Nerve fibers are
very thin, thread-like transmission lines that carry signals between nerves and
receptors in the skin, muscles, and internal organs in human body. Their
official job is to conduct nerve impulses, which basically means that they are
responsible for delivering signals and sensations from the nerves to various
parts of the body. Commonly, people can suffer a variety of different health
consequences when the fibers connecting the nerves to transmission sites break
down or lose efficiency. According to some research, it has been known that the
presence of nerve fibers in human endometrium is controversial and still
remains unsettled.
However, some recent
immunocytochemical studies have shown that there was increased innervation in
the endometrium from women with endometriosis and some nerve fibers in the
normally cycling human endometrium. Due to this fact, in the current study, the
authors detected the presence of nerve fibers in normally cycling endometrium
of different menstrual cycle using NF and CD 56 immunostaining in basalis,
functionalis and myometrium.
A total of 16 cases
from normally cycling women were included representing menstrual, early
proliferative, early to late secretary phase. Neurofilament and CD 56 were used
as immunocytochemical markers for nerve fibers with cryosections. The results
showed that there were consistent presence of nerve fibers in myometrium and
basalis. Few small nerve fibers were identified in early proliferative
endometrium and more nerve fibers were present in lower-half functionalis from
mid-secretary phase. Late-secretary functionalis showed less nerve fibers in
the upper-half than the lower-half functionalis, implying growing nerve fibers
from lower functionalis to upper functionalis in late-secretary phase.
In conclusion,
Nerve fibers appeared to cyclically grow from basalis to lower functionalis and
then from lower functionalis to upper functionalis concomitantly with blood
vessels in normally cycling human endometrium. These cycling endometrial nerve
fibers consisted mostly of nonmyelinated small nerve fibers, which may transmit
pelvic pain in the normally cycling women.
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Image by pmarek98, from Flickr-cc.
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