跳至主要内容

Information Dynamics of Whole Genome Adaptation

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50325#.VDXvAFfHRK0\

The human genome is a complex, dynamic information system that encodes principles of life and living systems. These principles are incorporated in the structure of human genome sequence variation and are foundational for the continuity of life and human survival. Using first principles of thermodynamics and statistical physics, we have developed analogous “genodynamic tools” for population genomic studies. Characterizing genomic information through the lens of physics has allowed us to develop energy measures for modeling genome-environment interactions. In developing biophysical parameters for genome-environment homeostasis, we found that stable genomic free energy trades off low genomic energy (genomic conservation and increased order) and high genomic entropy (genomic variation) with an environmental potential that drives the variation. In our approach, we assert that common variants are dynamic sites in the genome of a population and that the stability of whole genome adaptation is reflected in the frequencies of maintained diversity in common variants for the population in its environment. In this paper, we address the relativity of whole genome adaptation towards homeostasis. By this we mean that adaptive forces are directly reflected in the frequency distribution of alleles and/or haplotypes of the population relative to its environment, with adaptive forces driving the genome towards homeostasis. The use of genomic energy units as a biophysical metric in DNA sequence variation analyses provides new insights into the foundations of population biology and diversity. Using our biophysical tools, population differences directly reflect the adaptive influences of the environment on populations.
Cite this paper
Hercules, W. , Lindesay, J. , Mason, T. and Dunston, G. (2014) Information Dynamics of Whole Genome Adaptation. Natural Science, 6, 1228-1231. doi: 10.4236/ns.2014.615110. 
 

[1] Eid, N.A., Hussein, A.A., Elzein, A.M., Mohamed, H.S., Rockett, K.A., Kwiatkowski, D.P. and Ibrahim, M.E. (2010) Candidate Malaria Susceptibility/Protective SNPs in Hospital and Population-Based Studies: The Effect of Sub-Structuring. Malaria Journal, 9, 119.
http://www.malariajournal.com/content/9/1/119
http://dx.doi.org/10.1186/1475-2875-9-119
[2] Kwiatkowski, D.P. (2005) How Malaria Has Affected the Human Genome and What Human Genetics Can Teach Us about Malaria. The American Journal of Human Genetics, 77, 171-190.
http://dx.doi.org/10.1086/432519
[3] Modiano, D., Petrarca, V., Sirima, B.S., Nebie, I., Diallo, D., Esposito, F. and Coluzzi, M. (1996) Different Response to Plasmodium falciparum Malaria in West African Sympatric Ethnic Groups. Proceedings of the National Academy of Sciences of the USA, 93, 13206-13211.
http://dx.doi.org/10.1073/pnas.93.23.13206
[4] Rihet, P., Traore, Y., Abel, L., Aucan, C., Leroux, T.T. and Fumoux, F. (1998) Malaria in Humans: Plasmodium falciparum Blood Infection Levels Are Linked to Chromosome 5q31-q33. The American Journal of Human Genetics, 63, 498-505.
http://dx.doi.org/10.1086/301967
[5] Driss, A., Hibbert, J.M., Wilson, N.O., Iqbal, S.A., Adamkiewicz, T.V. and Stiles, J.K. (2011) Genetic Polymorphisms Linked to Susceptibility to Malaria. Malaria Journal, 10, 271.
http://www.malariajournal.com/content/10/1/271
http://dx.doi.org/10.1186/1475-2875-10-271                  eww141009lx
 
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文