跳至主要内容

Extraordinary Potential of High Technologies Applications: A Literature Review and a Model of Assessment of Head and Neck Squamous Cell Carcinoma (HNSCC) Prognosis

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51154#.VFbluGfHRK0

Author(s) 
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cause of cancer mortality in the world and the 5th most commonly occurring cancer (Siegel, R. 2014). In the last few decades a growing interest for the emerging data from both tumor biology and multimodality treatment in HNSCC has been developed. A huge number of new markers need to be managed with bio-informatics systems to elaborate and correlate clinical and molecular data. Data mining algorithms are a promising medical application. We used this technology to correlate blood samples with clinical outcome in 120 patients treated with chemoradiation for locally advanced HNSCC. Our results did not find a significant correlation because of the sample exiguity but they show the potential of this tool.
Cite this paper
Camuto, C. and Denaro, N. (2014) Extraordinary Potential of High Technologies Applications: A Literature Review and a Model of Assessment of Head and Neck Squamous Cell Carcinoma (HNSCC) Prognosis. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 3, 235-240. doi: 10.4236/ijmpcero.2014.34030. 
 

[1] Banville, D.L. (2009) Mining Chemical and Biological Information from the Drug Literature. Current Opinion in Drug Discovery & Development, 12, 376-387.
[2] Zhu, F., Patumcharoenpol, P., Zhang, C., Yang, Y., Chan, J., Meechai, A., Vongsangnak, W. and Shen, B. (2013) Biomedical Text Mining and Its Applications in Cancer Research. Journal of Biomedical Informatics, 46, 200-211.
http://dx.doi.org/10.1016/j.jbi.2012.10.007
[3] Siegel, R., Naishadham, D. and Jemal, A. (2013) Cancer statistics, 2013. CA: A Cancer Journal for Clinicians, 63, 11-30.
http://dx.doi.org/10.3322/caac.21166
[4] Denaro, N., Russi, E.G., Adamo, V. and Merlano, M.C. (2014) State-of-the-Art and Emerging Treatment Options in the Management of Head and Neck Cancer: News from 2013. Oncology, 86, 212-229.
[5] Ang, K.K., Harris, J., Wheeler, R., Weber, R., Rosenthal, D.I., Nguyen-Tan, P.F., Westra, W.H., Chung, C.H., Jordan, R.C., Lu, C., Kim, H., Axelrod, R., Silverman, C.C., Redmond, K.P. and Gillison, M.L. (2010) Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer. New England Journal of Medicine, 363, 24-35.
http://dx.doi.org/10.1056/NEJMoa0912217
[6] Wu, J., Ho, C., Laskin, J., Gavin, D., Mak, P., Duncan, K., French, J., McGahan, C., Reid, S., Chia, S. and Cheung, H. (2013) The Development of a Standardized Software Platform to Support Provincial Population-Based Cancer Outcomes Units for Multiple Tumour Sites: OaSIS—Outcomes and Surveillance Integration System. Studies in Health Technology and Informatics, 183, 98-103.
[7] Naqa, I.E, Deasy, J.O., Mu, Y., Huang, E., Hope, A.J., Lindsay, P.E., Apte, A., Alaly, J. and Bradley, J.D. (2010) Datamining Approaches for Modeling Tumor Control Probability. Acta Oncologica, 49, 1363-73.
http://dx.doi.org/10.3109/02841861003649224
[8] Spencer, S.J., Bonnin, D.A., Deasy, J.O., Bradley, J.D. and El Naqa, I. (2009) Bioinformatics Methods for Learning Radiation-Induced Lung Inflammation from Heterogeneous Retrospective and Prospective Data. Journal of Biomedicine and Biotechnology, 2009, 1-14.
http://dx.doi.org/10.1155/2009/892863                     eww141103lx
标签：

评论

发表评论

此博客中的热门博文

A Comparison of Methods Used to Determine the Oleic/Linoleic Acid Ratio in Cultivated Peanut (Arachis hypogaea L.)

Cultivated peanut ( Arachis hypogaea L.) is an important oil and food crop. It is also a cheap source of protein, a good source of essential vitamins and minerals, and a component of many food products. The fatty acid composition of peanuts has become increasingly important with the realization that oleic acid content significantly affects the development of rancidity. And oil content of peanuts significantly affects flavor and shelf-life. Early generation screening of breeding lines for high oleic acid content greatly increases the efficiency of developing new peanut varieties. The objective of this study was to compare the accuracy of methods used to classify individual peanut seed as high oleic or not high oleic. Three hundred and seventy-four (374) seeds, spanning twenty-three (23) genotypes varying in oil composition (i.e. high oleic (H) or normal/not high oleic (NH) inclusive of all four peanut market-types (runner, Spanish, Valencia and Virginia), were individually tested ...
发表评论
阅读全文

Location Optimization of a Coal Power Plant to Balance Costs against Plant’s Emission Exposure

Fuel and its delivery cost comprise the biggest expense in coal power plant operations. Delivery of electricity from generation to consumers requires investment in power lines and transmission grids. Placing a coal power plant or multiple power plants near dense population centers can lower transmission costs. If a coalmine is nearby, transportation costs can also be reduced. However, emissions from coal plants play a key role in worsening health crises in many countries. And coal upon combustion produces CO 2 , SO 2 , NO x , CO, Metallic and Particle Matter (PM10 & PM2.5). The presence of these chemical compounds in the atmosphere in close vicinity to humans, livestock, and agriculture carries detrimental health consequences. The goal of the research was to develop a methodology to minimize the public’s exposure to harmful emissions from coal power plants while maintaining minimal operational costs related to electric distribution losses and coal logistics. The objective was...
发表评论
阅读全文

Evaluation of the Safety and Efficacy of Continuous Use of a Home-Use High-Frequency Facial Treatment Appliance

At present, many home-use beauty devices are available in the market. In particular, many products developed for facial treatment use light, e.g., a flash lamp or a light-emitting diode (LED). In this study, the safety of 4 weeks’ continuous use of NEWA TM , a high-frequency facial treatment appliance, every alternate day at home was verified, and its efficacy was evaluated in Japanese individuals with healthy skin aged 30 years or older who complained of sagging of the facial skin.  Transepidermal water loss (TEWL), melanin levels, erythema levels, sebum secretion levels, skin color changes and wrinkle improvement in the facial skin were measured before the appliance began to be used (study baseline), at 2 and 4 weeks after it had begun to be used, and at 2 weeks after completion of the 4-week treatment period (6 weeks from the study baseline). In addition, data obtained by subjective evaluation by the subjects themselves on a visual analog scale (VAS) were also analyzed. Fur...
发表评论
阅读全文