跳至主要内容

Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50622#.VEcjLFfHRK0

Introduction: Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare and extremely aggressive malignant entity. However, prognosis seems to be improved with the use of multimodality approach treatment. Cases: We report the cases of 50- and 51-year-old women, presenting with vaginal bleeding and mass. The two patients underwent radical surgery. Histological examination revealed RMS of uterine cervix. Treatment was effective in the first case but despite the chemotherapy, the second patient died two months later. Discussion and Conclusions: The prognosis of the cervical embryonal RMS depends on clinical and histological features. The current treatment protocols are based on trials done on pediatric patients. Studies on embryonal RMS treatment and outcomes are limited in women over forty years. In patients with unfavorable prognosis characteristics, the multimodality approach including surgery, adjuvant chemo and radiotherapy can be effective. Otherwise, surgery alone can effectively be proposed.
Cite this paper
Abdeljalil, K. , Asma, B. , Kouira, M. , Faten, H. , Sawssen, M. , Samir, H. , Mohamed, B. , Habib, E. and Hedi, K. (2014) Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review. Open Journal of Obstetrics and Gynecology, 4, 868-873. doi: 10.4236/ojog.2014.414122. 

[1] Young, J.L. and Miller, R.W. (1975) Incidence of Malignant Tumors in US Children. Journal of Pediatrics, 86, 254- 258. http://dx.doi.org/10.1016/S0022-3476(75)80484-7
[2] Maurer, H.M. (1981) The Intergroup Rhabdomyosarcoma Study: Update, Nov. 1978. National Cancer Institute Monograph, 56, 61-68.
[3] Gordon, A.N. and Montag, T.W. (1990) Sarcoma Botryoides of the Cervix: Excision Followed by Adjuvant Chemotherapy for Preservation of Reproductive Function. Gynecologic Oncology, 36, 119-124.
http://dx.doi.org/10.1016/0090-8258(90)90121-Z
[4] Miyamoto, T., Shiozawa, T., Nakamura, T., et al. (2004) Sarcoma Botryoides of the Uterine Cervix in a 46-Year-Old Woman: Case Report and Literature Review. International Journal of Gynecological Pathology, 23, 78-82. http://dx.doi.org/10.1097/01.pgp.0000101147.41312.54
[5] Brand, E.B., Nieberg, J.S. and Hacker, R.K. (1987) Rhabdomyosarcoma of the Uterine Cervix. Sarcoma Botryoides. Cancer, 60, 552-560.
http://dx.doi.org/10.1002/1097-0142(19871001)60:7<1552::AID-CNCR2820600724>3.0.CO;2-W
[6] Vlahos, N.P.M. and Veridiano, R. (1999) Cervical Sarcoma Botryoides. A Case Report. The Journal of Reproductive Medicine, 44, 306-308.
[7] Ober, W.B. (1971) Sarcoma Botryoides of the Cervix Uteri: A Case Report in a 75-Year-Old Woman. Mount Sinai Journal of Medicine, 38, 363-374.
[8] Sanders, M.A., Gordinier, M., Talwalkar, S.S., et al. (2008) Embryonal Rhabdomyosarcoma of the Uterine Cervix in a 41-Year-Old Woman Treated with Radical Hysterectomy and Adjuvant Chemotherapy. Gynecologic Oncology, 111, 561-563. http://dx.doi.org/10.1016/j.ygyno.2008.07.016
[9] Crist, W.M., Anderson, J.R., Meza, J.L., et al. (2001) Intergroup Rhabdomyosarcoma Study-IV: Results for Patients with Nonmetastatic Disease. Journal of Clinical Oncology, 19, 3091-3102.
[10] Dehner, L.P., Jarzembowski, J.A. and Hill, D.A. (2012) Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Report of 14 Cases and a Discussion of Its Unusual Clinicopathological Associations. Modern Pathology, 25, 602-614. http://dx.doi.org/10.1038/modpathol.2011.185
[11] Smrkolj, S., Rakar, S., Mali?, S., et al. (2011) Advanced Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Case Report. European Journal of Gynaecological Oncology, 32, 203-205.
[12] Sultan, I., Qaddoumi, I., Yaser, S., et al. (2009) Comparing Adult and Pediatric Rhabdomyosarcoma in the Surveillance, Epidemiology and End Results Program, 1973 to 2005: An Analysis of 2600 Patients. Journal of Clinical Oncology, 27, 3391-3397. http://dx.doi.org/10.1200/JCO.2008.19.7483
[13] Baiocchi, G., Faloppa, C.C., Osório, C.A., et al. (2011) Embryonal Rhabdomyosarcoma of the Uterine Cervix in a 47-Year-Old Woman. Journal of Obstetrics and Gynaecology Research, 37, 940-946. http://dx.doi.org/10.1111/j.1447-0756.2010.01449.x
[14] Anyiam, D.C.D., Ukah, C.O., Onyiaorah, I.V., et al. (2010) Sarcoma Botyroides of the Cervix in a HIV Positive 45-Year-Old Woman: A Case Report. Nigerian Journal of Clinical Practice, 13, 341-343.
[15] Hilgers, R.D., Malkasian, G.D. and Soule, E.H. (1970) Embryonal Rhabdomyosarcoma (Botryoid Type) of the Vagina: A Clinicopathologic Review. American Journal of Obstetrics and Gynecology, 107, 484-502.
[16] Daya, D.A. and Scully, R.E. (1988) Sarcoma Botryoides of the Uterine Cervix in Young Women: A Clinicopathological Study of 13 Cases. Gynecologic Oncology, 29, 290-304.
http://dx.doi.org/10.1016/0090-8258(88)90228-4
[17] Hays, D.M., Shimada, H., Raney, R.B., et al. (1988) Clinical Staging and Treatment Results in Rhabdomyosarcoma of the Female Genital Tract among Children and Adolescents. Cancer, 9, 1893-1903. http://dx.doi.org/10.1002/1097-0142(19880501)61:9<1893::AID-CNCR2820610929>3.0.CO;2-9
[18] Adams, B.N., Brandt, J.S., Loukeris, K., et al. (2011) Embryonal Rhabdomyosarcoma of the Cervix and Appendiceal Carcinoid Tumor. Obstetrics & Gynecology, 117, 482-484.
http://dx.doi.org/10.1097/AOG.0b013e3182051dd0
[19] Khosla, D., Gupta, R., Srinivasan, R., et al. (2012) Sarcomas of Uterine Cervix: Clinicopathological Features, Treatment and Outcome. International Journal of Gynecological Cancer, 22, 1026-1030. http://dx.doi.org/10.1097/IGC.0b013e31825a97f6
[20] Wieneer, E., Wharam, M., Vietti, T.J., et al. (1995) The Third Intergroup RMS Study. Journal of Clinical Oncology, 13, 610-630.        eww141022lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文