跳至主要内容

Risk Factors for Hemoptysis in Pulmonary Tuberculosis Patients from Southern China: A Retrospective Study

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52104#.VIVGQWfHRK0

Clinical characteristics of tuberculosis (TB) patients from southern China with pulmonary tuberculosis hemoptysis (PTH) were analyzed retrospectively in order to improve the diagnosis of TB, reduce mortality and prevent the transmission of TB. A total of 1227 cases of pulmonary TB patients hospitalized in the Third Affiliated Hospital of Sun Yat-sen University and Guangzhou Chest Hospital from January to December of 2011 were analyzed retrospectively. 1) The male/female ratio of the 1227 tuberculosis cases was 2.15:1. There were 403 cases (32.8%) of PTH with a male/ female ratio of 3.03:1. 2) The ratio of patients with PTH to those with TB was designated as Rh. The Rh in the male group (36.2%, 303 cases) was higher than that in the female group (25.6%, 100 cases, risk ratio (RR) = 1.41, P ≤ 0.001). 3) The Rh in the elderly group (≥60 years old, 20.3%, 56 cases) was lower than that in the younger patients group (20 - 39 years old, 45.4%, 189 cases, RR = 2.51, P ≤ 0.001). 4) The Rh in initial treatment group (29.6%, 296 cases) was lower than that in the retreatment group (46.9%, 107 cases, RR = 1.58, P ≤ 0.001). 5) The Rh in sputum-positive TB patients (44.5%, 297 cases) was significantly higher than that in the smear-negative TB patients (18.9%, 106 cases, RR = 2.35, P ≤ 0.001). 6) The Rh of patients with lung lesions range < 3 lung fields (31.7%, 105 cases) was not significantly different with that of patients with lung lesions range ≥ 3 lung fields (33.3%, 298 cases, RR = 1.05, P = 0.96 > 0.05). 7) The Rh of patients with cavities (51.8%, 309 cases) was higher than that of patients without cavities (14.9%, 94 cases, RR = 3.48, P ≤ 0.001). Male, young, retreated, sputum-positive TB patients and those with cavitary TB were more predisposed to PTH in southern China. TB patients with such characteristics should be sensitized and accorded good care.
Cite this paper
Tan, S. , Sun, D. , Zhang, T. , Li, Y. , Cao, Y. , Njire, M. , Wang, C. and Zhang, T. (2014) Risk Factors for Hemoptysis in Pulmonary Tuberculosis Patients from Southern China: A Retrospective Study. Journal of Tuberculosis Research, 2, 173-180. doi: 10.4236/jtr.2014.24022. 
 

