跳至主要内容

Effects of Post-Training Blockade of GABAB Receptor on Memory of Food Location and Expression of Synapsin I in the Hippocampus of Pigeons (Columba livia)

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52840#.VKoBycnQrzE

This study investigated effects of post-training treatment with phaclofen, GABAB receptor antagonist, on the memory of food location and on the expression of Synapsin I in the hippocampus of pigeons. Pigeons were trained in food location (7 sessions) and underwent post-training treatment with phaclofen (0.3 mg/kg, i.p.; PHAC), saline (SAL) or non-treated (NTR). Testing for memory persistence occurred 7 days after the last training session (PHACR, SALR and NTRR Groups). Pigeons treated with phaclofen had lower latency and higher correct choice values than saline and non-treated controls (p < 0.05). Analysis of hippocampus tissue indicated that Synapsin I-positive cell counts were higher in pigeons treated with phaclofen than in saline and non-treated controls (p < 0.05). Data indicated enhancement of consolidation and persistence of food location memory, and up-regulation of Synapsin I expression in the hippocampus of pigeons, which were related with post-training blockade of GABAB receptors.
Cite this paper
Canova, F. , Faria, R. and de Moraes Ferrari, E. (2014) Effects of Post-Training Blockade of GABAB Receptor on Memory of Food Location and Expression of Synapsin I in the Hippocampus of Pigeons (Columba livia). Journal of Behavioral and Brain Science, 4, 579-589. doi: 10.4236/jbbs.2014.412055.

[1] Eichenbaum, H., Otto, T. and Cohen, N.J. (1992) The Hippocampus—What Does It Do? Behavioral and Neural Biology, 7, 2-36.
http://dx.doi.org/10.1016/0163-1047(92)90724-I
[2] Mayer, U., Watanabe, S. and Bischof, H.J. (2013) Spatial Memory and the Avian Hippocampus: Research in Zebra Finches. Journal of Physiology, 107, 2-12.
[3] Kandel, E.R. (2001) The Molecular Biology of Memory Storage: A Dialogue between Genes and Synapses. Science, 294, 1030-1038.
http://dx.doi.org/10.1126/science.1067020
[4] Bowery, N.G. (2010) Historical Perspective and Emergence of the GABAB Receptor. Advances in Pharmacology, 58, 1-18.
http://dx.doi.org/10.1016/S1054-3589(10)58001-3
[5] Mott, D.D. and Lewis, D.V. (1994) The Pharmacology and Function of Central GABAB Receptors. International Review of Neurobiology, 36, 97-223.
http://dx.doi.org/10.1016/S0074-7742(08)60304-9
[6] Karten, H.J. and Hodos, W. (1967) A Stereotaxic Atlas of the Brain of the Pigeon (Columba livia). The Johns Hophins Press, Baltimore.
[7] Castellano, C., Cabib, S. and Puglisi-Allegra, S. (1996) Psychopharmacology of Memory Modulation: Evidence for Multiple Interaction among Neurotransmitters and Hormones. Behavioural Brain Research, 77, 1-21.
http://dx.doi.org/10.1016/0166-4328(96)00200-8
[8] Rapanelli, M., Frick, L.R. and Zanutto, B.S. (2009) Differential Gene Expression in the Rat Hippocampus during Learning of an Operant Conditioning Task. Neuroscience, 163, 1031-1038.
http://dx.doi.org/10.1016/j.neuroscience.2009.07.037
[9] Mohler, H., Fritschy, J.M., Crestani, F., Hensch, T. and Rudolph, U. (2004) Specific GABA(A) Circuits in Brain Development and Therapy. Biochemical Pharmacology, 68, 1685-1690.
http://dx.doi.org/10.1016/j.bcp.2004.07.025
[10] Mondadori, C., Buerki, H., Borkowski, J., Radeke, E., Ducret, T. and Glatt, A. (1992) CGS 5649 B, a New Compound, Reverses Age-Related Cognitive Dysfunctions in Rats. Behavioral and Neural Biology, 57, 149-156.
