跳至主要内容

Intensity Modulated Proton Therapy as a Boost Treatment after Prostate Seed Implant: A Treatment Planning Study

Read  full  paper  at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=54092#.VO12-CzQrzE

Author(s)
 
ABSTRACT
Purpose: Combination of Prostate Seed Implant (PSI) with External Beam Radiation Therapy (EBRT) remains as an attractive option for patients with intermediate or high-risk prostate cancer. One of the most widely used approaches is to use external beam radiation therapy (EBRT) to deliver boost doses after permanent prostate seed implant (PSI). In this study, the feasibility of using Intensity Modulated Proton Therapy (IMPT) as an alternative EBRT boost treatment for PSI patients was investigated in the presence of a large number of high Z metallic seeds. The dosimetry of IMPT boost plans was compared with that of conventional Intensity Modulated Radiation Therapy (IMRT) boost plans. Methods: Ten post prostate seed implants with seeds of I-125 were randomly selected for this study. Proton treatment plans were created with two lateral opposed proton beams in Eclipse treatment planning system. IMRT boost plans were generated with seven co-planner beams for comparison. Several plan evaluation parameters such as the planning target volume (PTV) dose homogeneity, dose conformity and dose to surrounding normal tissues were evaluated. Results: Compared to conventional IMRT boost plans, IMPT demonstrated better sparing of normal tissues while providing similar satisfactory PTV coverage. The high Z implanted seeds is not a problem for IMPT as boost treatment. Conclusions: PSI with an IMPT boost can be a valuable option for prostate cancer patient treatment. It delivers comparable or better radiation dose distribution in terms of normal tissue sparing compared to IMRT boost plan.
 
Cite this paper
Wu, J. , Wu, H. and Cheng, C. (2015) Intensity Modulated Proton Therapy as a Boost Treatment after Prostate Seed Implant: A Treatment Planning Study. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 4, 76-83. doi: 10.4236/ijmpcero.2015.41011.
 
References
[1]Jani, A.B., Hand, C.M., Lujan, A.E., Roeske, J.C., Zagaja, G.P., Vijayakumar, S. and Pelizzari, C.A. (2004) Biological Effective Dose for Comparison and Combination of External Beam and Low-Dose Rate Interstitial Brachytherapy Prostate Cancer Treatment Plans. Medical Dosimetry, 29, 42-48.
http://dx.doi.org/10.1016/j.meddos.2003.09.005
 
[2]Zaider, M., Zelefsky, M.J., Cohen, G.N., Chui, C.-S., Yorke, E.D., Ben-Porat, L. and Happersett, L. (2005) Methodology for Biologically-Based Treatment Planning for Combined Low-Dose-Rate (Permanent Implant) and High-Dose-Rate (Fractionated) Treatment of Prostate Cancer. International Journal of Radiation Oncology Biology Physics, 61, 702-713. http://dx.doi.org/10.1016/j.ijrobp.2004.06.251
 
[3]Zelefsky, M.J., Nedelka, M.A., Arican, Z.-L., Yamada, Y., Cohen, G.N., Shippy, A.M., Park, J.J. and Zaider, M. (2008) Combined Brachytherapy with External Beam Radiotherapy for Localized Prostate Cancer: Reduced Morbidity with an Intraoperative Brachytherapy Planning Technique and Supplemental Intensity-Modulated Radiation Therapy. Brachytherapy, 7, 1-6. http://dx.doi.org/10.1016/j.brachy.2007.12.002
 
[4]Zilli, T., Boudreau, C., Filion, E.J., Donath, D. and Taussky, D. (2011) Combined Intensity-Modulated Radiation Therapy vs. Three-Dimensional Highly Conformal Radiotherapy after 125I Prostate Permanent Seed Brachytherapy: A Comparative Treatment Planning Study. Brachytherapy, 10, 416-420. http://dx.doi.org/10.1016/j.brachy.2010.12.005
 
