跳至主要内容

Circulating IgG antibody against FOXP3 may be a potential biomarker for lung cancer

Forkhead box P3 (FOXP3) has been found to be overexpressed by a range of cancer cells and correlated with prognosis of tumors. This finding raises the possibility that the development of anti-FOXP3 antibody test may be useful for clinical application. The present work was designed to test whether circulating autoantibody to FOXP3 was altered in lung cancer. 271 patients with non-small cell lung cancer (NSCLC) and 227 in control subjects matched in age, gender and smoking history were recruited. Circulating antiFOXP3 IgG antibody was tested using an inhouse enzymelinked immunosorbent assay.

Student’s t-test showed that the levels of IgG autoantibody to FOXP3 were significantly higher in patients with NSCLC than control subjects (t = 7.67, P < 0.0001). Receiver operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) was 0.70 (95% CI 0.65 - 0.75, SE ± 0.024), in which patients at stage 2 had the highest AUC of 0.75 (95%CI 0.67 - 0.81, SE ± 0.037), with a sensitivity of 31.4% against a specificity of 90.3%. Analysis of quality control samples gave an inter-assay deviation of 13.3% among 45 plates tested. Conclusions: Circulating IgG autoantibody to FOXP3 may be a potential biomarker for lung cancer. The conclusions is circulating IgG autoantibody to FOXP3 may be a potential biomarker for lung cancer.

Article by Weili Wang,et al,from China.

Full access: http://mrw.so/3AIBo6
Image by Lisa Marie Cannon,from Flickr-cc.

评论

发表评论

此博客中的热门博文

Electron Spin and Proton Spin in the Hydrogen and Hydrogen-Like Atomic Systems

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52202#.VIj7tMnQrzE Author(s) Stanisław Olszewski * Affiliation(s) Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland . ABSTRACT The mechanical angular momentum and magnetic moment of the electron and proton spin have been calculated semiclassically with the aid of the uncertainty principle for energy and time. The spin effects of both kinds of the elementary particles can be expressed in terms of similar formulae. The quantization of the spin motion has been done on the basis of the old quantum theory. It gives a quantum number n = 1/2 as the index of the spin state acceptable for both the electron and proton ...
发表评论
阅读全文

Remarks on the Complexity of Signed k-Domination on Graphs

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53574#.VMnXsCzQrzE Author(s)    Chuan-Min Lee 1 , Cheng-Chien Lo 1 , Rui-Xin Ye 2 , Xun Xu 2 , Xiao-Han Shi 2 , Jia-Ying Li 2 Affiliation(s) 1 Department of Computer and Communication Engineering, Ming Chuan University, The First American University in Asia, Taoyuan, Taiwan, Chinese Taipei . 2 Department of Electronic Information Engineering, Fuzhou University, Fuzhou, China . ABSTRACT This paper is motivated by the concept of the signed k-domination problem and dedicated to the complexity of the problem on graphs. For any fixed nonnegative integer k, we show that the signed k-domination problem is NP-complete for doubly chordal graphs. For strongly chordal graphs and distance-hereditary graphs, we show that the signed k-domination problem can be solved in polynomial time. We also show that the problem is linear-time solvable for trees, interval graphs, and chord...
发表评论
阅读全文

A Review of Technical Requirements for High Penetration of Wind Power Systems

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52361#.VJN8VcCAM4 Author(s)    Yuan-Kang Wu 1 , Tung-Ching Lee 2 , Ting-Yen Hsieh 2 , Wei-Min Lin 2 Affiliation(s) 1 Department of Electrical Engineering, National Chung-Cheng University, Chiayi, Taiwan . 2 Green Energy and Environment Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan . ABSTRACT Renewable portfolio targets have been established in many regions around the world. Regional targets such as 20% renewable energy by year 2020 are not uncommon. As the levels of wind power penetration increase, there are many power system impacts. This work investigated possible challenges and technic...
发表评论
阅读全文