http://dx.doi.org/10.1016/0163-1047(92)90653-L
[11] Nakagawa, Y. and Takashima, T. (1997) The GABAB Receptor Antagonist CGP36742 Attenuates the Baclofen- and Scopolamine-Induced Deficit in Morris Water Maze Task in Rats. Brain Research, 766, 101-106.
http://dx.doi.org/10.1016/S0006-8993(97)00529-5
[12] Sunyer, B., Shim, K.S., An, G., Hoger, H. and Lubec, G. (2009) Hippocampal Levels of Phosphorylated Protein Kinase A (Phosphor-S96) Are Linked to Spatial Memory Enhancement by SGS742. Hippocampus, 19, 90-98.
http://dx.doi.org/10.1002/hipo.20484
[13] Froestl, W., Gallagher, M., Jenkins, H., Madrid, A., Melcher, T., Teichman, S., Mondadori, C.G. and Pearlman, R. (2004) SGS742: The First GABAB Receptor Antagonist in Clinical Trials. Biochemical Pharmacology, 68, 1479-1487.
http://dx.doi.org/10.1016/j.bcp.2004.07.030
[14] Gómez-Pinilla, F., So, V. and Kesslak, J.P. (2001) Spatial Learning Induces Neurotrophin Receptor and Synapsin I in the Hippocampus. Brain Research, 904, 13-19.
http://dx.doi.org/10.1016/S0006-8993(01)02394-0
[15] Güntürkün, O. (2012) The Convergent Evolution of Neural Substrates for Cognition. Psychological Research, 76, 212-219.
http://dx.doi.org/10.1007/s00426-011-0377-9
[16] Corradi, A., Zanardi, A., Giacomini, C., Onofri, F., Valtorta, F., Zoli, M. and Benfenati, F. (2008) Synapsin-I- and Synapsin-II-Null Mice Display an Increased Age-Dependent Cognitive Impairment. Journal of Cell Science, 121, 3042-3051.
http://dx.doi.org/10.1242/jcs.035063
[17] Jovanovic, J.N., Czernik, A.J., Fienberg, A.A., Greengard, P. and Sihra, T.S. (2000) Synapsins as Mediators of BDNF- Enhanced Neurotransmitter Release. Nature Neuroscience, 3, 323-329.
http://dx.doi.org/10.1038/73888
[18] Melloni Jr., R.H., Apostolides, P.J., Hamos, J.E. and De Gennaro, L.J. (1994) Dynamics of Synapsin I Gene Expression during the Establishment and Restoration of Functional Synapses in the Rat Hippocampus. Neuroscience, 58, 683-703.
http://dx.doi.org/10.1016/0306-4522(94)90448-0
[19] Amaral-Toma, M. and Ferrari, E.A.M. (2004) Effects of Hippocampal Lesions in a Food Location Task in Pigeons. Behavioral Brain Research, 148, 21-34.
[20] Kahn, M.C. and Bingman, V.P. (2009) Avian Hippocampal Role in Space and Content Memory. European Journal of Neuroscience, 30, 1900-1908.
http://dx.doi.org/10.1111/j.1460-9568.2009.06979.x
[21] Colombo, M. and Broadbent, N. (2000) Is the Avian Hippocampus a Functional Homologue of the Mammalian Hippocampus? Neuroscience & Biobehavioral Reviews, 24, 465-484.
http://dx.doi.org/10.1016/S0149-7634(00)00016-6
[22] Fremouw, T., Jackson-Smith, P. and Kesner, R.P. (1997) Impaired Place Learning and Unimpaired Cue Learning in Hippocampal-Lesioned Pigeons. Behavioral Neuroscience, 11, 963-975.
http://dx.doi.org/10.1037/0735-7044.111.5.955
[23] Watanabe, S. and Bischof, H.J. (2012) Spatial Cognition of Zebra Finches in a Morris-Maze Analogue Apparatus. International Journal of Comparative Psychology, 25, 276-284.
