跳至主要内容

Effect of the Ethanolic Extract of Khaya senegalensis on Some Biochemical Parameters on Rabbit’s in Glucose Overload Condition

Read  full  paper  at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53530#.VMdL9CzQrzE

ABSTRACT
The effect of the ethanolic extract Khaya senegalensis on some biochemical parameters was tested in rabbits with normal glucose and glucose overload. Phytochemical screening after three batches of 6 rabbits race (TBD) were treated with the extract in oral doses of respectively 10, 25 and 50 mg/kg body weight for 30 days; three other groups receiving respectively these doses of the extract were placed under a priori temporary overload of glucose; a control group received instead distilled water treatment. Blood glucose, triglycerides and total cholesterol were measured by spectrophotometry and weight gain of the animals was performed at the beginning of the experiment and every 2 weeks during the study period. The phytochemical screening revealed the presence of polyphenolic compounds (majority) of saponins of anthracene derivatives and steroids in the extract. The test results indicate that under the dose of 50 mg/kg body weight (BW) there was a significant decrease (p < 0.05) in blood glucose after 24 hours. The extract had no effect on the lipid profile or body weight of rabbits.
 
Cite this paper
Agossou, E. , Ahokpe, M. , Behanzin, J. , Takin, M. , Yessoufou, G. , Zohoun, L. , Baba-Moussa, L. and Sezan, A. (2015) Effect of the Ethanolic Extract of Khaya senegalensis on Some Biochemical Parameters on Rabbit’s in Glucose Overload Condition. American Journal of Plant Sciences, 6, 240-248. doi: 10.4236/ajps.2015.61027.
 
References
[1]Musa, H.R., Ambroggi, M., Souto, A. and Angeby, K.A. (2005) Drug Susceptibility Testing of Mycobacterium Tuberculosis by Nitrate Reductase Essay Applied Directly on Microscopy-Positive Sputum Sample. Journal of Clinical Microbiology, 43, 3159-3161. http://dx.doi.org/10.1128/JCM.43.7.3159-3161.2005
 
[2]Sharma, B., Viswanath, G., Salunke, R. and Roy, P. (2008) Effects of Flavonoid-Rich Extract from Seeds of Eugenia jambolana (L.) on Carbohydrate and Lipid Metabolism in Diabetic Mice. Food Chemistry, 110, 697-705. http://dx.doi.org/10.1016/j.foodchem.2008.02.068
 
[3]Guermaz, R., Zekri, S., Hatri, A., Kessal, F. and Brouri, M. (2008) Le diabète de type 2 en Algérie: Poids actuel et à venir. La Revue de Médecine Interne, 29, S49-S50.
http://dx.doi.org/10.1016/j.revmed.2008.03.087
 
[4]Singh, J. and Kakkar, P. (2009) Antihyperglycemic and Antioxidant Effect of Berberis aristata Root Extract and Its Role in Regulating Carbohydrate Metabolism in Diabetic Lapins. Journal of Ethnopharmacology.
 
[5]Zhou, I., Zhou, S., Tang, J., Zhang, K., Guang, L., Huang, Y., Xu, Y., Ying, Y., Zhang, L. and Li, D. (2009) Protective Effect of Berberine on Beta Cells in Streptozotocin- and High-Carbohydrate/High-Fat Diet-Induced Diabetic Lapins. European Journal of Pharmacology, 606, 262-268.
http://dx.doi.org/10.1016/j.ejphar.2008.12.056
 
[6]Sarkhail, P., et al. (2007) Antidiabetic Effect of Phlomis anisodonta: Effects on Hepatic Cells Lipid Peroxidation and Antioxidant Enzymes in Experimental Diabetes. Pharmacological Research, 56, 261-266. http://dx.doi.org/10.1016/j.phrs.2007.07.003
 
[7]Bahorun, T. (1997) Substances naturelles actives: La flore mauricienne, une source d’approvisionnement potentielle. Food and Agricultural Research, 83-94.
 
[8]Gill, L.S. (1992) Ethnomedical Uses of Plants in Nigeria. Uniben Press, Benin City, 15-65.
 
[9]Maydell, H.J. (1986) Trees and Shrubs of Sahel-Thier Charactérisatics and Uses. Gesdtschaft, Fur, Germany, 105-110.
 
[10]Kolawole, S.O., et al. (2011) Effects of Aqueous Extract of Khaya senegalensis Stem Bark on Biochemical and Hematological Parameters in Rats. Journal of Pharmacological and Toxicological Methods, 6, 602-607.
 
[11]Adebayo, J.O., Yacubu, M.T., Egwin, E.C., Owoyele, V.B. and Enaibe, B.U. (2003) Effect of Ethanolic Extract of Khaya senegalensis on Some Biochemical Parameters of Rat Kidney. Journal of Ethnopharmacology, 88, 69-72. http://dx.doi.org/10.1016/S0378-8741(03)00193-4
 
[12]Lompo, M., Dubois, J. and Guissou, I.P. (2007) In Vitro Preliminary Study of Free Radical Scavenging Activity of Extracts from Khaya senegalensis A. Juss. Journal of Biological Sciences, 7, 677-680. http://dx.doi.org/10.3923/jbs.2007.677.680
 
[13]Houghton, P.J. and Raman, A. (1998) Laboratory Handbook for Fractionation of Natural Extracts. Chapman and Hall, London, 199 p.
 
[14]Allain, C.C., Poon, L.S., Chan, C.S., Richmond, W. and Fu, P.C. (1974) Enzymatic Determination of Total Serum Cholesterol. Clinical Chemistry, 20, 470-475.
 
[15]Al-Achi, A. (2005) Herbs that Affect Blood Glucose Level. Women’s Health in Primary Care, 8, 325-330.
 
[16]Pari, L. and Venkateswaran, S. (2002) Hypoglycaemic Activity of Scoparia dulcis L. Extract in Alloxan Induced Hyperglycaemic Rats. Phytotherapy Research, 16, 662-664.
 
[17]Waltner-Law, M.E., Wang, X.L., Law, B.K., Hall, R.K., Nawano, M. and Granner, D.K. (2002) Epigallocatechin Gallate, a Constituent of Green Tea, Represses Hepatic Glucose Production. Journal of Biological Chemistry, 277, 34933- 34940. http://dx.doi.org/10.1074/jbc.M204672200
 
[18]Vergès, B. (2007) Physiopathologie de la dyslipidémie du syndrome métabolique et du diabète de type 2. Nutrition Clinique et Métabolisme, 21, 9-16. http://dx.doi.org/10.1016/j.nupar.2007.01.011                  eww150127lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文