跳至主要内容

Curcumin: New Weapon against Cancer

Read  full  paper  at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52897#.VKyRTcnQrzE

Author(s)  

ABSTRACT
All the evidences point out to the fact that the incidence, mortality and number of persons living with cancer are on the rise and, thus, this will impose a significant burden on health care resources. The considerable number of deaths from cancer necessitates the need to developing novel alternative cures that are efficient, safe, cheap and easy to use. In the search for new therapies for tumors, naturally-derived compounds have been considered as a good source of novel anticancer drugs. The challenge here is to find products that are pharmacologically active against tumor cells with suitable toxicity profile and least damage to normal cells. Curcumin is a spice widely used in many countries especially in South Asia and it has gained importance for its anticancer function and low toxicity toward normal tissues in a range of biological systems. In spite of significant research works, many difficulties hinder its oral use in the therapy of different kind of tumors, such as extreme low solubility in water, quick break down and excretion after being absorbed in the human body. Low bioavailability due to enhanced metabolism and rapid system elimination is another problem that hinders oral use of curcumin as anticancer agent. Therefore, the previously mentioned poor pharmacokinetics characteristics inhibit curcumin from reaching its site of action and, thus, lessen its effectiveness against tumors. This article reviews the latest global cancer statistics with special attention to be directed toward ovarian cancer. It sheds light on many research works that investigated the protective and therapeutic functions of different curcumin preparations against different sites of cancer using animal models. It also summarizes recent research works concerning the antitumor effects of curcumin alone and/or loaded into a range of delivery devices in many types of ovarian cancer cell lines. In the last section, it discusses the latest research work with regard ovarian cancer in the kingdom of Saudi Arabia.
 
Cite this paper
Hamam, F. (2014) Curcumin: New Weapon against Cancer. Food and Nutrition Sciences, 5, 2257-2264. doi: 10.4236/fns.2014.522239.
 
References
[1]Sankaranarayanan, R. and Ferlay, J. (2006) Worldwide Burden of Gynaecological Cancer: The Size of the Problem. Best Practice & Research Clinical Obstetrics & Gynaecology, 20, 207-225.
http://dx.doi.org/10.1016/j.bpobgyn.2005.10.007
 
[2]Siegel, R., Ma, J., Zou, Z. and Jemal, A. (2014) Cancer Statistics, 2014. CA: A Cancer Journal for Clinicians, 64, 9-29.
http://dx.doi.org/10.3322/caac.21208
 
[3]Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E. and Forman, D. (2011) Global Cancer Statistics. CA: A Cancer Journal for Clinicians, 61, 69-90.
http://dx.doi.org/10.3322/caac.20107
 
[4]Zheng, L.D., Tong, Q.S. and Wu, C.H. (2004) Growth-Inhibitory Effects of Curcumin on Ovary Cancer Cells and Its Mechanisms. Journal of Huazhong University of Science and Technology, 24, 55-58.
http://dx.doi.org/10.1007/BF02830706
 
[5]Zheng, L.D., Tong, Q.S. and Wu, C.H. (2006) Growth Inhibition and Apoptosis Inducing Mechanisms of Curcumin on Human Ovarian Cancer Cell Line A2780. Chinese Journal of Integrative Medicine, 12, 126-131.
http://dx.doi.org/10.1007/BF02857359
 
[6]Cai, Q., Shi, M., Yao, L., Mao, Y., Ming, Y. and Ouyang, G. (2006) Antiproliferation and Apoptosis Induced by Curcumin in Human Ovarian Cancer Cells. Cell Biology International, 30, 221-226.
 
[7]Sun, M., Su, X., Ding, B., He, X., Liu, X., Yu, A., Lou, H. and Zhai, G. (2012) Advances in Nanotechnology-Based Delivery Systems for Curcumin. Nanomedicine, 7, 1085-1100.
http://dx.doi.org/10.2217/nnm.12.80
 
[8]Sharma, R.A., Gescher, A.J. and Steward, W.P. (2005) Curcumin: The Story So Far. European Journal of Cancer, 41, 1955-1968.
http://dx.doi.org/10.1016/j.ejca.2005.05.009
 
[9]Ghosh, D., Choudhury, S.T., Ghosh, S., Mandal, A.K., Sarkar, S., Ghosh, A., Saha, K.D. and Das, N. (2012) Nanocapsulated Curcumin: Oral Chemopreventive Formulation against Diethylnitrosamine Induced Hepatocellular Carcinoma in Rat. Chemico-Biological Interactions, 195, 206-214.
http://dx.doi.org/10.1016/j.cbi.2011.12.004
 
[10]Chen, Y., Wu, Q., Zhang, Z., Yuan, L., Liu, X. and Zhou, L. (2012) Preparation of Curcumin-Loaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics. Molecules, 17, 5972-5987.
http://dx.doi.org/10.3390/molecules17055972
 
[11]Dhule, S.S., Penfornis, P., Frazier, T., Walker, R., Feldman, J., Tan, G., He, J., Alb, A., John, V., EngSca, D. and Pochampally, R. (2012) Curcumin-Loaded γ-Cyclodextrin Liposomal Nanoparticles as Delivery Vehicles for Osteosarcoma. Nanomedicine: Nanotechnology, Biology, and Medicine, 8, 440-451.
 