[24] Faria, R.S., Sartori, C.R., Canova, F. and Ferrari, E.A.M. (2013) Classical Aversive Conditioning Induces Increased Expression of Mature-BDNF in the Hippocampus and Amygdala of Pigeons. Neuroscience, 255, 122-133.
http://dx.doi.org/10.1016/j.neuroscience.2013.09.054
[25] Brito, I., Britto, L.R.G. and Ferrari, E.A.M. (2006) Classical Tone-Shock Conditioning Induces Zenk Expression in the Pigeon (Columba livia) Hippocampus. Behavioral Neuroscience, 120, 353-361.
http://dx.doi.org/10.1037/0735-7044.120.2.353
[26] Atoji, Y. and Wild, J.M. (2006) Anatomy of the Avian Hippocampal Formation. Reviews in the Neurosciences, 17, 3-15.
http://dx.doi.org/10.1515/REVNEURO.2006.17.1-2.3
[27] John, J.P., Sunyer, B., Hoger, H., Pollak, A. and Lubec, G. (2009) Hippocampal Synapsin Isoform Levels Are Linked to Spatial Memory Enhancement by SGS742. Hippocampus, 19, 731-778.
http://dx.doi.org/10.1002/hipo.20553
[28] Cullen, P.K., Dulka, B.N., Ortiz, S., Riccio, D.C. and Jasnow, A.M. (2014) GABA-Mediated Presynaptic Inhibition Is Required for Precision of Long-Term Memory. Learning & Memory, 21, 180-184.
http://dx.doi.org/10.1101/lm.032961.113
[29] Erichsen, J.T., Bingman, V.P. and Krebs, J.R. (1991) The Distribution of Neuropeptides in the Dorsomedial Telencephalon of the Pigeon (Columba livia): A Basis for Regional Subdivisions. Journal of Comparative Neurology, 314, 478-492.
http://dx.doi.org/10.1002/cne.903140306
[30] Herold, C., Bingman, V.P., Strockens, F., Letzner, S., Sauvage, M., Palomero-Gallagher, N., Zilles, K. and Güntürkün, O. (2014) Distribution of Neurotransmitter Receptors and Zinc in the Pigeon (Columba livia) Hippocampal Formation: A Basis for Further Comparison with the Mammalian Hippocampus. Journal of Comparative Neurology, 522, 2553-2575.
http://dx.doi.org/10.1002/cne.23549
[31] Kahn, M.C., Hough II, G.E., Eyck, G.R.T. and Bingman, V.P. (2003) Internal Connectivity of the Homing Pigeons (Columba livia) Hippocampal Formation: An Anterograde and Retrograde Tracer Study. Journal of Comparative Neurology, 459, 127-141.
http://dx.doi.org/10.1002/cne.10601
[32] Kushner, S.A., Elgersma, Y., Murphy, G.G., Jaarsma, D., van Woerden, G.M., Hojjati, M.R., Cui, Y., Le Boutillier, J.C., Marrone, D.F., Choi, E.S., De Zeeuw, C.I., Petit, T.L., Pozzo-Miller, L. and Silva, A.J. (2005) Modulation of Presynaptic Plasticity and Learning by the H-Ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway. The Journal of Neuroscience, 25, 9721-9734.
http://dx.doi.org/10.1523/JNEUROSCI.2836-05.2005
[33] Rosinha, M.U., Ferrari, E.A. and Toledo, C.A. (2009) Immunohistochemical Distribution of AMPA-Type Label in the Pigeon (C. livia) Hippocampus. Neuroscience, 159, 438-450.
http://dx.doi.org/10.1016/j.neuroscience.2009.01.010
[34] Hyland, N.P. and Cryan, J.F. (2010) A Gut Feeling about GABA: Focus on GABAB Receptors. Frontiers in Pharmacology, 1, 124.         eww150105lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文