跳至主要内容

Effects of Physical Activity Levels on Fatigue Perception in Patients with Parkinson’s Disease and Neurologically Healthy Individuals

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52548#.VJtpFcCAM4

Background: Recent researches involving fatigue and Parkinson’s disease (PD) sought to verify its incidence and the impacts of fatigue on quality life of patients with PD. Despite the importance of regular physical activity practice, there are only few studies that verified the influence of the levels of physical activity on fatigue in patients with PD. Objective: The aim of this study was to compare perception of fatigue between individuals with PD and neurologically healthy individuals (control group), considering the physical activity levels; and to verify the relation between physical activity levels and fatigue dimensions for individuals with PD and control group. Methods: Eighty individuals (40 patients with PD and 40 control individuals) participated in this study. Physical activity levels were evaluated through Modified Baecke Questionnaire for Older Adults. Multidimensional Fatigue Inventory (MFI) was used in order to evaluate fatigue dimensions (general, physical and mental fatigue, reduced motivation and activity). MANOVA two-way and Pearson linear correlation test were performed to analyze the data. Results: Patients with PD presented higher levels of fatigue, in all dimensions evaluated by MFI, comparing to control individuals. There was no association between physical activity levels and perception of fatigue for patients with PD and control individuals. Conclusion: Patients with PD showed increased perception of fatigue when compared to control individuals, due to PD characteristics. In addition, the perception of fatigue’s symptom was not influenced and had no relation by the level of physical activity.
Cite this paper
Santos, P. , Barbieri, F. , Orcioli-Silva, D. , Simieli, L. and Gobbi, L. (2014) Effects of Physical Activity Levels on Fatigue Perception in Patients with Parkinson’s Disease and Neurologically Healthy Individuals. Health, 6, 2927-2933. doi: 10.4236/health.2014.621331. 
 

[1] Friedman, J.H., Garber, C.E., Krupp, L.P., Lou, J.S.N., Marsh, L., Nail, L., Shulman, L. and Taylor, C.B. (2007) Fatigue in Parkinson’s Disease: A Review. Movement Disorders, 22, 297-308.
http://dx.doi.org/10.1002/mds.21240
[2] Herlofson, K. and Larsen, J.P. (2003) The Influence of Fatigue on Health-Related Quality of Life in Patients with Parkinson’s Disease. Acta Neurologica Scandinavica, 107, 1-6.
http://dx.doi.org/10.1034/j.1600-0404.2003.02033.x
[3] Friedman, J.H. and Friedman, H. (2001) Fatigue in Parkinson’s Disease. Movement Disorders, 16, 1120-1122.
http://dx.doi.org/10.1002/mds.1201
[4] Lou, J.S., Kearns, G., Oken, B., Sexton, G. and Nutt, J. (2001) Exacerbated Physical Fatigue and Mental Fatigue in Parkinson’s Disease. Movement Disorders, 16, 190-196.
http://dx.doi.org/10.1002/mds.1042
[5] Lou, J.S. (2009) Physical and Mental Fatigue in Parkinson’s Disease: Epidemiology, Pathophysiology and Treatment. Drugs Aging, 26, 195-208.
http://dx.doi.org/10.2165/00002512-200926030-00002
[6] Barone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T.P., Bottachi, E., Cannas, A., Ceravolo, R., Cicarelli, G., Ganglio, R.M., Lemolo, F., Manfredi, M., Meco, G., Nicoletti, A., Pederzoli, M., Petrone, A., Pisani, A., Pontieri, F.E., Quatrale, R., Remat, S., Scala, R., Volpe, G., Zappulla, S., Bentivoglio, A.R., Stocchi, F., Trianni, G. and Dotto, P.D. (2009) The PRIAMO Study: A Multicenter Assessment of Nonmotor Symptoms and Their Impact on Quality of Life in Parkinson’s Disease. Movement Disorders, 24, 1619-1641.
http://dx.doi.org/10.1002/mds.22643
[7] Havlikova, E., Rosenberger, J., Nagyova, I., Middel, B., Dubayova, T., Gdovinova, Z., Van Dijk, J.P. and Groothoff, J.W. (2008) Clinical and Psychosocial Factors Associated with Fatigue in Patients with Parkinson’s Disease. Parkinsonism & Related Disorders, 14, 187-192.
