跳至主要内容

Hypochlorous Acid for Septic Abdominal Processes Using a Unique Negative Pressure Wound Therapy System

Open abdomen is an abdominal wall defect created by intentionally leaving an abdominal incision open at the completion of intra-abdominal surgery or by opening (or reopening) the abdomen. Open abdomen can also be the result of injuries to the abdominal wall that produce significant soft tissue defects. Currently, multiple concentrations of hypochlorous (HOCL) acid solutions have effectively decreased the microbiotic burden in wounds.

In this paper, the authors hypothesized that Vashe®, a neutral hypochlorous acid solution (V-HOCL), would be safe as an intraperitoneal irrigation or washout disinfectant for septic open abdomens utilizing negative pressure wound therapy. They conducted a retrospective observational pilot study (January 2017-January 2018) to determine the feasibility of utilizing V-HOCL as a washout or irrigant for septic open abdomen. Hypochlorous acid was used in surgical patients with either open abdomens who required abdominal washouts during surgery or who required more intensive irrigation treatment with negative pressure wound therapy for a longer term. Group A (n = 8) had cyclical V-HOCL irrigation to their open abdomens combining AbtheraTM and V.A.C. Dressing System for negative pressure wound therapy with irrigation (NPWT-i) and Group B (n = 9) had intra-abdominal V-HOCL washouts. 

The results showed that fifty percent of both groups had either septic or hemorrhagic shock on admission. Compared to Group B, Group A patients were older (median 50 vs 37 years), and had a median hospitalization of 28 vs 8 days, 4 times as many operations, more acute renal failure and co-morbidities. No statistically significant differences were detected be-tween the two treatment methods with the V-HOCL delivery and removal. 

In conclusion, this pilot study has shown that Vashe®, a 0.033% hypochlorous acid in normal saline solution is safe as a standard surgical intra-abdominal washout or NPWT-i irrigant using the combination of the AbtheraTM device and V.A.C. Dressing SystemTM for septic open abdomens. In patients requiring an exploratory laparotomy and possibly an open abdomen for continuous irrigation or a single washout of the abdomen, these interventions may provide a benefit to the patient with a septic open abdomen.


Article by Marc R. Matthews, et al, from USA.

Full access: http://mrw.so/4FE5iM

评论

发表评论

此博客中的热门博文

Incorporation of High-Altitude Balloon Experiment in High School Science Classrooms

High-altitude balloon is a balloon, filled usually with helium or hydrogen that ascends into an area called “near space” or stratosphere. The most common type of high-altitude balloons are weather balloons. Other purposes include use as a platform for experiments in the upper atmosphere. Modern balloons generally contain electronic equipment such as radio transmitters, cameras, or satellite navigation systems, such as GPS receivers. The mission of the High-Altitude Balloon Experiment (HABE) is to acquire supporting data, validate enabling technologies, and resolve critical acquisition, tracking, and pointing (ATP) and fire control issues in support of future space-based precision pointing experiments. The use of high-altitude balloons offers a relatively low-cost, low-vibration test platform, a recoverable and reusable payload, worldwide launch capability, and a 'near- space' emulation of the future space systems operational scenarios. More recently, several university...
1 条评论
阅读全文

Location Optimization of a Coal Power Plant to Balance Costs against Plant’s Emission Exposure

Fuel and its delivery cost comprise the biggest expense in coal power plant operations. Delivery of electricity from generation to consumers requires investment in power lines and transmission grids. Placing a coal power plant or multiple power plants near dense population centers can lower transmission costs. If a coalmine is nearby, transportation costs can also be reduced. However, emissions from coal plants play a key role in worsening health crises in many countries. And coal upon combustion produces CO 2 , SO 2 , NO x , CO, Metallic and Particle Matter (PM10 & PM2.5). The presence of these chemical compounds in the atmosphere in close vicinity to humans, livestock, and agriculture carries detrimental health consequences. The goal of the research was to develop a methodology to minimize the public’s exposure to harmful emissions from coal power plants while maintaining minimal operational costs related to electric distribution losses and coal logistics. The objective was...
发表评论
阅读全文

The Influence of Heated Soil in Crop of “Tamaris” Tomato Plants on the Biological Activity of the Rhizosphere Soil

Tomato is a plant with high heat requirements and sensitive to cold weather and frost. The optimum temperature for the growth of tomato plants is between 21˚C and 27˚C during the day and between 17˚C and 21˚C at night. The soil temperature is also very important for plant growth. The optimum soil temperature for tomato cultivation should be within the range 15˚C - 18˚C. Besides, the proper development of the root system depends on the optimal temperature of the soil. A temperature below 14˚C reduces and inhibits the growth of the root system and encourages the development of fungal and bacterial diseases. In this study, the authors aimed to evaluate the effect of heated soil on the population of bacteria, fungi and nematodes inhabiting the soil of tomato cultivar “Tamaris” growing in peat and coconut substrates. The experiment was carried out in 12 treatments and in 3 replications (one slab was one replication). The soils were tested in two different types of containers: cylinders...
发表评论
阅读全文