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Immunological Responses against Different Lineages of Influenza B Antigen in School Children during Two Consecutive Seasons

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http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52499#.VJohBcCAM4

While Influenza B viruses currently circulating worldwide are of two distinct evolutionary hemagglutinin lineages, current trivalent inactivated influenza virus vaccines (TIV) contain only a single component. Single doses of TIV containing B antigen of B/Florida/4/2006 (Yamagata-like) or B/Brisbane/60/2008 (Victoria-like) were administered during 2008/2009 and 2009/2010 influenza seasons, respectively. The objective of this study was to evaluate the immunological response against different lineages of B antigens in school-aged children. A non-randomized sero-epidemiological study was conducted and the immunogenicity responses based on sero-protection rate and geometric mean titre ratio (GMTR) of hemagglutination inhibition (HI) antibodies were measured before and after immunization as well as post-influenza season. Our results suggested that school-aged children under the age of 9 years receiving TIV vaccination induced and retained higher level of sero-protection rate (66.7% and 69% for the 2008-09 and 2009-10 season, respectively) to the homologous lineage than the heterologous lineage post-vaccination (19.4% and 27.6% for the 2008-09 and 2009-10 season, respectively). The need for the quadrivalent TIV by including both lineages of influenza B viruses is recommended in this study, particularly for children under the age of 9 years.
Cite this paper
Chao, D. , Cheng, K. , Liao, Y. , Liu, M. , Hsieh, Y. , Li, T. , Wu, T. and Chen, C. (2014) Immunological Responses against Different Lineages of Influenza B Antigen in School Children during Two Consecutive Seasons. Health, 6, 2837-2847. doi: 10.4236/health.2014.621322.
 