[1] Pianosi, P. and Al-sadoon, H. (1996) Hemoptysis in Children. Pediatrics in Review, 17, 344-348.
[2] Jean-Baptiste, E. (2000) Clinical Assessment and Management of Massive Hemoptysis. Critical Care Medicine, 28, 1642-1647.
[3] Reechaipichitkul, W. and Latong, S. (2005) Etiology and Treatment Outcomes of Massive Hemoptysis. The Southeast Asian Journal of Tropical Medicine and Public Health, 36, 474-480.
[4] Van-Kralingen, K., Van Kralingen-Heijboer, A., Zimmerman, M. and Postmus, P. (1995) Management of Hemoptysis in a Third World City Hospital: A Retrospective Study. Tubercle and Lung Disease, 76, 344-348.
[5] Porzezińska, M., Gorzewska, A., Drozdowski, J., Sulzycka, M. and Slomiński, J. (2005) Assessment of Hemoptysis Etiology among Patients Hospitalized in Pneumonology Departament of Medical University of Gdansk in the Years 1998-2002. Polskie Archiwum Medycyny Wewnetrznej, 114, 658-663.
[6] Tsoumakidou, M., Chrysofakis, G., Tsiligianni, I., Maltezakis, G., Siafakas, N.M. and Tzanakis, N. (2006) A Prospective Analysis of 184 Hemoptysis Cases—Diagnostic Impact of Chest X-Ray, Computed Tomography, Bronchoscopy. Respiration, 73, 808-814.
[7] Soares, P.F., Teixeira, N., Coelho, F. and Damas, C. (2011) Hemoptysis—Etiology, Evaluation and Treatment in a University Hospital. Revista Portuguesa de Pneumologia (English Edition), 17, 7-14.
[8] Uzun, O., Atasoy, Y., Findik, S., Atici, A.G. and Erkan, L. (201) A Prospective Evaluation of Hemoptysis Cases in a Tertiary Referral Hospital. The Clinical Respiratory Journal, 4, 131-138.
[9] National Technical Steering Group of the Epidemiological Sampling Survey for Tuberculosis Office of the Nationwide Epidemiological Sampling Survey for Tuberculosis (2002) Report on Nationwide Random Survey for the Epidemiology of Tuberculosis in 2000. The Journal of the Chinese Antituberculosis Association, 24, 65-66. http://dx.doi.org/10.3969/j.issn.1000-6621.2002.02.001
[10] Hirshberg, B., Biran, I., Glazer, M. and Kramer, M.R. (1997) Hemoptysis: Etiology, Evaluation, and Outcome in a Tertiary Referral Hospital. Chest Journal, 112, 440-444.
[11] Tuberculosis Csf. (2001) Tuberculosis Diagnosis and Treatment Guidelines. Chinese Journal of Tuberculosis and Respiratory Diseases, 24, 70-74.
[12] Association, C.M. (2005) Clinical Practice Guidelines: Tuberculosis Volume. People’s Medical Publishing House, Beijing, 110 p.
[13] Uplekar, M., Rangan, S., Weiss, M., Ogden, J., Borgdorff, M. and Hudelson, P. (2001) Attention to Gender Issues in Tuberculosis Control. International Journal of Tuberculosis and Lung Disease, 5, 220-224.
[14] Kolappan, C. and Gopi, P. (2002) Tobacco Smoking and Pulmonary Tuberculosis. Thorax, 57, 964-966. http://dx.doi.org/10.1136/thorax.57.11.964
[15] Bates, M.N., Khalakdina, A., Pai, M., Chang, L., Lessa, F. and Smith, K.R. (2007) Risk of Tuberculosis from Exposure to Tobacco Smoke: A Systematic Review and Meta-Analysis. Archives of Internal Medicine, 167, 335-342. http://dx.doi.org/10.1001/archinte.167.4.335
[16] Li, Y. and Gu, Z. (2010) Clinical Analysis of 90 Cases of Pulmonary Tuberculosis Hemoptysis. China Medical Herald, 5, 105.
[17] Achkar, J. and Joseph, G. (2012) Independent Association of Younger Age with Hemoptysis in Adults with Pulmonary Tuberculosis. International Journal of Tuberculosis and Lung Disease, 16, 897-902.
http://dx.doi.org/10.5588/ijtld.11.0758
[18] Pérez-Guzmán, C., Vargas, M.H., Torres-Cruz, A. and Villarreal-Velarde, H. (1999) Does Aging Modify Pulmonary Tuberculosis? A Meta-Analytical Review. Chest Journal, 116, 961-967.
http://dx.doi.org/10.1378/chest.116.4.961
[19] Dorshkind, K. and Swain, S. (2009) Age-Associated Declines in Immune System Development and Function: Causes, Consequences, and Reversal. Current Opinion in Immunology, 21, 404-407.
http://dx.doi.org/10.1016/j.coi.2009.07.001
[20] Yuan, Y.G.W. (2012) Diagnosis and Treatment of 167 Cases of Patients with Hemoptysis Analysis. Clinical Pulmonary Medicine, 11, 2055-2055.
[21] Irodi, A. and Keshava, S. (2009) Rasmussen’s Aneurysm―Undue Importance to an Uncommon Entity? British Journal of Radiology, 82, 698. http://dx.doi.org/10.1259/bjr/87990037
[22] Zellwegera, C.C., Maillarda, J.O., Christend, G. and Auberta, J.D. (2004) Successful Embolization of Rasmussen’s Aneurysm for Severe Haemoptysis. Swiss Medical Weekly, 134, 47-48.
[23] Wu, X.M., Lai, Q., Chen, Y.F., Ren, Y.M., Liang, R.G. and Soong, Y.Q. (2008) Relationship between Broncho-Pulmonary Shunt and Massive Hemoptysis (a Report of 62 Cases). China Journal of Modern Medicine, 18, 939-943.
[24] Ozgül, M., Turna, A., Yildiz, P., Ertan, E., Kahraman, S. and Yilmaz, V. (2006) Risk Factors and Recurrence Patterns in 203 Patients with Hemoptysis. Türk Tüberküloz ve Toraks Dernegi, 54, 243-248.
[25] Goble, M., Iseman, M.D., Madsen, L.A., Waite, D., Ackerson, L. and Horsburgh Jr., C.R. (1993) Treatment of 171 Patients with Pulmonary Tuberculosis Resistant to Isoniazid and Rifampin. New England Journal of Medicine, 328, 527- 532. http://dx.doi.org/10.1056/NEJM199302253280802
[26] Ma, Y. and Panyu, X. (2006) Tuberculosis. People’s Health Publishing House, Beijing, 71.
[27] Sopko, D.R. and Smith, T.P. (2011) Bronchial Artery Embolization for Hemoptysis. Seminars in Interventional Radiology, 28, 48-62. http://dx.doi.org/10.1055/s-0031-1273940                   eww141208lx
标签：

评论

发表评论

此博客中的热门博文