http://dx.doi.org/10.1016/j.parkreldis.2007.07.017
[8] Chaudhuri, A., Condon, B.R., Gow, J.W., Brennan, D. and Hadley, D.M. (2003) Proton Magnetic Resonance Spectroscopy of Basal Ganglia in Chronic Fatigue Syndrome. NeuroReport, 14, 225-228.
http://dx.doi.org/10.1097/00001756-200302100-00013
[9] Chaudhuri, A. and Behan, P.O. (2000) Fatigue and Basal Ganglia. Journal of the Neurological Sciences, 179, 34-42.
http://dx.doi.org/10.1016/S0022-510X(00)00411-1
[10] Pavese, N., Metta, V., Bose, S., Chaudhuri, K.R. and Brooks, D.J. (2010) Fatigue in Parkinson’s Disease Is Linked to Striatal and Limbic Serotonergic Dysfunction. Brain, 133, 3434-3443.
http://dx.doi.org/10.1093/brain/awq268
[11] Bryant, M.S., Rintala, D.H., Hou, J.G., Rivas, S.P., Fernandez, A.L., Lai, E.C. and Protas, E.J. (2012) The Relation of Falls to Fatigue, Depression and Daytime Sleepiness in Parkinson’s Disease. European Neurology, 67, 326-330.
http://dx.doi.org/10.1159/000335877
[12] Miwa, H. and Miwa, T. (2011) Fatigue in Patients with Parkinson’s Disease: Impact on Quality of Life. Internal Medicine, 50, 1553-1558.
http://dx.doi.org/10.2169/internalmedicine.50.4954
[13] Friedman, J.H. and Friedman, H. (1993) Fatigue in Parkinson’s Disease. Neurology, 43, 2016-2018.
http://dx.doi.org/10.1212/WNL.43.10.2016
[14] Lau, Y.S., Patki, G., Das-Panja, K., Le, W.D. and Ahmad, S.O. (2011) Neuroprotective Effects and Mechanisms of Exercise in a Chronic Mouse Model of Parkinson’s Disease with Moderate Neurodegeneration. European Journal of Neuroscience, 33, 1264-1274.
http://dx.doi.org/10.1111/j.1460-9568.2011.07626.x
[15] Tajiri, N., Yasuhara, T., Shingo, T., Kondo, A., Yuan, W., Kadota, T., Wang, F., Baba, T., Tayra, J., Morimoto, T., Jing, M., Kikuchi, Y., Kuramoto, S., Agari, T., Miyoshi, Y., Fujino, H., Obata, F., Takeda, I., Furuta, T. and Date, I. (2010) Exercise Exerts Neuroprotective Effects on Parkinson’s Disease Model of Rats. Brain Research, 1310, 200-207.
http://dx.doi.org/10.1016/j.brainres.2009.10.075
[16] Salmon, P. (2001) Effects of Physical Exercise on Anxiety, Depression, and Sensitivity to Stress: A Unifying Theory. Clinical Psychology Review, 21, 33-61.
http://dx.doi.org/10.1016/S0272-7358(99)00032-X
[17] Wilson, W.M. and Marsden, C.A. (1996) In Vivo Measurement of Extracellular Serotonin in the Ventral Hippocampus during Treadmill Running. Behavioural Pharmacology, 7, 101-104.
http://dx.doi.org/10.1097/00008877-199601000-00011
[18] Hoff, J.I., Van Hilten, J.J., Middelkoop, H.A.M. and Roos, R.A.C. (1997) Fatigue in Parkinson’s Disease Is Not Associated with Reduced Physical Activity. Parkinsonism Related Disorders, 3, 51-54.
