Gout, one of the most painful form of inflammatory arthritis, is characterized
by sudden, severe attacks of pain, redness and tenderness in joints, often the
joint at the base of the big toe. It’s reported that gout is one of the most
frequently referenced medical disorders in the history of mankind and its cases
have increased in recent years because of an aging population, the rise in
obesity, increasing numbers of people who also have other conditions such
as heart disease, kidney disease, and/or diabetes. And it’s the
result of too much uric acid in the blood, which is called hyperuricemia.
According to some literature, it has been proved that hyperuricemia is
associated to the development of high blood pressure, type II diabetes, chronic
kidney disease, cardiovascular and cerebrovascular events and it seems that
this relationship is based on oxidative stress, which is
essentially an imbalance between the production of free radicals and the
ability of the body to counteract or detoxify their harmful effects through
neutralization by antioxidants.
In this paper, to know about the relationship between these diseases
and hyperuricemia, the authors conducted a case-control study from the 4th
January to the 4th May 2016 at the Rheumatology service of the Yaoundé Central
Hospital and aimed to determine the oxidative status of patients with gout
attack. They first collected 60 samples and the average age of gout patients
was 58 ± 8 years old that of the controls was 57.6 ± 8 years old; then carried
out basic physical examination and collected blood samples; next they conducted
biochemical analysis and statistical analysis.
The findings indicated that people affected by gout had over 50 years old
(90%) and the most represented age group was 50 to 60 years old (53%); the
average uricemia of cases (81 ± 20 mg/L) was statistically higher than that of
the controls; the malondialdehyde (MDA) levels were higher among cases (1.37 ±
0.46 mmol/L) compared to controls (1.14 ± 0.39 mmol/L); and there was no
significant difference in serum levels of catalase, superoxide dismutase (SOD)
and glutathione
peroxidase (GPx) between cases and controls. SOD, GPx, MDA and catalase are markers
of oxidative stress.
In conclusion, patients with acute gout have an elevated serum level
of malondialdehyde, but their oxidative status seems similar to that of normal
individuals.
Article by Jan René Nkeck, et al, from
Yaoundé, Cameroon.
Read more @ http://mrw.so/1wBjfm
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| Image by Roxy Bentsen, from Flickr-cc. |
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