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The Oxytocin Receptor Gene (OXTR) and Gazing Behavior during Social Interaction: An Observational Study in Young Adults

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Background: In the present study, the relation between a polymorphic marker within the OXTR gene (rs53576) and gazing behavior during two separate social interaction tasks was examined. Gazing behavior was considered to be an integral part of belonging regulation processes. Methods: We conducted an observational interaction study (N = 116; 58 dyads) in a naturalistic setting. Participants were seated face to face with hidden cameras positioned behind them. Each couple was instructed to have two short conversations about daily topics (nightlife in the city and movies), separated by a distraction task. We studied the role of the OXTR gene in relation to gaze duration (total duration and mean duration per event) at the interaction partner, both for the total interaction and for the first and second halves of the interaction, separately. Results: Analyses showed a significant relationship between the OXTR genetic variant and mean gaze duration at the interaction partner. Individuals carrying an A-allele showed increased gaze duration. This genetic association was particularly present during the first half of the conversation. In the second interaction task, we confirmed the findings that A-allele carriers showed longer mean gaze duration. No associations were found for total gaze duration. Conclusions: The OXTR A-allele was associated with longer mean gaze duration at an unknown interaction partner, especially during the first halves of the interaction times. This might illustrate that A-carriers, compared to GG-homozygous individuals, need slightly more time to read the micro socio-emotional facial cues of a new interaction partner or need more time for social reconciliation processes. This could be indicative of a genetic liability for being less vulnerable to pick up new micro social cues.
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Verhagen, M. , Engels, R. and Roekel, E. (2014) The Oxytocin Receptor Gene (OXTR) and Gazing Behavior during Social Interaction: An Observational Study in Young Adults. Open Journal of Depression, 3, 136-146. doi: 10.4236/ojd.2014.34017. 
 

[1] Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2010). Acute Effects of Intranasal Oxytocin on Subjective and Behavioral Responses to Social Rejection. Experimental and Clinical Psychopharmacology, 18, 316-321. http://dx.doi.org/10.1037/a0019719
[2] Andari, E., Duhamel, J. R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010). Promoting Social Behavior with Oxytocin in High-Functioning Autism Spectrum Disorders. Proceedings of the National Academy of Sciences of the United States of America, 107, 4389-4394.
http://dx.doi.org/10.1073/pnas.0910249107
[3] Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2014). A Sociability Gene? Meta-Analysis of Oxytocin Receptor Genotype Effects in Humans. Psychiatric Genetics, 24, 45-51.
http://dx.doi.org/10.1097/YPG.0b013e3283643684
[4] Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., & Ochsner, K. N. (2010). Oxytocin Selectively Improves Empathic Accuracy. Psychological Science, 21, 1426-1428.
http://dx.doi.org/10.1177/0956797610383439
[5] Baumeister, R. F., & Leary, M. R. (1995). The Need to Belong: Desire for Interpersonal Attachments as a Fundamental Human Motivation. Psychological Bulletin, 117, 497-529.
http://dx.doi.org/10.1037/0033-2909.117.3.497
[6] Baumeister, R. F., Brewer, L. E., Tice, D. M., & Twenge, J. M. (2007). Thwarting the Need to Belong: Understanding the Interpersonal and Inner Effects of Social Exclusion. Social and Personality Psychology Compass, 1, 506-520. http://dx.doi.org/10.1111/j.1751-9004.2007.00020.x
[7] Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck Depression Inventory (2nd ed.). San Antonio, TX: The Psychological Corporation.
[8] Blackhart, G. C., Baumeister, R. F., & Twenge, J. M. (2006). Rejection’s Impact on Self-Defeating, Prosocial, Antisocial, and Self-Regulatory Behaviors. In K. D. Vohs & E. J. Finkel, (Eds.), Self and Relationships: Connecting Intrapersonal and Interpersonal Processes (pp. 237-253). New York: Guilford Press.
