跳至主要内容

The Action of Chronic Nicotine on the Effects of Ethanol on Anxiety, Locomotion and Metabolism and the Feeding and Drinking Behaviors of Rats

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50993#.VFHRPlfHRK0

The objective of these experiments was to study the effects of ethanol on the anxiety level, activity, metabolic rate, and feeding and drinking behaviors of rats that were chronically treated with nicotine. The chronic intake of nicotine changed the effects of the acute administration of ethanol. Thus, the nicotine-dependent rats demonstrated a significantly decreased anxiolytic-like effect in response to ethanol than did the control rats. This decrease may lead to a decrease in the sensitivity of animals to the positive reinforcing effects of ethanol and an increase in their consumption to achieve the desired effect. The negative action of ethanol on the metabolism, motor activity and drinking behavior of rats that chronically consumed nicotine was increased. Chronic nicotine intake can be assumed to lead to cross-tolerance of the effects of ethanol. On the contrary, the sensitivity to the action of ethanol increased.
Cite this paper
Bashkatova, V. , Sudakov, S. , Nazarova, G. and Alexeeva, E. (2014) The Action of Chronic Nicotine on the Effects of Ethanol on Anxiety, Locomotion and Metabolism and the Feeding and Drinking Behaviors of Rats. Pharmacology & Pharmacy, 5, 1077-1084. doi: 10.4236/pp.2014.511117. 
 

