Immunizing Vulnerable Populations Like Rag Pickers, Garbage Collectors, Municipality Workers and Newspaper Hawkers against Rabies in Shimla Municipality, HP, India
Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53354#.VMBecyzQrzE
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53354#.VMBecyzQrzE
ABSTRACT
Background:
Rabies is a zoonotic disease and many vulnerable sections like rag
pickers and municipality workers neglect animal bites due to ignorance
of their potential deadly outcomes. Stray dogs abound in garbage pits
and this population is exposed to their attacks. It should be a mandate
for municipalities to help protect their sanitary workforce, especially
rag pickers, from deadly infectious diseases such as Rabies,
Hepatitis-B, HIV, Tetanus etc. Objectives: Objective of this study was
to study methods to provide pre-exposure Rabies vaccination for such
highly exposed populations by engaging them and understanding their
perception of this disease through a constant dialogue with them.
Methods: We started by engaging with the rag pickers to know how best to
entice them to get themselves immunized. We then attempted to search
literature for the most practical methods likely to succeed in reducing
risk of rabies deaths in this population. Results: WHO approved 3
injections of 0.1 ml tissue culture vaccine on days 0, 7 and 21 were
tried but were shown to result in many dropouts among rag pickers for
repeat injections. We then followed a method where 0.1 ml of rabies
vaccine was injected at 4 different anatomical sited in one setting.
This proved acceptable and relatively inexpensive. A small number of
subjects were studied by determination of neutralizing antibody by
RFFIT, which proved immunogenic having anamnestic response on boosters
given single IM or at 4 sites ID subsequently, implying that short
schedule rabies pre-exposure vaccination can be done in high risk groups
and may save lives if applied to the poorest that are highly exposed.
Cite this paper
References
Bharti,
O. (2015) Immunizing Vulnerable Populations Like Rag Pickers, Garbage
Collectors, Municipality Workers and Newspaper Hawkers against Rabies in
Shimla Municipality, HP, India. World Journal of Vaccines, 5, 19-24. doi: 10.4236/wjv.2015.51003.
| [1] | Rauf,
M.U.A., Saleem, M.D., Anwer, M.O., et al. (2013) HIV, Hepatitis B and
Hepatitis C in Garbage Scavengers of Karachi. Journal of Pakistan
Medical Association, 63, 798-802. http://www.jpma.org.pk/PdfDownload/4256.pdf |
| [2] | Khawplod,
P., Wilde, H., Benjavongkulchai, M., et al. (2007) Immunogenicity Study
of Abbreviated Rabies Preexposure Vaccination Schedules, International
Society of Travel Medicine, 1195-1982. Journal of Travel Medicine, 14,
173-176. http://onlinelibrary.wiley.com/doi/10.1111/j.1708-8305.2007.00120.x/pdf http://dx.doi.org/10.1111/j.1708-8305.2007.00120.x |
| [3] | Khawplod,
P., Wilde, H., Sriaroon, C., Chomchey, P., Kamolthum, T., Sitprija, V.,
et al. (2008) One or Three Intradermal Injections within One Week for
Rabies Pre-Exposure Immunization. Developments in Biologicals, 131, 393-
401. http://www.ncbi.nlm.nih.gov/pubmed/18634501 |
| [4] | Warrell,
M.J. (2012) Current Rabies Vaccines and Prophylaxis Schedules:
Preventing Rabies before and after Exposure. Travel Medicine and
Infectious Disease, 10, 1-15. http://www.travelmedicinejournal.com/article/S1477-8939(11)00130-X/abstract http://dx.doi.org/10.1016/j.tmaid.2011.12.005 |
| [5] | Bharti,
O.K., Damme, W., Decoster, K., Isaakidis, P., Appelmans, A.,
Ramachandran, V. and Phull, A. (2012) Breaking the Barriers to Access a
Low Cost Intra-Dermal Rabies Vaccine through Innovative “Pooling
Strategy”. World Journal of Vaccines, 2, 121-124. http://dx.doi.org/10.4236/wjv.2012.23016 |
| [6] | Garba
A., Umoh, J.U., et al. (2015) Rabies Virus Neutralizing Antibodies in
Unvaccinated Rabies Occupational Risk Groups in Niger State, Nigeria.
International Journal of Tropical Disease & Health, 6, 35-43. http://dx.doi.org/10.9734/IJTDH/2015/14461 |
| [7] | Ekanem,
E.E., Eyong, K.I., et al. (2013) Stray Dog Trade Fuelled by Dog Meat
Consumption as a Risk Factor for Rabies Infection in Calabar, Southern
Nigeria. African Health Sciences, 13, 1170-1173. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056491/ http://dx.doi.org/10.4314/ahs.v13i4.44 |
| [8] | Mshelbwala,
P.P., et al. (2013) Detection of Rabies Antigen in the Saliva and
Brains of Apparently Healthy Dogs Slaughtered for Human Consumption and
Its Public Health Implications in Abia State, Nigeria. ISRN Veterinary
Science, 2013, Article ID: 468043. http://www.hindawi.com/journals/isrn/2013/468043/ |
| [9] | Wertheim,
H.F.L., Nguyen, T.Q., Nguyen, K.A.T., de Jong, M.D., Taylor, W.R.J., et
al. (2009) Furious Rabies after an Atypical Exposure. PLoS Medicine, 6,
e1000044. http://dx.doi.org/10.1371/journal.pmed.1000044 |
| [10] | Atuman,
Y.J., Adawa, Y.A., Solomon, A., Mshelbwala, P.P. and Ogunkoya, A.B.
(2014) Potential Risks for Rabies Spill-Over from Apparently Healthy
Dogs to Wildlife in Bauchi State, Nigeria. Journal of Veterinary
Advances, 4, 493-498. http://dx.doi.org/10.5455/jva.20140418115203 |
| [11] | Mshelbwala,
P.P., Ogunkoya, A.B. and Maikai, B.V. (2013) Detection of Rabies
Antigen in the Saliva and Brains of Apparently Healthy Dogs Slaughtered
for Human Consumption and Its Public Health Implications in Abia State,
Nigeria. ISRN Veterinary Science, 2013, Article ID 468043, 5 p. http://dx.doi.org/10.1155/2013/468043. |
| [12] | Dhillon,
S., Sampath, K., Moore, C., Dosanjh, A. and Thiel, D. (2013) High-Dose
Intra-Dermal Hepatitis B Vaccine in a Liver Transplant Patient Who
Failed Prior Intramuscular Vaccination: A Brief Case Report. World
Journal of Vaccines, 3, 16-18. http://dx.doi.org/10.4236/wjv.2013.31003 |
| [13] | Chutivongse,
S., Wild, H., et al. (1991) One-Year Study of the 2-1-1 Intramuscular
Postexposure Rabies Vaccine Regimen in 100 Severely Exposed Thai
Patients Using Rabies Immune Globulin and Vero Cell Rabies Vaccine.
Vaccine, 9, 573-576. http://www.ncbi.nlm.nih.gov/pubmed/1771970 http://dx.doi.org/10.1016/0264-410X(91)90244-Z |
| [14] | Turner,
G.S., Aoki, F.Y., et al. (1976) Human Diploid Cell Strain Rabies
Vaccine. Rapid Prophylactic Immunization of Volunteers with Small Doses.
The Lancet, 307, 1379-1381. http://www.ncbi.nlm.nih.gov/pubmed/59017 http://dx.doi.org/10.1016/S0140-6736(76)93028-2 eww150122lx |
评论
发表评论