[9] Cacioppo, J. T., Norris, C. J., Decety, J., Monteleone, G., & Nusbaum, H. (2009). In the Eye of the Beholder: Individual Differences in Perceived Social Isolation Predict Regional Brain Activation to Social Stimuli. Journal of Cognitive Neuroscience, 21, 83-92.
http://dx.doi.org/10.1162/jocn.2009.21007
[10] Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A. et al. (2009). Oxytocin Receptor Polymorphisms and Adult Attachment Style in Patients with Depression. Psychoneuroendocrinology, 34, 1506-1514. http://dx.doi.org/10.1016/j.psyneuen.2009.05.006
[11] Cyranowski, J. M., Hofkens, T. L., Frank, E., Seltman, H., Cai, H. M., & Amico, J. A. (2008). Evidence of Dysregulated Peripheral Oxytocin Release among Depressed Women. Psychosomatic Medicine, 70, 967-975. http://dx.doi.org/10.1097/PSY.0b013e318188ade4
[12] Dal Monte, O., Noble, P. L., Costa, V. D., & Averbeck, B. B. (2014). Oxytocin Enhances Attention to the Eye Region in Rhesus Monkeys. Frontiers in Neuroscience, 8, 41.
http://dx.doi.org/10.3389/fnins.2014.00041
[13] De Vente, W., Majdandzic, M., Voncken, M. J., Beidel, D. C., & Bogels, S. M. (2014). The Spai-18, a Brief Version of the Social Phobia and Anxiety Inventory: Reliability and Validity in Clinically Referred and Non-Referred Samples. Journal of Anxiety Disorders, 28, 140-147.
http://dx.doi.org/10.1016/j.janxdis.2013.05.003
[14] Does van der, A. J. W. (2002). BDI-II-NL Handleiding: De Nederlandse Versie Van de Beck Depression Inventory. (2nd ed.). Lisse: Harcourt Test Publishers.
[15] Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007). Oxytocin Improves “Mind-Reading” in Humans. Biological Psychiatry, 61, 731-733.
http://dx.doi.org/10.1016/j.biopsych.2006.07.015
[16] Gamer, M., Zurowski, B., & Büchel, C. (2010). Different Amygdala Subregions Mediate Valence-Related and Attentional Effects of Oxytocin in Humans. Proceedings of the National Academy of Sciences of the United States of America, 107, 9400-9405.
http://dx.doi.org/10.1073/pnas.1000985107
[17] Gardner, W. L., Pickett, C. L., Jefferis, V., & Knowles, M. (2005). On the Outside Looking In: Loneliness and Social Monitoring. Personality and Social Psychology Bulletin, 31, 1549-1560.
http://dx.doi.org/10.1177/0146167205277208
[18] Georgescu, A. L., Kuzmanovic, B., Schilbach, L., Tepest, R., Kulbida, R., Bente, G., & Vogeley, K. (2013). Neural Correlates of “Social Gaze” Processing in High-Functioning Autism under Systematic Variation of Gaze Duration. Neuroimage: Clinical, 3, 340-351.
http://dx.doi.org/10.1016/j.nicl.2013.08.014
[19] Gere, J., & MacDonald, G. (2010). An Update of the Empirical Case for the Need to Belong. The Journal of Individual Psychology, 66, 93-115.
[20] Gimpl, G., & Fahrenholz, F. (2001). The Oxytocin Receptor System: Structure, Function, and Regulation. Physiology Review, 81, 629-683.
[21] Goldberg, L. R. (1992). The Development of Markers for the Big-Five Factor Structure. Psychological Assessment, 4, 26-42. http://dx.doi.org/10.1037/1040-3590.4.1.26
[22] Gottesman, I., & Gould, T. D. (2003). The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions. American Journal of Psychiatry, 160, 636-645.
http://dx.doi.org/10.1176/appi.ajp.160.4.636
[23] Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001). Oxytocin and Autistic Disorder: Alterations in Peptide Forms. Biological Psychiatry, 50, 609-613.
http://dx.doi.org/10.1016/S0006-3223(01)01139-8
[24] Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008). Oxytocin Increases Gaze to the Eye Region of Human Faces. Biological Psychiatry, 63, 3-5. http://dx.doi.org/10.1016/j.biopsych.2007.06.026
[25] Hawkley, L. C., Preacher, K. J., & Cacioppo, J. T. (2007). Multilevel Modeling of Social Interactions and Mood in Lonely and Socially Connected Individuals: The Macarthur Social Neuroscience Studies. In A. D. Ong, & Van Dulmen, M. (Eds.), Oxford Handbook of Methods in Positive Psychology (pp. 559-575). New York: Oxford University Press.
