跳至主要内容

Fixed Dose Rate versus Standard Dose Rate Infusion of Gemcitabine and Cisplatin in Advanced Stage Non-Small Cell Lung Cancer

Read  full  paper  at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52991#.VK86AcnQrzE

ABSTRACT
<span "="">Background: Comparing the efficacy and safety of gemcitabine at a fixed-dose rate (FDR) infusion (10 mg/m2/min) with the standard dose rate infusion in patients with locally advanced and metastatic non-small squamous cell carcinoma (NSCLC). Methods: The study randomized 60 patients with confirmed diagnosis of NSCLC to receive gemcitabine at a dose of 1000 mg/m2 on days 1 and 8 given as a 30-min infusion (Arm A) or at a rate of 10 mg/m2/min (Arm B). Cisplatin 75 mg/m2 was administered intravenously on day 2 in both arms. Results: No difference in overall response rate (46.6% versus 43.3%). Median time to progression for Arm A was 7 months (95% CI, 6.207 - 7.793 months), versus 6 months for Arm B (95% CI, 4.990 - 7.010 months). Median survival time was comparable [12 months (95% CI, 8.588 - 15.412 months) versus 11 months (95% CI, 9.066 - 12.934 months)] respectively. Two-year survival (18% versus 11%, <span "=""><span "="">p<span "=""> <span "="">= 0.38) was detected. No treatment related deaths occurred. Main hematological toxicities were grade I and II neutropenia, in 36.7% and 53.3% respectively (<span "=""><span "="">p<span "=""> <span "="">= 0.044). Grade III anemia was observed in 10% and 6.7% in both arms respectively (<span "=""><span "="">p<span "=""> <span "="">= 0.024). Grade I and II nausea and vomiting was observed in 50% and 46.7%. Conclusions: FDR gemcitabine in combination with cisplatin had equivalent efficacy and more severe hematologic toxicities compared to the standard 30-min gemcitabine infusion with cisplatin in patients with advanced NSCLC.
 
Cite this paper
Salem, D. , Ibrahim, D. , Ezzat, A. and Adel, A. (2015) Fixed Dose Rate versus Standard Dose Rate Infusion of Gemcitabine and Cisplatin in Advanced Stage Non-Small Cell Lung Cancer. Journal of Cancer Therapy, 6, 45-52. doi: 10.4236/jct.2015.61007.
 
References
[1]Siegel, R.L., Naishadham, D. and Jamal, A. (2012) Cancer Statistics. CA: A Cancer Journal for Clinicians, 62, 10-29. http://dx.doi.org/10.3322/caac.20138
 
[2]Ferlay, J., Shin, H.R., Bary, F., et al. (2010) GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10. International Agency for Research on Cancer, Lyon. http://globocan.iarc.fr/
 
[3]Greene, F.L., Page, D.L., Fleming, I.D., Firtz, A., Balch, D.G. and Haller, M.M. (2002) AJCC Cancer Staging Manual. 6th Edition, Springer-Verlag, Berlin/Heidelberg/New York/London/Paris/Tokyo/Hong Kong, 435.
 
[4]Arriagada, R., Auperin, A., Burdett, S., Higgins, J.P., Johnson, D.H., Le Chevalier, T., Le Pechoux, C., Pamar, M.K., Pignon, P.J., Souhami, R.L., Stephens, R.J., Stewart, L.A., Tierney, J.F., Tribodet, H. and van Meerbeeck, J., On Behalf of the NSCLC Meta-Analyses Collaborative Group (2010) Adjuvant Chemotherapy with or witout Postoperative Radiotherapy in Operable Non-Small-Cell Lung Cancer: Two Meta-Analyses of Individual Patient Data. Lancet, 375, 1267-1277. http://dx.doi.org/10.1016/S0140-6736(10)60059-1
 
[5]Scagliotti, G.V., De Marinis, F., Rinaldi, M., Crino, L., Gridelli, C., Ricci, S., Matano, E., Boni, C., Marangolo, M., Failla, G., Altavilla, G., Adamo, V., Ceribelli, A., Clerici, M., Di Costanzo, F., Frontini, L. and Tona, M. (2002) Phase III Randomized Trial Comparing Three Platinum-Based Doublets in Advanced Non-Small Cell Lung M. Cancer Italian Lung Cancer Project. Journal of Clinical Oncology, 20, 4285-4291.
http://dx.doi.org/10.1200/JCO.2002.02.068
 
[6]Pastor-Anglada, M., Molina-Arcas, M., Casado, F.J., Bellosillo, B., Colomer, D. and Gil, J. (2004) Nucleoside Transporters in Chronic Lymphocytic Leukemia. Leukemia, 18, 385-393.
http://dx.doi.org/10.1038/sj.leu.2403271
 
[7]Abratt, R.P., Bezwoda, W.R., Falkson, G., Goedhals, L., Hacking, D. and Rugg, T.A. (1994) Efficacy and Safety Profile of Gemcitabine in Non-Small-Cell Lung Cancer: A Phase II Study. Journal of Clinical Oncology, 12, 1535-1540.
 
