跳至主要内容

Intraoperative Bleeding Associated with Preoperative Use of Ganoderma lucidum Supplements

Reishi mushroom, also known as Ganoderma lucidum, is a type of edible medicinal fungi that is found throughout Asia. The fruiting body (above-ground part) and mycelium (filaments connecting a group of mushrooms) are used as medicine. Recent research has shown that it may also have antiplatelet activity that is similar to aspirin. Likewise simvastatin has been shown to inhibit platelet aggregation. In addition, montelukast has anecdotally related to one case of acquired thrombopathia and may interfere with platelet aggregation.

In this paper, the authors reported a case of intraoperative hemorrhage with laparoscopic trocar placement and dissection in a patient concomitantly taking Ganoderma lucidum supplements, simvastatin and montelukast, all of which had a possible anticoagulant effect. The patient was a 64-year-old Vietnamese female. Patient had a past medical history of asthma, hypertension and dyslipidemia for which she took montelukast, albuterol, captopril and simvastatin. And she denied taking any supplements. Her preoperative coagulation studies were all within normal limits as the prothrombin time was 12.7 (control 12.1 - 14.8), partial thrombolplastin time was 34.0 (control 24.0 - 34.2) and the INR was 0.9. Her preoperative platelet count was 219,000. After surgery, she had post-operative bleeding from the wound edges that required cautery for hemostasis, which the surgeons believed was consistent with a platelet defect. She had no other further episodes of bleeding. Postoperatively, upon further questioning, she admitted to have been taking two Ganoderma products which she had denied to the involved clinicians preoperatively. And finally, the authors hypothesized that the patient’s platelets may have had a qualitative platelet defect because of the simultaneous use of montelukast, simvastatin and ganoderma supplements. More patients are utilizing herbal. 

In short, Reishi Mushroom products should be taken with caution in patients before surgery especially those who are taking other drugs with anti-platelet effects. It’s believed that a reasonable precaution would be to avoid the use of Ganoderma lucidum products for seven days prior to surgery if the patient is also taking simvastatin, montelukast or an anticoagulant.


Article by Steven Shulman, et al, from Rutgers New Jersey Medical School, Newark, USA.

Full access: http://mrw.so/5pQ5Lp

Image by Urmas Ojango, from Flickr-cc.

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文

Electron Spin and Proton Spin in the Hydrogen and Hydrogen-Like Atomic Systems

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52202#.VIj7tMnQrzE Author(s) Stanisław Olszewski * Affiliation(s) Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland . ABSTRACT The mechanical angular momentum and magnetic moment of the electron and proton spin have been calculated semiclassically with the aid of the uncertainty principle for energy and time. The spin effects of both kinds of the elementary particles can be expressed in terms of similar formulae. The quantization of the spin motion has been done on the basis of the old quantum theory. It gives a quantum number n = 1/2 as the index of the spin state acceptable for both the electron and proton ...
发表评论
阅读全文