[1] Miller, N.S. and Gold, M.S. (1998) Comorbid Cigarette and Alcohol Addiction: Epidemiology and Treatment. Journal of Addictive Diseases, 17, 55-66.
http://dx.doi.org/10.1300/J069v17n01_06
[2] Alburges, M.E., Hoonakker, A.J. and Hanson, G.R. (2007) Nicotinic and Dopamine D2 Receptors Mediate Nicotine-Induced Changes in Ventral Tegmental Area Neurotensin System. European Journal of Pharmacology, 573, 124-132.
http://dx.doi.org/10.1016/j.ejphar.2007.06.063
[3] Novak, G., Seeman, P. and Le Foll, B. (2010) Exposure to Nicotine Produces an Increase in Dopamine D2 (High) Receptors: A Possible Mechanism for Dopamine Hypersensitivity. International Journal of Neuroscience, 120, 691-697. http://dx.doi.org/10.3109/00207454.2010.513462
[4] Schier, C.J., Dilly, G.A. and Gonzales, R.A. (2013) Intravenous Ethanol Increases Extracellular Dopamine in the Medial Prefrontal Cortex of the Long-Evans rat. Alcoholism: Clinical and Experimental Research, 37, 740-747. http://dx.doi.org/10.1111/acer.12042
[5] Collins, A.C., Burch, J.B., de Fiebre, C.M. and Marks, M.J. (1988) Tolerance to and Cross Tolerance between Ethanol and Nicotine. Pharmacology, Biochemistry and Behavior, 29, 365-373.
http://dx.doi.org/10.1016/0091-3057(88)90170-0
[6] Collins, A.C., Wilkins, L.H., Slobe, B.S., Cao, J.Z. and Bullock, A.E. (1996) Long-Term Ethanol and Nicotine Treatment Elicit Tolerance to Ethanol. Alcoholism: Clinical and Experimental Research, 6, 990-999.
http://dx.doi.org/10.1111/j.1530-0277.1996.tb01936.x
[7] López-Moreno, J.A., Scherma, M., Rodríguez de Fonseca, F., González-Cuevas, G., Fratta, W. and Navarro, M. (2008) Changed Accumbal Responsiveness to Alcohol in Rats Pre-Treated with Nicotine or the Cannabinoid Receptor Agonist WIN 55,212-2. Neuroscience Letters, 433, 1-5.
http://dx.doi.org/10.1016/j.neulet.2007.11.074
[8] Söderpalm, B., Ericson, M., Olausson, P., Blomqvist, O. and Engel, J.A. (2000) Nicotinic Mechanisms Involved in the Dopamine Activating and Reinforcing Properties of Ethanol. Behavioural Brain Research, 113, 85-96.
http://dx.doi.org/10.1016/S0166-4328(00)00203-5
[9] Lallemand, F., Ward, R.J. and De Witte, P. (2009) The Influence of Chronic Nicotine Administration on Behavioral and Neurochemical Parameters of Male and Female Rats after Repeated Binge Drinking Exposure. Alcohol Alcoholism, 44, 535-546.
http://dx.doi.org/10.1093/alcalc/agp047
[10] Proctor, W.R., Dobelis, P., Moritz, A.T. and Wu, P.H. (2011) Chronic Nicotine Treatment Differentially Modifies acute Nicotine and Alcoholactions on GABA(A) and Glutamate Receptors in Hippocampal Brain Slices. British Journal of Pharmacology, 162, 1351-1363.
http://dx.doi.org/10.1111/j.1476-5381.2010.01141.x
[11] Burch, J.B., de Fiebre, C.M., Marks, M.J. and Collins, A.C. (1988) Chronic Ethanol or Nicotine Treatment Results in Partial Cross-Tolerance between These Agents. Psychopharmacology, 95, 452-458.
http://dx.doi.org/10.1007/BF00172954
[12] Johnson, D.H., Blomqvist, O., Engel, J.A. and Söderpalm, B. (1995) Subchronic Intermittent Nicotine Treatment Enhances Ethanol-Induced Locomotor Stimulation and Dopamine Turnover in Mice. Behavioural Pharmacology, 6, 203-207.
http://dx.doi.org/10.1097/00008877-199503000-00013
[13] Clark, A., Lindgren, S., Brooks, S.P., Watson, W.P. and Little, H.J. (2001) Chronic Infusion of Nicotine Can Increase Operant Self-Administration of Alcohol. Neuropharmacology, 41, 108-117.
http://dx.doi.org/10.1016/S0028-3908(01)00037-5
[14] Leow, Y.H. and Maibach, H.I. (1998) Cigarette Smoking, Cutaneous Vasculature, and Tissue Oxygen. Clinics in Dermatology, 16, 579-584.
http://dx.doi.org/10.1016/S0738-081X(98)00042-X
[15] Levin, E.D., Morgan, M.M., Galvez, C. and Ellison, G.D. (1987) Chronic Nicotine and Withdrawal Effects on Body Weight and Food and Water Consumption in Female Rats. Physiology & Behavior, 39, 441-444.
http://dx.doi.org/10.1016/0031-9384(87)90370-2
[16] Taylor, B.E., Brundage, C.M. and McLane, L.H. (2013) Chronic Nicotine and Ethanol Exposure Both Disrupt Central Ventilatory Responses to Hypoxia in Bullfrog Tadpoles. Respiratory Physiology & Neurobiology, 187, 234-243.
http://dx.doi.org/10.1016/j.resp.2013.04.004
[17] Essig, C.F. (1968) Increased Water Consumption Following Forced Drinking of Alcohol in Rats. Psychopharmacologia, 12, 333-337.
http://dx.doi.org/10.1007/BF00401411
[18] Wager-Srdar, S.A., Levine, A.S., Morley, J.E., Hoidal, J.R. and Niewoehner, D.E. (1984) Effects of Cigarette Smoke and Nicotine on Feeding and Energy. Physiology & Behavior, 32, 389-395.
http://dx.doi.org/10.1016/0031-9384(84)90252-X
[19] Pellow, S., Chopin, P., File, S.E. and Briley, M. (1985) Validation of Open: Closed Arm Entries in an Elevated Plus-Maze as a Measure of Anxiety in the Rat. Journal of Neuroscience Methods, 14, 149-167.
http://dx.doi.org/10.1016/0165-0270(85)90031-7
[20] Biala, G. and Budzynska, B. (2006) Effects of Acute and Chronic Nicotine on Elevated Plus Maze in Mice: Involvement of Calcium Channel. Life Sciences, 79, 81-88.
http://dx.doi.org/10.1016/j.lfs.2005.12.043
[21] Tizabi, Y., Hauser, S.R., Tyler, K.Y., Getachew, B., Madani, R., Sharma, Y. and Manaye, K.F. (2010) Effects of Nicotine on Depressive-Like Behavior and Hippocampal Volume of Female WKY Rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34, 62-69.
http://dx.doi.org/10.1016/j.pnpbp.2009.09.024
[22] Turner, J.R., Castellano, L.M. and Blendy, J.A. (2011) Parallel Anxiolytic-Like Effects and Upregulation of Neuronal Nicotinic Acetylcholine Receptors Following Chronic Nicotine and Varenicline. Nicotine & Tobacco Research, 13, 41-46.
http://dx.doi.org/10.1093/ntr/ntq206
[23] Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., Moretti, M., Pedrazzi, P., Pucci, L. and Zoli, M. (2009) Structural and Functional Diversity of Native Brain Neuronal Nicotinic Receptors. Biochemical Pharmacology, 78, 703-711.
http://dx.doi.org/10.1016/j.bcp.2009.05.024
[24] Sajja, R.K. and Rahman, S. (2012) Neuronal Nicotinic Receptor Ligands Modulate Chronic Nicotine-Induced Ethanol Consumption in C57BL/6J Mice. Pharmacology Biochemistry and Behavior, 102, 36-43.
http://dx.doi.org/10.1016/j.pbb.2012.03.017
[25] Picciotto, M.R., Brunzell, D.H. and Caldarone, B.J. (2002) Effect of Nicotine and Nicotinic Receptors on Anxiety and Depression. Neuroreport, 13, 1097-1106.
http://dx.doi.org/10.1097/00001756-200207020-00006
[26] Salas, R., Main, A., Gangitano, D.A., Zimmerman, G., Ben-Ari, S., Soreq, H. and De Biasi, M. (2008) Nicotine Relieves Anxiogenic-Like Behavior in Mice that Overexpress the Read-Through Variant of Acetylcholinesterase but Not in Wild-Type Mice. Molecular Pharmacology, 74, 1641-1648.
http://dx.doi.org/10.1124/mol.108.048454
[27] Gulick, D. and Gould, T.J. (2008) Interactive Effects of Ethanol and Nicotine on Learning in C57BL/6J Mice Depend on both Dose and Duration of Treatment. Psychopharmacology, 196, 483-495.
http://dx.doi.org/10.1007/s00213-007-0982-x              eww141030lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文