L. de Kam 3 , Jacobus Burggraaf 1 Affiliation(s) 1 Department of Vascular Medicine, Centre for Human Drug Research, Leiden, The Netherlands . 2 Department of Clinical Pharmacology, Merck Sharp & Dohme Corp., Rahway, USA . 3 Department of Pharmacometrics, Centre for Human Drug Research, Leiden, The Netherlands . ABSTRACT Given the broad application of aspirin as antiplatelet drug, availability of standardized methodology to assess potential interaction with any co-medication on platelet aggregation is desired. We characterized the effect of aspirin (ASA) therapy on collagen-induced platelet aggregation in whole blood to define such methodology. Collagen-induced platelet whole blood aggregation was assessed in...