[8]Tempero, M., Plunkett, W., Ruiz Van Haperen, V., Hainsworth, J., Lenzi, R. and Abbruzzese, J. (2003) Randomized Phase II Comparison of Dose-Intense Gemcitabine: Thirty-Minute Infusion and Fixed Dose Rate Infusion in Patients with Pancreatic Adenocarcinoma. Journal of Clinical Oncology, 21, 3402-3408. http://dx.doi.org/10.1200/JCO.2003.09.140
 
[9]Ceribelli, A., Gridelli, C., De Marinis, F., Fabi, A., Gamucci, T., Cortesi, E., Barduagni, M., Antimi, M., Maione, P., Migliorino, M.R., Giannarelli, D. and Cognetti, F. (2003) Prolonged Gemcitabine Infusion in Advanced Non-Small Cell Lung Carcinoma: A Randomized Phase II Study of Two Different Schedules in Combination with Cisplatin. Cancer, 98, 337-343. http://dx.doi.org/10.1002/cncr.11501
 
[10]Cappuzzo, F., Novello, S., De Marinis, F., Selvaggi, G., Scagliotti, G.V., Barbieri F., Maur, M., Papi, M., Bartolini, S., Marini, L. and Crino, L. (2006) A Randomized Phase II Trial Evaluating Standard (50 mg/min) versus Low (10 mg/min) Infusion Duration of Gemcitabine as First-Line Treatment in Advanced Non-Small-Cell Lung Cancer Patients Who Are Not Eligible for Platinum-Based Chemotherapy. Lung Cancer, 52, 319-325. http://dx.doi.org/10.1016/j.lungcan.2006.03.004
 
[11]Soo, R.A., Wang, L.Z., Tham, L.S., Yong, W.P., Boyer, M., Lim, H.L., Lee, H.S., Millward, M., Liang, S., Beale, P., Lee, S.C. and Goh, B.C. (2006) A Multicenter Randomized Phase II Study of Carboplatin in Combination to Gemcitabine at Standard Rate or Fixed Dose Rate Infusion in Patients with Advanced Stage Non-Small-Cell Lung Cancer. Annals of Oncology, 17, 128-133. http://dx.doi.org/10.1093/annonc/mdl084
 
[12]Gridelli, C., Gallo, C., Ceribelli, A., Gebbia, V., Gamucci, T., Ciardiello, F., Carozza, F., Favaretto, A., Daniele, B., Galetta, D., Barbera, S., Rosette, F., Rossi, A., Maione, P., Cognetti, F., Testa, A., Di Maio, M., Morabito, A., Perrone, F. and GECO Investigators (2007) Factorial Phase III Randomized Trial of Rofecoxib and Prolonged Constant Infusion of Gemcitabine in Advanced Non-Small-Cell Lung Cancer: The GEmcitabine-COxib in NSCLC (GECO) Study. Lancet Oncology, 8, 500-512. http://dx.doi.org/10.1016/S1470-2045(07)70146-8
 
[13]Wang, L.R., Huang, M.Z., Zhang, G.B., Xu, N. and Wu, X.H. (2007) Phase II Study of Gemcitabine and Carboplatin in Patients with Advanced Non-Small-Cell Lung Cancer. Cancer Chemotherapy and Pharmacology, 60, 601-607. http://dx.doi.org/10.1007/s00280-007-0504-x
 
[14]Pereira, J.R., Fein, L., Del Giglio, A., Blajman, C.R., Richardet, E., Schwartsmann, G., Orlando, M., Hall, B.J., West, T.M. and van Kooten, M. (2007) Gemcitabine Administered as a Short Infusion versus a Fixed Dose Rate in Combination with Cisplatin for the Treatment of Patients with Advanced Non-Small Cell Lung Cancer. Lung Cancer, 58, 80-87. http://dx.doi.org/10.1016/j.lungcan.2007.05.004
 
[15]Therasse, P., Arbuck, S.G., Eisenhauer, E.A., Wanders, J., Kaplan, R.S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A.T., Christian, M.C. and Gwyther, S.G. (2000) New Guidelines to Evaluate the Response to Treatment in Solid Tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. Journal of the National Cancer Institute, 92, 205-216. http://dx.doi.org/10.1093/jnci/92.3.205
 
[16](2003) Cancer Therapy Evaluation Program, Common Terminology Criteria for Adverse Events, Version 3.0, DCTD, NCI, NIH, DHHS. http://cte b.cancer.gov
 
[17]Qui, M.T., Ding, X.X., Hu, J.W., Tian, H.Y., Yin, R. and Xu, L. (2012) Fixed-Dose Rate Infusion and Standard Rate Infusion of Gemcitabine in Patients with Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis of Six Trials. Cancer Chemotherapy and Pharmacology, 70, 861-873. http://dx.doi.org/10.1007/s00280-012-1974-z
 
[18]Xu, N., Shen, P., Zhang, X.C., Yu, L.F., Bao, H.Y., Shi, G.M., Huanq, S., Chen, J., Mou, H.B. and Fang, W.J. (2007) Phase II Trial of a 2-h Infusion of Gemcitabine plus Carboplatin as First-Line Chemotherapy for Advanced Non-Small-Cell Lung Cancer. Cancer Chemotherapy and Pharmacology, 59, 1-7.
http://dx.doi.org/10.1007/s00280-006-0237-2
 
[19]Tibaldi, C., Bernardini, I., Chella, A., Russo, F., Toma, G., Tempestini, F., Malventi, M., Vasile, E, Ambrosino, N. and Falcone, A. (2006) Prolonged Gemcitabine Infusion in Advanced Non-Small-Cell Lung Cancer with Stable Disease after Gemcitabine 30-Min Infusion. Lung Cancer, 51, 217-223.
http://dx.doi.org/10.1016/j.lungcan.2005.10.013                                                                     eww150109lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文