[26] Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000). The Distributed Human Neural System for Face Perception. Trends in Cognitive Sciences, 4, 223-233.
http://dx.doi.org/10.1016/S1364-6613(00)01482-0
[27] Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L. et al. (2007). Oxytocin Increases Retention of Social Cognition in Autism. Biological Psychiatry, 61, 498-503.
http://dx.doi.org/10.1016/j.biopsych.2006.05.030
[28] Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S. et al. (2010). Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans. Journal of Neuroscience, 30, 4999-5007.
http://dx.doi.org/10.1523/JNEUROSCI.5538-09.2010
[29] Insel, T. R. (1997). A Neurobiological Basis of Social Attachment. American Journal of Psychiatry, 154, 726-735.
[30] Insel, T. R. (2010). The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior. Neuron, 65, 768-779.
http://dx.doi.org/10.1016/j.neuron.2010.03.005
[31] Insel, T. R., & Young, L. J. (2001). The Neurobiology of Attachment. Nature Reviews Neuroscience, 2, 129-136. http://dx.doi.org/10.1038/35053579
[32] Ishak, W. W., Kahloon, M., & Fakhry, H. (2011). Oxytocin Role in Enhancing Well-Being: A Literature Review. Journal of Affective Disorders, 130, 1-9. http://dx.doi.org/10.1016/j.jad.2010.06.001
[33] Itier, R. J., & Batty, M. (2009). Neural Bases of Eye and Gaze Processing: The Core of Social Cognition. Neuroscience and Biobehavioral Reviews, 33, 843-863.
http://dx.doi.org/10.1016/j.neubiorev.2009.02.004
[34] Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook Jr., E. H. (2007). Association of the Oxytocin Receptor Gene (OXTR) in Caucasian Children and Adolescents with Autism. Neuroscience Letters, 417, 6-9. http://dx.doi.org/10.1016/j.neulet.2007.02.001
[35] Kogan, A., Saslow, L. R., Impett, E. A., Oveis, C., Keltner, D., & Saturn, S. R. (2011). Thin-Slicing Study of the Oxytocin Receptor (OXTR) Gene and the Evaluation and Expression of the Prosocial Disposition. Proceedings of the National Academy of Sciences of the United States of America, 108, 19189-19192.
http://dx.doi.org/10.1073/pnas.1112658108
[36] Kuntsche, E., & Jordan, M. D. (2006). Adolescent Alcohol and Cannabis Use in Relation to Peer and School Factors: Results of Multilevel Analyses. Drug and Alcohol Dependence, 84, 167-174.
http://dx.doi.org/10.1016/j.drugalcdep.2006.01.014
[37] Leary, M. R. (1990). Responses to Social Exclusion: Social Anxiety, Jealousy, Loneliness, Depression, and Low Self-Esteem. Journal of Social and Clinical Psychology, 9, 221-229.
http://dx.doi.org/10.1521/jscp.1990.9.2.221
[38] Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W. et al. (2009). Associations between the Oxytocin Receptor Gene (OXTR) and Affect, Loneliness and Intelligence in Normal Subjects. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33, 860-866.
http://dx.doi.org/10.1016/j.pnpbp.2009.04.004
[39] Macdonald, K., & Macdonald, T. M. (2010). The Peptide That Binds: A Systematic Review of Oxytocin and Its Prosocial Effects in Humans. Harvard Review of Psychiatry, 18, 1-21.
http://dx.doi.org/10.3109/10673220903523615
[40] Masten, C. L., Eisenberger, N. I., Borofsky, L. A., Pfeifer, J. H., McNealy, K., Mazziotta, J. C., & Dapretto, M. (2009). Neural Correlates of Social Exclusion during Adolescence: Understanding the Distress of Peer Rejection. Social Cognitive and Affective Neuroscience, 4, 143-157.
http://dx.doi.org/10.1093/scan/nsp007
[41] Meyer-Lindenberg, A. (2008). Impact of Prosocial Neuropeptides on Human Brain Function. Progress in Brain Research, 170, 463-470. http://dx.doi.org/10.1016/S0079-6123(08)00436-6
[42] Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxytocin and Vasopressin in the Human Brain: Social Neuropeptides for Translational Medicine. Nature Reviews Neuroscience, 12, 524-538. http://dx.doi.org/10.1038/nrn3044
[43] Muthén, L. K., & Muthén, B. O. (1998-2007). Mplus User’s Guide (5th ed.). Los Angeles, CA: Muthén & Muthén.
