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http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53522#.VMdI-SzQrzE
Affiliation(s)
1Department of Podiatric Medicine and Surgery, Yale New Haven Hospital/DVA West Haven, New Haven, CT, USA.
2Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
2Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
ABSTRACT
Objective:
Onychomycosis is a diagnosis of fungal organisms in the nail unit. It
frequently occurs in both the immunocompetent and immunocompromised
patient. A variant of onychomycosis is proxiaml onychomycosis that
occurs on the most proximal aspect of the nail. Proximal onychomycosis
is known to be commonly associated with immunocompromised status. Study
Design: A case report of a veteran who presented a dermatology clinic
with complaint of solitary nail discoloration that was recalcitrant to
over-the-counter therapy including topical hydrogen peroxide and foot
soaks without improvement. Results and Conclusions: This individual case
report demonstrates that pedal proximal onychomycosis can be associated
with non-dermatophyte organisms, identified as Fusarium species, in
immunocompetent individuals. The finding of pedal proximal onychomycosis
caused by a Fusarium non-dermatophytic mold has not been reported. The
veteran was successfully cured of the condition with treatment via oral
terbinafine for a ninety-day course while monitoring patient’s liver
function test for any complications.
Cite this paper
References
Schmidt, B. and Holmes, C. (2015) Proximal White Onychomycosis in an Immunocompetent Patient: A Case Report. Case Reports in Clinical Medicine, 4, 41-44. doi: 10.4236/crcm.2015.41010.
| [1] | Ahn, K.J. (1994) A Case of White Superficial Onychomycosis. Korean Journal of Dermatology, 32, 931-933. |
| [2] | Habif, T.P., Ed. (2010) Clinical Dermatology. 5th Edition, Saunders Elsevier, Philadelphia, 491-523. |
| [3] | Hay, R.J. (2009) Dermatophytosis and Other Superficial Mycoses. In: Mandell, G.L., Bennett, J.E. and Dolin, R., Eds., Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th Edition, Churchill Livingstone Elsevier, Philadelphia, Chapter 267. |
| [4] | Phillips, P. (1996) New Drugs for the Nail Fungus Prevalent in Elderly. JAMA, 276, 12-13. http://dx.doi.org/10.1001/jama.1996.03540010014007 |
| [5] | Elewski, B.E. and Hay, R.L. (1996) Update on the Management of Onychomycosis: Highlights of the Third Annual International Summit on Cutaneous Antifungal Therapy. Clinical Infectious Diseases, 23, 305-313. |
| [6] | Zaias, N., Glick, B. and Rebell, G. (1996) Diagnosing and Treating Onychomycosis. The Journal of Family Practice, 42, 513-518. |
| [7] | Gupta,
A.K., Taborda, P., Taborda, V., Gilmour, J., Rachlis, A., Salit, I., et
al. (2000) Epidemiology and Prevalence of Onychomycosis in HIV-Positive
Individuals. International Journal of Dermatology, 39, 746-753. http://dx.doi.org/10.1046/j.1365-4362.2000.00012.x |
| [8] | Tlacuilo-Parra, A., Guevara-Gutierrez, E., Mayorga, J., Garcia-De La Torre, I. and Salazar-Paramo, M. (2003) Onychomycosis in Systemic Lupus Erythematosus: A Case Control Study. The Journal of Rheumatology, 30, 1491-1494. |
| [9] | Schlefman, B.S. (1999) Onychomycosis: A Compendium of Facts and a Clinical Experience. The Journal of Foot & Ankle Surgery, 38, 290-302. http://dx.doi.org/10.1016/S1067-2516(99)80072-6 |
| [10] | Odom, R.B. (1996) New Therapies for Onychomycosis. Journal of the American Academy of Dermatology, 35, S26-S30. http://dx.doi.org/10.1016/S0190-9622(96)90067-5 |
| [11] | Elewski, B.E. (1993) Clinical Pearl: Proximal White Subungual Onychomycosis in AIDS. Journal of the American Academy of Dermatology, 29, 631-632. http://dx.doi.org/10.1016/S0190-9622(08)81867-1 |
| [12] | Weinberg, J.M., Koestenblatt, E.K., Don, P.C., White, S.M., Stein, M.N. and Bamji, M. (1999) Proximal White Subungual Onychomycosis in the Immunocompetent Patient: Report of Two Cases and Review of the Literature. Acta Dermato-Venereologica, 79, 81-95. |
| [13] | Piraccini,
B.M., Morelli, R., Stinchi, C. and Tosti, A. (1996) Proximal Subungual
Onychomycosis Due to Microsporum canis. British Journal of Dermatology,
134, 175-177. http://dx.doi.org/10.1111/j.1365-2133.1996.tb07863.x |
| [14] | Baran,
R., Tosti, A. and Piraccini, B.M. (1997) Uncommon Clinical Patterns of
Fusarium Nail Infection: Report of Three Cases. British Journal of
Dermatology, 136, 424-427. http://dx.doi.org/10.1111/j.1365-2133.1997.tb14959.x |
| [15] | Dordrain-Bigot, M.L., Baran, R., Baixench, M.T. and Bazex, J. (1996) Fusarium Onychomycosis. Annales De Dermatologie et De Venereologie, 123, 191-193. |
| [16] | Silver-Lizama,
E. and Logemann, H. (1996) Proximal White Subungual Onychomycosis in
AIDS. International Journal of Dermatology, 35, 290-291. http://dx.doi.org/10.1111/j.1365-4362.1996.tb03006.x |
| [17] | Noppakun,
N.M. and Head, E.E. (1986) Proximal White Subungual Onychomycosis in a
Patient with Acquired Immune Deficiency Syndrome. International Journal
of Dermatology, 25, 586-587. http://dx.doi.org/10.1111/j.1365-4362.1986.tb04705.x |
| [18] | Tosti,
A., Piracinni, B.M. and Lorenzi, S. (2000) Onychomycosis Caused by
Nondermatophytic Molds: Clinical Features and Response to Treatment of
59 Cases. Journal of the American Academy of Dermatology, 42, 217-224. http://dx.doi.org/10.1016/S0190-9622(00)90129-4 |
| [19] | Hilmioglu-Polat,
S., Metin, D.Y., Inci, R., Dereli, T., Kilinc, I. and Tümbay, E. (2005)
Non-Dermatophytic Molds as Agents of Onychomycosis in Izmir, Turkey—A
Prospective Study. Mycopathologia, 160, 125-128. http://dx.doi.org/10.1007/s11046-005-6872-z |
| [20] | Gupta,
A.K., Jain, H.C., Lynde, C.W., Macdonald, P., Cooper, E.A. and
Summerbell, R.C. (2000) Prevalence and Epidemiology of Onychomycosis in
Patients Visiting Physicians’ Offices: A Multicenter Canadian Survey of
15,000 Patients. Journal of the American Academy of Dermatology, 43,
244-248. http://dx.doi.org/10.1067/mjd.2000.104794 eww150127lx |
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