Antibodies are proteins produced from B-lymphocytes when antigens
invade the body. They remove and inactivate foreign substances together with
various agents, including complements. They have become an important focus in
post genome research. They are being applied in a wide range of therapeutics
and diagnosis for conditions such as pregnancy and influenza infection, and as
anticancer drugs targeting specific tumor markers. The result has been an
increasing use of antibodies for research, diagnosis, and therapeutic purposes.
Unfortunately, antibodies from experimental mammals such as mice, rats, and
rabbits, are not suited to industrial use because of their high production
cost.
Some studies have shown that the ostrich egg is an excellent source
of antibodies for industrial purposes. In this article, the authors discussed the
practical application of ostrich antibodies, by which means we have established
low-cost mass-production technology to create skin care raw materials.
The report showed that the ostrich antibodies had therapeutic effects
in ailments such as atopic dermatitis, acne, pyoderma, and pollen allergies. The
authors have successfully produced and purified ostrich immunoglobulin yolk
(IgY) against pollen allergens (Cryj1, Cryj2, Chao1, Chao2) and found that
allergic reactions were alleviated in skin patch tests of allergic patients by
using the ostrich IgY. In addition, the authors produced ostrich IgY against
the homogenates of Staphylococcus aureus and Propionibacterium
acnes, and applied to dermal lesions of atopic dermatitis and acne patients,
and then observed the therapeutic effects on the dermatitis of volunteer
subjects. Antibody against S. aureus also had the therapeutic
effect on canine pyoderma caused by MRSA.
In conclusion, the results indicate that a particular advantage in
using ostrich antibodies is the fact that they inactivate and neutralize a
specific antigen, without damaging the indigenous microflora of the dermal
surface and suggest that ostrich antibodies can contribute to the treatment of
cutaneous disorders as an alternative to treatment with steroids or
antibiotics.
Article by Yasuhiro Tsukamoto, et al, from
Japan, China and USA.
Full access: http://mrw.so/59FLqF
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