[12]Li, L., Braiteh, F.S. and Kurzrock, R. (2005) Liposome-Encapsulated Curcumin: In Vitro and In Vivo Effects on Proliferation, Apoptosis, Signaling, and Angiogenesis. Cancer, 104, 1323-1331.
 
[13]Huang, M.T., Lu, Y.P., Chang, R.L., Fisher, C., Manchand, P.S., Newmark, H.L. and Conney, A.H. (1995) Effects of Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin and Tetrahydrocurcumin on 12-0-Tetradecanoylphorbol-13Acetateinduced Tumor Promotion. Carcinogenesis, 16, 2493-2497.
 
[14]Raheem, F.W. and Raheem, M.A. (2008) Gynecological Cancer Incidence in a Hospital Population in Saudi Arabia: The Effect of Foreign Immigration over Two Decades. Journal of Obstetrics and Gynaecology Research, 34, 538-542.
http://dx.doi.org/10.1111/j.1447-0756.2008.00735.x
 
[15]Ganta, S. and Amiji, M. (2009) Coadministration of Paclitaxel and Curcumin in Nanoemulsion Formulations to Overcome Multidrug Resistance in Tumor Cells. Molecular Pharmaceutics, 6, 928-939.
http://dx.doi.org/10.1021/mp800240j
 
[16]Kumar, S.S.D., Surianarayanan, M., Vijayaraghavan, R., Mandal, A.B., MacFarlane, D.R. and Veena, M.S. (2014) Curcumin Loaded Poly(2-hydroxyethyl methacrylate) Nanoparticles from Gelled Ionic Liquid—In Vitro Cytotoxicity and Anti-Cancer Activity in SKOV-3 Cells. European Journal of Pharmaceutical Sciences, 51, 34-44.
http://dx.doi.org/10.1016/j.ejps.2013.08.036
 
[17]Crist, K.A., Zhang, Z., You, M., Gunning, W.T., Conran, P.B., Steele, V.E. and Lubet, R.A. (2005) Characterization of Rat Ovarian Adenocarcinomas Developed in Response to Direct Instillation of 7,12-Dimethylbenz[α]Anthracene (DMBA) Coated Suture. Carcinogenesis, 26, 951-957.
http://dx.doi.org/10.1093/carcin/bgi039
 
[18]Sait, K. (2011) Conservative Treatment of Ovarian Cancer Safety, Ovarian Function Preservation, Reproductive Ability, and Emotional Attitude of the Patients in Saudi Arabia. Saudi Medical Journal, 32, 913-918.
 
[19]Wahl, H.L.T., Griffith, K., Choi, M. and Liu, J. (2007) Curcumin Enhances Apo2L/TRAIL-Induced Apoptosis in Chemoresistant Ovarian Cancer Cells. Gynecologic Oncology, 105, 104-112.
http://dx.doi.org/10.1016/j.ygyno.2006.10.050
 
[20]Yunos, N.M., Beale, P., Yu, J.Q. and Hug, F. (2011) Synergism from Sequenced Combinations of Curcumin and Epigallocatechin-3-gallate with Cisplatin in the Killing of Human Ovarian Cancer Cells. Anticancer Research, 31, 11311140.
 
[21]Selvendiran, K., Ahmed, S., Dayton, A., Kuppusamy, M.L., Rivera, B.K., Kálai, T., Hideg, K. and Kuppusamy, P. (2011) HO-3867, A Curcumin Analog, Sensitizes Cisplatin-Resistant Ovarian Carcinoma, Leading to Therapeutic Synergy through STAT3 Inhibition. Cancer Biology and Therapy, 12, 837-845.
http://dx.doi.org/10.4161/cbt.12.9.17713
 
[22]AL-Badawi, I.A., Brasher, P.M., Ghatage, P., Nation, J.G., Schepansky, A. and Stuart, G.C. (2002) Postoperative Chemotherapy in Advanced Ovarian Granulosa Cell Tumors. International Journal of Gynecological Cancer, 12, 119123.
http://dx.doi.org/10.1046/j.1525-1438.2002.01067.x
 
[23]Stirling, G., Khalil, A.M., Nada, G.N., Saad, A.A. and Raheem, M.A. (1979) Malignant Neoplasms in Saudi Arabia. Cancer, 44, 1543-1548.
http://dx.doi.org/10.1002/1097-0142(197910)44:4<1543::AID-CNCR2820440456>3.0.CO;2-N
 
