Synthesis of Novel Fluorine Substituted Isolated and Fused Heterobicyclic Nitrogen Systems Bearing 6-(2’-Phosphorylanilido)-1,2,4-Triazin-5-One Moiety as Potential Inhibitor towards HIV-1 Activity

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Author(s)

Reda M. Abdel-Rahman, Mohammed S. T. Makki, Abeer N. Al-Romaizan^*

Affiliation(s)

Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, KSA.

ABSTRACT

Novel 6-(5’-fluoro-2’-diphenylphosphorylanilido)-3-hydrazino-1,2,4-trizin-5 (2H) one (3) is achieved from hydrozinolysis of the corresponding 3-thioxo-analoges 2. Compound 2 is also obtained from phosphorylation of 6-(5’-fluoro-2’-aminophenyl)-3-thioxo-1,2,4-triazin-5(2H) one (1). Novel fluorine substituted isolated and/or fused heterobicyclic nitrogen systems bearing and/or containing, 6-phosphoryl anilido-1,2,4-trizin-5 (2H) one moiety (4 - 22) have been synthesized from ring closure reactions of compound 3 with π-acceptors activated carbon compounds in different medium and conditions. Structures of the products are characterized by MS, IR, UV-VIS, CH, N, and 1H/13CNMR spectral data. The new products have been evaluated as potential inhibitors towards HIV-1 activity.

KEYWORDS

Synthesis, Fluorine, Phosphorus, Sulfar 1, 2, 4-Trizinones HIV-1

Cite this paper

Abdel-Rahman, R. , Makki, M. and Al-Romaizan, A. (2014) Synthesis of Novel Fluorine Substituted Isolated and Fused Heterobicyclic Nitrogen Systems Bearing 6-(2’-Phosphorylanilido)-1,2,4-Triazin-5-One Moiety as Potential Inhibitor towards HIV-1 Activity. International Journal of Organic Chemistry, 4, 247-268. doi: 10.4236/ijoc.2014.44028. 

 

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