[44] Park, J., Willmott, M., Vetuz, G., Toye, C., Kirley, A., Hawi, Z. et al. (2010). Evidence That Genetic Variation in the Oxytocin Receptor (OXTR) Gene Influences Social Cognition in ADHD. Progress in Neuro-Psychopharmacological and Biological Psychiatry, 34, 697-702.
http://dx.doi.org/10.1016/j.pnpbp.2010.03.029
[45] Pickett, C. L., Gardner, W. L., & Knowles, M. (2004). Getting a Cue: The Need to Belong and Enhanced Sensitivity to Social Cues. Personality and Social Psychology Bulletin, 30, 1095-1107.
http://dx.doi.org/10.1177/0146167203262085
[46] Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin Receptor Genetic Variation Relates to Empathy and Stress Reactivity in Humans. Proceedings of the National Academy of Sciences of the United States of America, 106, 21437-21441.
http://dx.doi.org/10.1073/pnas.0909579106
[47] Roelofs, J., van Breukelen, G., de Graaf, L. E., Beck, A. T., Arntz, A., & Huibers, M. J. H. (2013). Norms for the Beck Depression Inventory (BDI-II) in a Large Dutch Community Sample. Journal of Psychopathology and Behavioral Assessment, 35, 93-98.
http://dx.doi.org/10.1007/s10862-012-9309-2
[48] Russell, D., Peplau, L. A., & Cutrona, C. E. (1980). The Revised UCLA Loneliness Scale: Concurrent and Discriminant Validity Evidence. Journal of Personality and Social Psychology, 39, 472-480.
http://dx.doi.org/10.1037/0022-3514.39.3.472
[49] Scantamburlo, G., Hansenne, M., Fuchs, S., Pitchot, W., Marechal, P., Pequeux, C. et al. (2007). Plasma Oxytocin Levels and Anxiety in Patients with Major Depression. Psychoneuroendocrinology, 32, 407-410. http://dx.doi.org/10.1016/j.psyneuen.2007.01.009
[50] Tansey, K. E., Brookes, K. J., Hill, M. J., Cochrane, L. E., Gill, M., Skuse, D. et al. (2010). Oxytocin Receptor (OXTR) Does Not Play a Major Role in the Aetiology of Autism: Genetic and Molecular Studies. Neuroscience Letters, 474, 163-167. http://dx.doi.org/10.1016/j.neulet.2010.03.035
[51] Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S. et al. (2010). A Common Allele in the Oxytocin Receptor Gene (OXTR) Impacts Prosocial Temperament and Human Hypothalamic-Limbic Structure and Function. Proceedings of the National Academy of Sciences of the United States of America, 107, 13936-13941. http://dx.doi.org/10.1073/pnas.1003296107
[52] van Roekel, E., Verhagen, M., Engels, R. C., Goossens, L., & Scholte, R. H. (2013). Oxytocin Receptor Gene (OXTR) in Relation to Loneliness in Adolescence: Interactions with Sex, Parental Support, and DRD2 and 5-HTTLPR Genotypes. Psychiatric Genetics, 23, 204-213.
http://dx.doi.org/10.1097/YPG.0b013e328363f631
[53] van Roekel, E., Verhagen, M., Scholte, R. H., Kleinjan, M., Goossens, L., & Engels, R. C. (2013). The Oxytocin Receptor Gene (OXTR) in Relation to State Levels of Loneliness in Adolescence: Evidence for Micro-Level Gene-Environment Interactions. PLoS ONE, 8, e77689.
http://dx.doi.org/10.1371/journal.pone.0077689
[54] van Straaten, I., Holland, R. W., Finkenauer, C., Hollenstein, T., & Engels, R. C. (2010). Gazing Behavior During Mixed-Sex Interactions: Sex and Attractiveness Effects. Archives of Sexual Behavior, 39, 1055-1062. http://dx.doi.org/10.1007/s10508-009-9482-x
[55] Vermulst, A. A., & Gerris, J. R. M. (2005). QBF: Quick Big Five Persoonlijkheidstest Handleiding (Quick Big Five Personality Test Manual). Leeuwarden: LDC.
[56] Wermter, A. K., Kamp-Becker, I., Hesse, P., Schulte-Korne, G., Strauch, K., & Remschmidt, H. (2010). Evidence for the Involvement of Genetic Variation in the Oxytocin Receptor Gene (OXTR) in the Etiology of Autistic Disorders on High-Functioning Level. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B, 629-639.
[57] Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Shuang, M. et al. (2005). Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population. Biological Psychiatry, 58, 74-77.
http://dx.doi.org/10.1016/j.biopsych.2005.03.013             eww141008lx
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