[19] Elbers, R., Van Wegen, E.E., Rochester, L., Hetherington, V., Nieuwboer, A., Willems, A.M., Jones, D. and Kwakkel, G. (2009) Is Impact of Fatigue an Independent Factor Associated with Physical Activity in Patients with Idiopathic Parkinson’s Disease? Movement Disorders, 24, 1512-1518.
http://dx.doi.org/10.1002/mds.22664
[20] Hughes, A.J., Daniel, S.E., Kilford, L. and Lees, A.J. (1992) Accuracy of Clinical Diagnosis of Idiopathic Parkinson’s Disease: A Clinico-Pathological Study of 100 Cases. Journal of Neurology, Neurosurgery Psychiatry, 55, 181-184.
http://dx.doi.org/10.1136/jnnp.55.3.181
[21] Hoehn, M.M. and Yahr, M.D. (1967) Parkinsonism: Onset, Progression and Mortality. Neurology, 17, 573-581.
http://dx.doi.org/10.1212/WNL.17.5.427
[22] Schenkman, M.L., Clark, K., Xie, T., Kuchibhatla, M., Shinberg, M. and Ray, L. (2001) Spinal Movement and Performance of Standing Reach Task in Participants with and without Parkinson’s Disease. Physical Therapy, 81, 1400- 1411.
[23] Fahn, S., Elton, R. and Members of the UPDRS Development Committee (1987) The Unified Parkinson’s Disease Rating Scale. In: Fahn, S., Marsden, C.D., Calne, D.B. and Goldstein, M., Eds., Recent Developments in Parkinson’s Disease, Vol. 2, McMellam Health Care Information, Florham Park, 153-163.
[24] Brucki, S.M.D., Nitrini, R., Caramelli, P., Bertolucci, P.H.F. and Okamoto, I.H. (2003) Sugestoes para o uso do mini-exame do estado mental no Brasil. Arquivos de Neuro-Psiquiatria, 61, 777-781.
http://dx.doi.org/10.1590/S0004-282X2003000500014
[25] Voorrips, L.E., Ravelli, A.C., Dongelmans, P.C., Deurenberg, P. and Van Staveren, W.A. (1991) A Physical Activity Questionnaire for the Elderly. Medicine Science in Sports Exercise, 23, 974-979.
http://dx.doi.org/10.1249/00005768-199108000-00015
[26] Bink, B., Bonjer, F.H. and Van Der Sluys, H. (1966) Assessment of the Energy Expenditure by Indirect Time and Motion Study. In: Edang, K. and Andersen, K.L., Eds., Physical Activity in Health and Disease, Proceedings of the Bertoslos Symposium, Oslo University, Oslo, 207-214.
[27] Nascimento, C.M.C., Gobbi, S., Hirayama, M.S. and Brazao, M.C. (2008) Nível de atividade física e as principais barreiras percebidas por idosos de Rio Claro. Revista da Educacao Física/UEM, 19, 109-118.
[28] Smets, E.M.A., Garssen, B., Bonke, B. and De Haes, J.C. (1995) The Multidimensional Fatigue Inventory (MFI) Psychometric Qualities of an Instrument to Assess Fatigue. Journal of Psychiatric Research, 39, 315-325.
[29] Friedman, J.H., Alves, G., Hagell, P., Marinus, J., Marsh, L., Martinez-Martin, P., Goetz, C.G., Poewe, W., Rascol, O., Sampaio, C., Stebbins, G. and Schrag, A. (2010) Fatigue Rating Scales Critique and Recommendations by the Movement Disorders Society Task Force on Rating Scales for Parkinson Disease. Movement Disorders, 25, 805-822.
http://dx.doi.org/10.1002/mds.22989
[30] Rochester, L., Hetherington, V., Jones, D., Nieuwboer, A., Willems, A.M., Kwakkel, G. and Van Wegen, E. (2004) Attending to the Task: Interference Effects of Functional Tasks on Walking in Parkinson’s Disease and the Roles of Cognition, Depression, Fatigue and Balance. Archives of Physical Medicine and Rehabilitation, 85, 1578-1585.
http://dx.doi.org/10.1016/j.apmr.2004.01.025
[31] Hirsch, M.A. and Farley, B.G. (2009) Exercise and Neuroplasticity in Persons Living with Parkinson’s Disease. European Journal of Physical and Rehabilitation Medicine, 45, 215-229.                   eww141225lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文