[5]Cao, M., Ko, S.-C., Slessinger, E.D., DesRosiers, C.M., Johnstone, P.A. and Das, I.J. (2011) A Simple Method for Dose Fusion from Multimodality Treatment of Prostate Cancer: Brachytherapy to External Beam Therapy. Brachytherapy, 10, 214-220. http://dx.doi.org/10.1016/j.brachy.2010.08.007
 
[6]Albert, M., Tempany, C.M., Schultz, D., Chen, M.-H., Cormack, R.A., Kumar, S., et al. (2003) Late Genitourinary and Gastrointestinal Toxicity after Magnetic Resonance Image-Guided Prostate Brachytherapy with or without Neoadjuvant External Beam Radiation Therapy. Cancer, 98, 949-954. http://dx.doi.org/10.1002/cncr.11595
 
[7]Sarosdy, M.F. (2004) Urinary and Rectal Complications of Contemporary Permanent Transperineal Brachytherapy for Prostate Carcinoma with or without External Beam Radiation Therapy. Cancer, 101, 754-760.
http://dx.doi.org/10.1002/cncr.20446
 
[8]Zeitlin, S.I., Sherman, J., Raboy, A., Lederman, G. and Albert, P. (1998) High Dose Combination Radiotherapy for the Treatment of Localized Prostate Cancer. The Journal of Urology, 160, 91-95; discussion 95-96.
http://dx.doi.org/10.1016/S0022-5347(01)63042-8
 
[9]Lomax, A.J., Boehringer, T., Coray, A., Egger, E., Goitein, G., Grossmann, M., et al. (2001) Intensity Modulated Proton Therapy: A Clinical Example. Medical Physics, 28, 317-324.
http://dx.doi.org/10.1118/1.1350587
 
[10]Polo, A., Salembier, C., Venselaar, J. and Hoskin, P. (2010) Review of Intraoperative Imaging and Planning Techniques in Permanent Seed Prostate Brachytherapy. Radiotherapy and Oncology, 94, 12-23.
http://dx.doi.org/10.1016/j.radonc.2009.12.012
 
[11]Bucci, J., Spadinger, I., Hilts, M., Sidhu, S., Smith, C., Keyes, M. and James Morris, W. (2002) Urethral and Periurethral Dosimetry in Prostate Brachytherapy: Is There a Convenient Surrogate? International Journal of Radiation Oncology*Biology*Physics, 54, 1235-1242.
http://dx.doi.org/10.1016/S0360-3016(02)03054-7
 
[12]Nakamura, J.L., Verhey, L.J., Smith, V., Petti, P.L., Lamborn, K.R., Larson, D.A., et al. (2001) Dose Conformity of Gamma Knife Radiosurgery and Risk Factors for Complications. International Journal of Radiation Oncology*Biology*Physics, 51, 1313-1319.
http://dx.doi.org/10.1016/S0360-3016(01)01757-6
 
[13]Paddick, I. (2000) A Simple Scoring Ratio to Index the Conformity of Radiosurgical Treatment Plans. Technical Note. Journal of Neurosurgery, 93, 219-222.
 
[14]Hall, E.J. and Wuu, C.S. (2003) Radiation-Induced Second Cancers: The Impact of 3D-CRT and IMRT. International Journal of Radiation Oncology*Biology*Physics, 56, 83-88.
http://dx.doi.org/10.1016/S0360-3016(03)00073-7
 
[15]Newhauser, W., Fontenot, J., Koch, N., Dong, L., Lee, A., Zheng, Y.S., et al. (2007) Monte Carlo Simulations of the Dosimetric Impact of Radiopaque Fiducial Markers for Proton Radiotherapy of the Prostate. Physics in Medicine and Biology, 52, 2937-2952. http://dx.doi.org/10.1088/0031-9155/52/11/001
 
[16]Newhauser, W.D., Koch, N.C., Fontenot, J.D., Rosenthal, S.J., Gombos, D.S., Fitzek, M.M. and Mohan, R. (2007) Dosimetric Impact of Tantalum Markers Used in the Treatment of Uveal Melanoma with Proton Beam Therapy. Physics in Medicine and Biology, 52, 3979-3790. http://dx.doi.org/10.1088/0031-9155/52/13/021
 
