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Is It Possible to Predict the Outcome of IVF Treatment in Poor Response Patients?

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http://www.scirp.org/journal/PaperInformation.aspx?PaperID=49264#.VJD5cMnQrzE

Poor ovarian response (POR)—retrieval of 3 or fewer eggs, is a challenging issue in IVF. A retrospective study included POR women who underwent 386 IVF cycles. The data were classified in four groups according to women’s age (years) during the treatment cycle: 1) 20 - 34 (n = 133), 2) 35 - 39 (n = 133), 3) 40 - 42 (n = 78), 4) 43 - 47 y (n = 42), and correlated with the characteristics of the population. The clinical pregnancy rates for groups 1, 2, 3, and 4 were: 23.3%, 12%, 2.6%, 4.8%, respectively. It was found to be significantly higher (p < 0.001) comparing group 1 with group 3 patients. The “take home baby” rate was much lower (p < 0.001) in group 3; there were no deliveries in group 4. Delivery rates for groups 1, 2, 3, and 4 were: 19.5%, 10.5%, 1.3% and 0%, respectively. Intraabdominal adhesions were more common (p = 0.005) as the cause of infertility in group 3 women compared to groups 2 and 1: 24.4% compared with 9% and 9.8%, respectively. According to multivariate regression analysis, the parameters that negatively reflect on the pregnancy rate in POR women are intraabdominal adhesions, POR in the past, and increased age. We suggest encouraging young POR patients to pursue IVF treatments since the “take home baby” rates are reasonably good.
Cite this paper
Uretzky, A. , Harlev, A. , Man, L. , Lunenfeld, E. , Har-Vardi, I. , Friger, M. and Levitas, E. (2014) Is It Possible to Predict the Outcome of IVF Treatment in Poor Response Patients?. Open Journal of Obstetrics and Gynecology, 4, 703-709. doi: 10.4236/ojog.2014.412098. 
 

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