Gout is the leading cause of microcrystalline arthritis worldwide
and the most common cause of arthritis in adult men. The prevalence of
cardiovascular disease, type II diabetes and metabolic syndrome is high among
gout patients; one of the current hypotheses that may explain this relationship
is based on oxidative stress; however, few studies have sought to investigate
this relationship. The aim of this study was to determine the oxidative status
of patients with gout attack.
We conducted a case-control study over a 4 months period at the
Rheumatology service of the Yaoundé Central Hospital. Cases were patients with
an acute gout attack and controls were healthy subjects matched for sex and
age. We evaluated uricemia, serum levels of Superoxide Dismutase (SOD),
Glutathione Peroxidase (GPx), Catalase and Malondialdehyde (MDA). Oxidative
stress was defined by an increase in MDA and/or a decrease in SOD, Catalase and
GPx. Statistical analysis was performed by the S.P.S.S. 21.0 software. The
Student’s T-test was used to compare means; the significance threshold was
0.05.
Sixty subjects were recruited of which 30 with an acute gout attack
and 30 healthy subjects. The mean ages of the cases and controls were
respectively 58 ± 8 years and 57.6 ± 8 years. Uricemia was statistically higher
in cases (81 ± 20 mg/L) compared to controls (47 ± 11 mg/L) (p < 0.001). MDA
levels were higher among cases (1.37 ± 0.46 mmol/L) compared to controls (1.14
± 0.39 mmol/L) (p < 0.05). There was no significant difference in serum
levels of catalase, SOD and GPx between cases and controls.
Patients with gout attack have an elevated serum level of
malondialdehyde but their oxidative status seems similar to that of normal
individuals.
Article by Vicky Ama Moor,et al,from Cameroon.
Full access: http://mrw.so/2ONKcl
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| Image by National Library of Medicine,from Flickr-cc. |
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