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Nimotuzumab in Treatment of Infiltrating Squamous Cell Carcinoma of Tongue

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http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53684#.VM80rSzQrzE

Author(s)  
Alex A. Prasad*

Affiliation(s)
Chennai Cancer Care Hospital, Chennai, India.

ABSTRACT
A 50-year male patient presented to outpatient department with a mass on tongue associated with pain. A plain computerised tomography scan done on 17/01/13 revealed mild growth on lateral border of tongue with an enlarged jugulo-digastric lymph node measuring 1.8 × 1 cm. Excision of tongue was done and sent for histopathological examination which revealed infiltrating squamous cell carcinoma. The patient was treated with 2 cycles of Induction chemotherapy with cisplatin and paclitaxel administered in q3w schedule. Induction chemotherapy was followed by concurrent chemoradiotherapy with 6 cycles of nimotuzumab 200 mg and cisplatin 20 mg given weekly along with 60 gy/30 fractions of radiation using IMRT. Latest CT scan done on 20/01/2014 revealed no evidence of disease (NED).

KEYWORDS
Nimotuzumab, Epidermal Growth Factor Receptor (EGFR), Transforming Growth Factor α (TGFα)

Cite this paper
Prasad, A. (2015) Nimotuzumab in Treatment of Infiltrating Squamous Cell Carcinoma of Tongue. Journal of Cancer Therapy, 6, 141-145. doi: 10.4236/jct.2015.62015.

References
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[3]Douglas, Q., et al. (1921) Treatment of Carcinoma of the Tongue. Annals of Surgery, 73, 716-723. http://dx.doi.org/10.1097/00000658-192106000-00005
 
[4]Globocan (2015) Fact Sheets by Population—Globocan—IARC.
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[5]Iype, E.M., Pandey, M., Mathew, A., Thomas, G., Sebastian, P. and Nair, M.K. (2001) Squamous Cell Carcinoma of the Tongue among Young Indian Adults. Neoplasia, 3, 273-277.
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[6]Ciardiello, F. and Tortora, G. (2008) EGFR Antagonists in Cancer Treatment. The New England Journal of Medicine, 358, 1160-1174. http://dx.doi.org/10.1056/NEJMra0707704
 
[7]Akashi, Y., Okamoto, I., Iwasa, T., et al. (2008) Enhancement of the Antitumor Activity of Ionising Radiation by Nimotuzumab, a Humanised Monoclonal Antibody to the Epidermal Growth Factor Receptor, in Non-Small Cell Lung Cancer Cell Lines of Differing Epidermal Growth Factor Receptor Status. British Journal of Cancer, 98, 749-755. http://dx.doi.org/10.1038/sj.bjc.6604222
 
[8]Crombet, T., Torres, L., Neninger, E., et al. (2003) Pharmacological Evaluation of Humanized Anti-Epidermal Growth Factor Receptor, Monoclonal Antibody h-R3, in Patients with Advanced Epithelial-Derived Cancer. Journal of Immunotherapy, 26, 139-148. http://dx.doi.org/10.1097/00002371-200303000-00006
 
[9]Crombet, T., Osorio, M., Cruz, T., et al. (2004) Use of the Humanized Anti-Epidermal Growth Factor Receptor Monoclonal Antibody h-R3 in Combination with Radiotherapy in the Treatment of Locally Advanced Head and Neck Cancer Patients. Journal of Clinical Oncology, 22, 1646-1654.
http://dx.doi.org/10.1200/JCO.2004.03.089                                                          eww150202lx
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