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The Effect of Soy Nuts on Glycemic Control, Lipid Profile and Insulin-Resistance in Type 2 Diabetic Patients

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ABSTRACT
Type 2 diabetes has a high prevalence and a growing trend. The use of a proper diet treatment is one of the therapeutic approaches of patients. The use of the soy has shown the effective results in glycemic control of patients with type 2 diabetes; however, data are paradoxical. The present study aimed to examine the effectiveness of soy nuts on glycemic control, blood pressure and lipid profile and insulin-resistance of the diabetic patients<span "="">.<span "=""> Methods: In this case-control study 69 type 2 diabetic patients were randomly divided into two groups: intervention (n = 35) and control (n = 34). The patients in the intervention group substituted 60 grams of soy nuts as a part of the daily protein requirement for eight weeks. In contrast, the patients in the control group received usual diet of diabetes (no soy)<span "="">.<span "=""> The drugs received by patients had not been changed during the intervention period. Before and at the end of the intervention, Hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), serum insulin levels, insulin-resistance, systolic and diastolic blood pressure, low density lipoprotein-cholesterol (LDL-c), high density lipoprotein-cholesterol (HDL-c) and total cholesterol, and triglycerides (TG) were measured in the patients. Insulin-resistance was calculated by Homeostatic model assessment-IR formula (HOMA-IR)<span "="">.<span "=""> <span "="">Results: Soy consumption significantly lowered FPG (P = 0.03), HbA1c (P < 0.01), plasma insulin levels (P = 0.01), insulin-resistance (P = 0.01), total cholesterol (P < 0.01) and LDL-c (P = 0.01), but did not have any significant effect on systolic blood pressure (P = 0.4), diastolic blood pressure (P = 0.2), HDL-c (P = 0.4) and TG (P = 0.2)<span "="">.<span "=""> Conclusion: Consumption of soy nuts in type 2 diabetic patients can cause an improvement in the glycemic control and insulin-resistance, and the lipid profile does not have any significant effect on blood pressure.
 
Cite this paper
Sedaghat, A. , Shahbazian, H. , Haidari, F. , Payami, S. , Jahanshahi, A. and Latifi, S. (2015) The Effect of Soy Nuts on Glycemic Control, Lipid Profile and Insulin-Resistance in Type 2 Diabetic Patients. Open Journal of Endocrine and Metabolic Diseases, 5, 1-7. doi: 10.4236/ojemd.2015.51001.
 
References
[1]Melmed, S., Polonsky, K.S., Reed Larsen, P. and Kronenberg, H.M. (2011) Williams Textbook of Endocrinology: Expert Consult. Elsevier Health Sciences, 1701-1703.
 
[2]Yang, W., Dall, T.M., Halder, P., Gallo, P., Kowal, S.L. and Hogan, P.F. (2013) Economic Costs of Diabetes in the U.S. in 2012. Diabetes Care, 36, 1033-1046. http://dx.doi.org/10.2337/dc12-2625
 
[3]Stone, N.J. and Van Horn, L. (2002) Therapeutic Lifestyle Change and Adult Treatment Panel III: Evidence Then and Now. Current Atherosclerosis Reports, 4, 433-443. http://dx.doi.org /10.1007/s11883-002-0047-x
 
[4]Hermansen, K., Sondergaard, M., Hoie, L., Carstensen, M. and Brock, B. (2001) Beneficial Effects of a Soy-Based Dietary Supplement on Lipid Levels and Cardiovascular Risk Markers in Type 2 Diabetic Subjects. Diabetes Care, 24, 228-233. http://dx.doi.org/10.2337/diacare.24.2.228
 
[5]Shahbazian, H., Reza, A., Javad, S., Heshmatollah, S., Mahmood, L., Ali, A. and Hosain, H.M. (2007) Beneficial Effects of Soy Protein Isoflavones on Lipid and Blood Glucose Concentrations in Type 2 Diabetic Subjects. Saudi Medical Journal, 28, 652-654.
 
[6]Chang, J.H., Kim, M.S., Kim, T.W. and Lee, S.S. (2008) Effects of Soybean Supplementation on Blood Glucose, Plasma Lipid Levels, and Erythrocyte Antioxidant Enzyme Activity in Type 2 Diabetes Mellitus Patients. Nutrition Research and Practice, 2, 152-157. http://dx.doi.org/10.4162/nrp.2008.2.3.152
 
[7]Clerici, C., Nardi, E., Battezzati, P.M., Asciutti, S., Castellani, D., Corazzi, N., Giuliano, V., et al. (2011) Novel Soy germ Pasta Improves Endothelial Function, Blood Pressure, and Oxidative Stress in Patients with Type 2 Diabetes. Diabetes Care, 34, 1946-1948. http://dx.doi.org/10.2337/dc11-0495
 
[8]Liu, Z., Chen, Y., Ho, S.C., Ho, Y.P. and Woo, J. (2010) Effects of Soy Protein and Isoflavones on Glycemic Control and Insulin Sensitivity: A 6-mo Double-Blind, Randomized, Placebo-Controlled Trial in Postmenopausal Chinese Women with Prediabetes or Untreated Early Diabetes. The American Journal of Clinical Nutrition, 91, 1394-1401. http://dx.doi.org/10.3945/ajcn.2009.28813
 
[9]Jayagopal, V., Albertazzi, P., Kilpatrick, E.S., Howarth, E.M., Jennings, P.E., Hepburn, D.A., et al. (2002) Beneficial Effects of Soy Phytoestrogen Intake in Postmenopausal Women with Type 2 Diabetes. Diabetes Care, 25, 1709-1714. http://dx.doi.org/10.2337/diacare.25.10.1709
 
