Single Intravenous Injection of CoQ10 Reduces Infarct Size in a Rat Model of Ischemia and Reperfusion Injury
Myocardial infarct, commonly known as a heart attack, occurs when blood flow decreases or
stops to a part of the heart, causing irreversible loss of cardimyocytes
accompanied by deterioration of contractile function and arrhythmias. Maintenance
of mitochondrial activity and antioxidant features of coenzyme Q10 (CoQ10)
could be an effective background for treatment of acute myocardial ischemia.
Dietary uptake of CoQ10 is limited to only a few percent. In
urgent cases, parenteral administration of CoQ10 could provide
fast increase of its plasma and myocardial levels. The aim of the study is to
investigate the effects of single intravenous (i.v.) pretreatment of
solubilized CoQ10 on its myocardial level and IR injury.
30 min prior to coronary artery occlusion rats received i.v. solubilized
CoQ10 (30 mg/kg) or saline (1 ml/kg). After 30 min of ischemia
and 120 min of reperfusion, infarct zone of left ventricle (LV) and quantity of
CoQ10 in LV were determined. Cardiac rhythm was monitored
through the whole experiment. The results indicated that at the beginning
of reperfusion, arrhythmias were recorded in 8 (from 9) in saline and 2 (from
9) in CoQ10-treated rats. Arrhythmias in CoQ10-treated
rats arose later (40 ± 8 sec) and had less duration (26 ± 14 sec); 14 ± 13 sec
and 52 ± 17 sec in saline treated rats respectively. At the end of reperfusion
CoQ10 treated rats revealed: 2 fold higher CoQ10 content
in LV (p < 0.01), limitation of infarct zone by 35% (p < 0.01). Higher
levels of CoQ10 were accompanied by less infarct size (r = ﹣0.77, p < 0.001).
In conclusion, single i.v. injection of CoQ10 effectively
increased its myocardial levels and protected heart against IR injury by
diminishing the size of the irreversibly damaged myocardium, decreasing
frequency and duration of arrhythmias. The infarct zone inversely correlated
with the quantity of CoQ10 in LV.
Article by Alexander
Ivanov, et al, from Russia.
Full access: http://mrw.so/4nhUWd
Image by Jack Teagle, from Flickr-cc
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