[24]Al-Badawi, I.A., AlSubhi, J., Salem, H., Abduljabbar, A., Balaraj, K. and Munkarah, A. (2010) Laparoscopic Ovarian Transposition before Pelvic Irradiation. International Journal of Gynecological Cancer, 20, 1082-1086.
http://dx.doi.org/10.1111/IGC.0b013e3181e2ace5
 
[25]Kakkar, V., Singh, S., Singla, D. and Kaur, I.P. (2011) Exploring Solid Lipid Nanoparticles to Enhance the Oral Bioavailability of Curcumin. Molecular Nutrition & Food Research, 55, 495-503.
http://dx.doi.org/10.1002/mnfr.201000310
 
[26]Al-Badawi, I.A., Munkarah, A.R., Tulbah, A., Babic, I.I., Al Husaini, H. and Ahmad, S. (2013) A Detailed Study of Patients and Tumor Characteristics of Epithelial Ovarian Cancer in Saudi Women. International Journal of Gynecological Cancer, 23, 456-460.
http://dx.doi.org/10.1097/IGC.0b013e318284aafe
 
[27]Tamaddonfard, E., Hamzeh-Gooshchi, F. and Hamzeh-Gooshchi, N. (2010) Effect of Curcumin on Morphine-Induced Antinociception in Acute Corneal Pain in Rats. International Journal of Veterinary Research, 4, 127-131.
 
[28]LoTempio, M.M., Veena, M.S., Steele, H.L., Ramamurthy, B., Ramalingam, T.S., Cohen, A.N., Chakrabarti, R., Srivatsan, E.S. and Wang, M.B. (2005) Curcumin Suppresses Growth of Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research, 11, 6994-7002.
http://dx.doi.org/10.1158/1078-0432.CCR-05-0301                                                            eww150107lx
 
标签：

评论

发表评论

此博客中的热门博文

A Comparison of Methods Used to Determine the Oleic/Linoleic Acid Ratio in Cultivated Peanut (Arachis hypogaea L.)

Cultivated peanut ( Arachis hypogaea L.) is an important oil and food crop. It is also a cheap source of protein, a good source of essential vitamins and minerals, and a component of many food products. The fatty acid composition of peanuts has become increasingly important with the realization that oleic acid content significantly affects the development of rancidity. And oil content of peanuts significantly affects flavor and shelf-life. Early generation screening of breeding lines for high oleic acid content greatly increases the efficiency of developing new peanut varieties. The objective of this study was to compare the accuracy of methods used to classify individual peanut seed as high oleic or not high oleic. Three hundred and seventy-four (374) seeds, spanning twenty-three (23) genotypes varying in oil composition (i.e. high oleic (H) or normal/not high oleic (NH) inclusive of all four peanut market-types (runner, Spanish, Valencia and Virginia), were individually tested ...
发表评论
阅读全文

Location Optimization of a Coal Power Plant to Balance Costs against Plant’s Emission Exposure

Fuel and its delivery cost comprise the biggest expense in coal power plant operations. Delivery of electricity from generation to consumers requires investment in power lines and transmission grids. Placing a coal power plant or multiple power plants near dense population centers can lower transmission costs. If a coalmine is nearby, transportation costs can also be reduced. However, emissions from coal plants play a key role in worsening health crises in many countries. And coal upon combustion produces CO 2 , SO 2 , NO x , CO, Metallic and Particle Matter (PM10 & PM2.5). The presence of these chemical compounds in the atmosphere in close vicinity to humans, livestock, and agriculture carries detrimental health consequences. The goal of the research was to develop a methodology to minimize the public’s exposure to harmful emissions from coal power plants while maintaining minimal operational costs related to electric distribution losses and coal logistics. The objective was...
发表评论
阅读全文

Evaluation of the Safety and Efficacy of Continuous Use of a Home-Use High-Frequency Facial Treatment Appliance

At present, many home-use beauty devices are available in the market. In particular, many products developed for facial treatment use light, e.g., a flash lamp or a light-emitting diode (LED). In this study, the safety of 4 weeks’ continuous use of NEWA TM , a high-frequency facial treatment appliance, every alternate day at home was verified, and its efficacy was evaluated in Japanese individuals with healthy skin aged 30 years or older who complained of sagging of the facial skin.  Transepidermal water loss (TEWL), melanin levels, erythema levels, sebum secretion levels, skin color changes and wrinkle improvement in the facial skin were measured before the appliance began to be used (study baseline), at 2 and 4 weeks after it had begun to be used, and at 2 weeks after completion of the 4-week treatment period (6 weeks from the study baseline). In addition, data obtained by subjective evaluation by the subjects themselves on a visual analog scale (VAS) were also analyzed. Fur...
发表评论
阅读全文