HDL-Mediated Protection of Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic Swine
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Author(s)
It is known that high-cholesterol diet impairs
coronary vasodilatation in animal models of athe-rosclerosis
irrespective of overt pathology. We evaluated the specific role of LDL
and HDL on adenosine-elicited coronary vasodilatation after short time
(10 weeks) high-cholesterol diet in pigs. Nineteen pigs on standard (C),
atherogenic (HF) and alternate standard or atherogenic diet every other
week (IHF) underwent left coronary angiography and flow (CFR)
measurement during intracoronary adenosine injection. Total cholesterol,
HDL, LDL, Apo lipoprotein A-1, IL-6, TNF-α and ICAM-1 were measured and
histology of coronary samples was performed. IHF and HF show comparable
intimal thickening of lesions, similar cholesterol (598.4 ± 198.2 and
633.2 ± 83.5 mg/dL) and LDL (502.6 ± 193.7 and 576.1 ± 83.2), while HDL
is double in IHF group (88.3 ± 6.4 vs 46.4 ± 18.7 p < 0.0001).
Vasodilation is reduced in HF (CFR = 1.6 ± 0.2, p < 0.001) as
compared to C (2.6 ± 0.4), whilst it is preserved in IHF (2.7 ± 0.4).
CFR and HDL values of all hypercholesterolemia cases are positively
correlated (r = 0.88, p < 0.001). No relation with cytokines/cell
adhesion markers is present. These findings suggest for the first time
that elevation of plasma HDL level counteracts LDL related vasodilation
impairment during coronary atherogenesis in swine.
KEYWORDS
Cite this paper
Vozzi, F. , Pelosi, G. , Puntoni, M. , Viglione, F. ,
Rocchiccioli, S. , Kusmic, C. , Bernini, F. , Marraccini, P. ,
Trivella, M. and Parodi, O. (2014) HDL-Mediated Protection of
Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic
Swine. Open Journal of Molecular and Integrative Physiology, 4, 49-61. doi: 10.4236/ojmip.2014.44006.
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