[10]Liao, F.H., Shieh, M.J., Yang, S.C., Lin, S.H. and Chien, Y.W. (2007) Effectiveness of a Soy-Based Compared with a Traditional Low-Calorie Diet on Weight Loss and Lipid Levels in Overweight Adults. Nutrition, 23, 551-556. http://dx.doi.org/10.1016/j.nut.2007.05.003
 
[11]Kwak, J.H., Kim, M., Lee, E., Lee, S.H., Ahn, C.W. and Lee, J.H. (2013) Effects of Black Soy Peptide Supplementation on Blood Pressure and Oxidative Stress: A Randomized Controlled Trial. Hypertension Research, 36, 1060-1066. http://dx.doi.org/10.1038/hr.2013.79
 
[12]Reynolds, K., Chin, A., Lees, K.A., Nguyen, A., Bujnowski, D. and He, J. (2006) A Meta-Analysis of the Effect of Soy Protein Supplementation on Serum Lipids. American Journal of Cardiology, 98, 633-640. http://dx.doi.org/10.1016/j.amjcard.2006.03.042
 
[13]Welty, F.K., Lee, K.S., Lew, N.S. and Zhou, J.R. (2007) Effect of Soy Nuts on Blood Pressure and Lipid Levels in Hypertensive, Prehypertensive, and Normotensive Postmenopausal Women. Archives of Internal Medicine, 167, 1060-1067. http://dx.doi.org/10.1001/archinte.167.10.1060
 
[14]Nasca, M.M., Zhou, J.R. and Welty, F.K. (2008) Effect of Soy Nuts on Adhesion Molecules and Markers of Inflammation in Hypertensive and Normotensive Postmenopausal Women. American Journal of Cardiology, 102, 84-86. http://dx.doi.org/10.1016/j.amjcard.2008.02.100
 
[15]Stas, S.N., El-Atat, F.A. and Sowers, J.R. (2004) Pathogenesis of Hypertension in Diabetes. Reviews in Endocrine and Metabolic Disorders, 5, 221-225. http://dx.doi.org/10.1023/ B:REMD.0000032410.75638.da
 
[16]Mooradian, A.D. (2009) Dyslipidemia in Type 2 Diabetes Mellitus. Nature Clinical Practice Endocrinology & Metabolism, 5, 150-159. http://dx.doi.org/10.1038/ncpendmet1066
 
[17]Tabatabaei-Malazy, O., Larijani, B. and Abdollahi, M. (2012) A Systematic Review of in Vitro Studies Conducted on Effect of Herbal Products on Secretion of Insulin from Langerhans Islets. Journal of Pharmaceutical Sciences, 15, 447-466.
 
[18]Ascencio, C., Torres, N., Isoard-Acosta, F., Gómez-Pérez, F.J., Hernández-Pando, R. and Tovar, A.R. (2004) Soy Protein Affects Serum Insulin and Hepatic SREBP-1 mRNA and Reduces Fatty Liver in Rats. Journal of Nutrition, 134, 522-529.
 
[19]Noriega-López, L., Tovar, A.R., Gonzalez-Granillo, M., Hernández-Pando, R., Escalante, B., Santillán-Doherty, P., et al. (2007) Pancreatic Insulin Secretion in Rats Fed a Soy Protein High Fat Diet Depends on the Interaction between the Amino Acid Pattern and Isoflavones. Journal of Biological Chemistry, 282, 20657-20666. http://dx.doi.org/10.1074/jbc.M701045200
 
[20]Cederroth, C.R. and Nef, S. (2009) Soy, Phytoestrogens and Metabolism: A Review. Molecular and Cellular Endocrinology, 304, 30-42.
 
[21]Tsai, A.C., Mott, E.L., Owen, G.M., Bennick, M.R., Lo, G.S. and Steinke, F.H. (1983) Effects of Soy Polysaccharide on Gastrointestinal Functions, Nutrient Balance, Steroid Excretions, Glucose Tolerance, Serum Lipids, and Other Parameters in Humans. American Journal of Clinical Nutrition, 38, 504-511.
 
[22]Azadbakht, L., Kimiagar, M., Mehrabi, Y., Esmaillzadeh, A., Hu, F.B. and Willett, W.C. (2007) Soy Consumption, Markers of Inflammation, and Endothelial Function: A Cross-Over Study in Postmenopausal Women with the Metabolic Syndrome. Diabetes Care, 30, 967-973. http://dx.doi.org/10.2337/dc06-2126
 
[23]Ali, A.A., Velasquez, M.T., Hansen, C.T., Mohamed, A.I. and Bhathena, S.J. (2005) Modulation of Carbohydrate Metabolism and Peptide Hormones by Soybean Isoflavones and Probiotics in Obesity and Diabetes. Journal of Nutritional Biochemistry, 16, 693-699. http://dx.doi.org/10.1016/j.jnutbio.2005.03.011
 
[24]Azadbakht, L. and Esmaillzadeh, A. (2012) Soy Intake and Metabolic Health: Beyond Isoflavones. Archives of Iranian Medicine, 15, 460-461.                                                                                          eww150123lx
 
[25]Anderson, J.W., Baird, P., Davis Jr., R.H., Ferreri, S., Knudtson, M., Koraym, A., et al. (2009) Health Benefits of Dietary Fiber. Nutrition Reviews, 67, 188-205. http://dx.doi.org/10.1111/j.1753-4887.2009.00189.x
 
[26]Meyer, K.A., Kushi, L.H., Jacobs Jr., D.R., Slavin, J., Sellers, T.A. and Folsom, A.R. (2000) Carbohydrates, Dietary Fiber, and Incident Type 2 Diabetes in Older Women. American Journal of Clinical Nutrition, 71, 921-930.
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