[17]Mendenhall, N.P., Malyapa, R.S., Su, Z., Yeung, D., Mendenhall, W.M. and Li, Z.F. (2011) Proton Therapy for Head and Neck Cancer: Rationale, Potential Indications, Practical Considerations, and Current Clinical Evidence. Acta Oncologica, 50, 763-771. http://dx.doi.org/10.3109/0284186X.2011.590147
 
[18]Yohannes, I., Kolditz, D., Langner, O. and Kalender, W.A. (2012) A Formulation of Tissue- and Water-Equivalent Materials Using the Stoichiometric Analysis Method for CT-Number Calibration in Radiotherapy Treatment Planning. Physics in Medicine and Biology, 57, 1173-1190. http://dx.doi.org/10.1088/0031-9155/57/5/1173
 
[19]Schaffner, B. and Pedroni, E. (1998) The Precision of Proton Range Calculations in Proton Radiotherapy Treatment Planning: Experimental Verification of the Relation between CT-HU and Proton Stopping Power. Physics in Medicine and Biology, 43, 1579-1592. http://dx.doi.org/10.1088/0031-9155/43/6/016
 
[20]Cheng, C.-W., Zhao, L., Wolanski, M., Zhao, Q.Y., James, J., Dikeman, K., et al. (2013) Comparison of Tissue Characterization Curves for Different CT Scanners: Implication in Proton Therapy Treatment Planning. Translational Cancer Research, 1, 236-246.                            eww150225lx
标签：

评论

发表评论

此博客中的热门博文

Electron Spin and Proton Spin in the Hydrogen and Hydrogen-Like Atomic Systems

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52202#.VIj7tMnQrzE Author(s) Stanisław Olszewski * Affiliation(s) Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland . ABSTRACT The mechanical angular momentum and magnetic moment of the electron and proton spin have been calculated semiclassically with the aid of the uncertainty principle for energy and time. The spin effects of both kinds of the elementary particles can be expressed in terms of similar formulae. The quantization of the spin motion has been done on the basis of the old quantum theory. It gives a quantum number n = 1/2 as the index of the spin state acceptable for both the electron and proton ...
发表评论
阅读全文

Incorporation of High-Altitude Balloon Experiment in High School Science Classrooms

High-altitude balloon is a balloon, filled usually with helium or hydrogen that ascends into an area called “near space” or stratosphere. The most common type of high-altitude balloons are weather balloons. Other purposes include use as a platform for experiments in the upper atmosphere. Modern balloons generally contain electronic equipment such as radio transmitters, cameras, or satellite navigation systems, such as GPS receivers. The mission of the High-Altitude Balloon Experiment (HABE) is to acquire supporting data, validate enabling technologies, and resolve critical acquisition, tracking, and pointing (ATP) and fire control issues in support of future space-based precision pointing experiments. The use of high-altitude balloons offers a relatively low-cost, low-vibration test platform, a recoverable and reusable payload, worldwide launch capability, and a 'near- space' emulation of the future space systems operational scenarios. More recently, several university...
1 条评论
阅读全文

Fermented Brown Sugar Residue Prolongs the Caenorhabditis elegans Lifespan via DAF-16

Fermented brown sugar residue (FBSR) is generated in the course of purifying biomass ethanol from the yeast fermentation products of brown sugar. It contains abundant nutrition and is used in various industrial applications including as fertilizer and feed. Meanwhile, brown sugar has attracted attention as a health food and is thought to prevent cardiovascular diseases, hypertension, and brain stem diseases. Furthermore, polyphenol, contained in brown sugar, reduces oxidative stress and inhibits glucose absorption. DAF-16 is a transcription factor regulated downstream of the insulin signaling pathway and is one of the main factors contributing to aging and lifespan in C. elegans . Therefore, to determine the precise roles of the DAF-16 transcription factor in stress tolerance and life span, it is necessary to elucidate the signaling pathways involved in DAF-16 activation. This study was designed to elucidate the molecular mechanisms controlling the physiological stress toleran...
发表评论
阅读全文