Total joint arthroplasty (TJA) is a surgical procedure in which parts of an arthritic or damaged joint are removed and replaced with a metal, plastic or ceramic device called a prosthesis. In the USA, more than 500,000 total joint arthroplasty (TJA) operations. Though the technical advances, many patients still require surgical revision for aseptic loosening (AL) and/or bone loss due to osteolysis. There are two monocyte populations in human blood: CD14 + CD16 - classical monocytes and CD14 + CD16 + inflammatory monocytes. CD14 + CD16 + inflammatory monocytes, which account for approximately 10% of the total monocytes, may be expanded in various types of inflammatory conditions. The purpose of this study was to investigate whether the expansion of the CD14 + CD16 + monocyte population represented a risk factor of aseptic loosening (AL). In this study, peripheral monocytes subsets were measured in revision patients with AL (n = 35) and in patients with stable impla
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