Reishi
mushroom, also known as Ganoderma lucidum, is a type of edible
medicinal fungi that is found throughout Asia. The fruiting body (above-ground
part) and mycelium (filaments connecting a group of mushrooms) are used as
medicine. Recent research has shown that it may also have antiplatelet activity
that is similar to aspirin. Likewise simvastatin has been shown to inhibit
platelet aggregation. In addition, montelukast has anecdotally related to one
case of acquired thrombopathia and may interfere with platelet aggregation.
In this paper, the authors reported a case of intraoperative
hemorrhage with laparoscopic trocar placement and dissection in a patient
concomitantly taking Ganoderma lucidum
supplements, simvastatin and montelukast, all of which had a possible
anticoagulant effect. The patient was a 64-year-old Vietnamese female. Patient
had a past medical history of asthma, hypertension and dyslipidemia for which
she took montelukast, albuterol, captopril and simvastatin. And she denied
taking any supplements. Her preoperative coagulation studies were all within
normal limits as the prothrombin time was 12.7 (control 12.1 - 14.8), partial
thrombolplastin time was 34.0 (control 24.0 - 34.2) and the INR was 0.9. Her
preoperative platelet count was 219,000. After surgery, she had post-operative
bleeding from the wound edges that required cautery for hemostasis, which the
surgeons believed was consistent with a platelet defect. She had no other
further episodes of bleeding. Postoperatively, upon further questioning, she
admitted to have been taking two Ganoderma products which she had denied to the
involved clinicians preoperatively. And finally, the authors hypothesized that the
patient’s platelets may have had a qualitative platelet defect because of the
simultaneous use of montelukast, simvastatin and ganoderma supplements. More
patients are utilizing herbal.
In short, Reishi Mushroom products should be taken with caution in
patients before surgery especially those who are taking other drugs with
anti-platelet effects. It’s believed that a reasonable precaution would be to
avoid the use of Ganoderma lucidum
products for seven days prior to surgery if the patient is also taking
simvastatin, montelukast or an anticoagulant.
Article by Steven
Shulman, et al, from Rutgers New Jersey
Medical School, Newark, USA.
Full access: http://mrw.so/5pQ5Lp
Image by Urmas Ojango, from Flickr-cc.
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