[1] Cox, N.J. and Subbarao, K. (2005) Global Epidemiology of Influenza: Past and Present. Annual Review of Medicine, 51, 407-421.
http://dx.doi.org/10.1146/annurev.med.51.1.407
[2] Boni, M.F. (2008) Vaccination and Antigenic Drift in Influenza. Vaccine, 26, C8-C14.
http://dx.doi.org/10.1016/j.vaccine.2008.04.011
[3] Couch, R.B. (2000) Prevention and Treatment of Influenza. New England Journal of Medicine, 343, 1778-1787.
http://dx.doi.org/10.1056/NEJM200012143432407
[4] Carrat, F. and Flahault, A. (2007) Influenza Vaccine: The Challenge of Antigenic Drift. Vaccine, 25, 6852-6862.
http://dx.doi.org/10.1016/j.vaccine.2007.07.027
[5] Shaw, M., et al. (2002) Reappearance and Global Spread of Variants of Influenza B/Victoria/2/87 Lineage Viruses in the 2000-2001 and 2001-2002 Seasons. Virology, 303, 1-8.
http://dx.doi.org/10.1006/viro.2002.1719
[6] Chi, X., et al. (2005) Detection and Characterization of New Influenza B Virus Variants in 2002. Journal of Clinical Microbiology, 43, 2345-2349.
http://dx.doi.org/10.1128/JCM.43.5.2345-2349.2005
[7] Puzelli, S., et al. (2004) Changes in the Hemagglutinins and Neuraminidases of Human Influenza B Viruses Isolated in Italy during the 2001-02, 2002-03, and 2003-04 Seasons. Journal of Medical Virology, 74, 629-640.
http://dx.doi.org/10.1002/jmv.20225
[8] Lin, J., et al. (2007) Characterization of the Epidemic Influenza B Viruses Isolated during 2004-2005 Season in Taiwan. Virus Research, 124, 204-211.
http://dx.doi.org/10.1016/j.virusres.2006.11.005
[9] Jian, J., et al. (2008) Genetic and Epidemiological Analysis of Influenza Virus Epidemics in Taiwan during 2003 to 2006. Journal of Clinical Microbiology, 46, 1426-1434.
http://dx.doi.org/10.1128/JCM.01560-07
[10] Shih, S., et al. (2005) Laboratory-Based Surveillance and Molecular Epidemiology of Influenza Virus in Taiwan. Journal of Clinical Microbiology, 43, 1651-1661.
http://dx.doi.org/10.1128/JCM.43.4.1651-1661.2005
[11] Jian, J.-W., Lai, C.-T., Kuo, C.-Y., Kuo, S.H.S., Hsu, L.-C., Chen, P.-J., et al. (2008) Genetic Analysis and Evaluation of the Reassortment of Influenza B Viruses Isolated in Taiwan during the 2004-2005 and 2006-2007 Epidemics. Virus Research, 131, 243-249.
http://dx.doi.org/10.1016/j.virusres.2007.09.014
[12] Tsai, H.-P., Wang, H.-C., Kiang, D., Huang, S.-W., Kuo, P.-H., Liu, C.-C., et al. (2006) Increasing Appearance of Reassortant Influenza B Virus in Taiwan from 2002 to 2005. Journal of Clinical Microbiology, 44, 2705-2713.
http://dx.doi.org/10.1128/JCM.02694-05
[13] Belshe, R.B. (2010) The Need for Quadrivalent Vaccine against Seasonal Influenza. Vaccine, 28, D45-D53.
http://dx.doi.org/10.1016/j.vaccine.2010.08.028
[14] Kanegae, Y., Sugita, S., Endo, A., Ishida, M., Senya, S., Osako, K., et al. (1990) Evolutionary Pattern of the Hemagglutinin Gene of Influenza B Viruses Isolated in Japan: Cocirculating Lineages in the Same Epidemic Season. Journal of Virology, 64, 2860-2865.
[15] Rota, P.A., Wallis, T.R., Harmon, M.W., Rota, J.S., Kendal, A.P. and Nerome, K. (1990) Cocirculation of Two Distinct Evolutionary Lineages of Influenza Type B Virus since 1983. Virology, 175, 59-68.
http://dx.doi.org/10.1016/0042-6822(90)90186-U
[16] Levandowski, R.A., Gross, P.A., Weksler, M., Staton, E., Williams, M.S. and Bonelli, J. (1991) Cross-Reactive Antibodies Induced by a Monovalent Influenza B Virus Vaccine. Journal of Clinical Microbiology, 29, 1530-1532.
[17] Fiore, A.E., Shay, D.K., Broder, K., Iskander, J.K., Uyeki, T.M., Mootrey, G., et al. (2008) Prevention and Control of Influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008. Morbidity and Mortality Weekly Report Recommendations and Report, 57, 1-60.
[18] Hurwitz, E.S., Haber, M., Chang, A., Shope, T., Teo, S., Ginsberg, M., et al. (2000) Effectiveness of Influenza Vaccination of Day Care Children in Reducing Influenza-Related Morbidity among Household Contacts. The Journal of the American Medical Association, 284, 1677-1682.
http://dx.doi.org/10.1001/jama.284.13.1677
[19] Reichert, T.A., Sugaya, N., Fedson, D.S., Glezen, W.P., Simonsen, L. and Tashiro, M. (2001) The Japanese Experience with Vaccinating Schoolchildren against Influenza. New England Journal of Medicine, 344, 889-896.
http://dx.doi.org/10.1056/NEJM200103223441204
[20] Davis, M.M., King Jr., J.C., Moag, L., Cummings, G. and Magder, L.S. (2008) Countywide School-Based Influenza Immunization: Direct and Indirect Impact on Student Absenteeism. Pediatrics, 122, e260-e265.
http://dx.doi.org/10.1542/peds.2007-2963
[21] Su, W.-J., Shao, P.-L., Liu, M.-T., Liu, D.-P., Huang, K.-C., Chang, L.-Y., et al. (2010) Low Seroprotection against Preseasonal Influenza Local Strains in Children Might Predict the Upcoming Epidemic Influenza Strains. Clinical Infectious Diseases, 51, 171-176.
http://dx.doi.org/10.1086/653532
[22] Bodewes, R., de Mutsert, G., van der Klis, F.R.M., Ventresca, M., Wilks, S., Smith, D.J., et al. (2011) Prevalence of Antibodies against Seasonal Influenza A and B Viruses in Children in Netherlands. Clinical Vaccine and Immunology, 18, 469-476.
http://dx.doi.org/10.1128/CVI.00396-10
[23] Rowe, T., Abernathy, R.A., Hu-Primmer, J., Thompson, W.W., Lu, X.H., Lim, W., et al. (1999) Detection of Antibody to Avian Influenza A (H5N1) Virus in Human Serum by Using a Combination of Serologic Assays. Journal of Clinical Microbiology, 37, 937-943.
[24] World Health Organization (2002) WHO Manual on Animal Influenza Diagnosis and Surveillance. WHO/CDS/CSR/ NCS/20025.
[25] Yang, J.-R., Lin, C.-H., Chen, C.-J., Liu, J.-L., Huang, Y.-P., Kuo, C.-Y., et al. (2010) A New Antigenic Variant of Human Influenza A (H3N2) Virus Isolated from Airport and Community Surveillance in Taiwan in Early 2009. Virus Research, 151, 33-38.
http://dx.doi.org/10.1016/j.virusres.2010.03.011
[26] Yang, J.-R., Lo, J., Liu, J.-L., Lin, C.-H., Ho, Y.-L., Chen, C.-J., et al. (2009) Rapid SYBR Green I and Modified Probe Real-Time Reverse Transcription-PCR Assays Identify Influenza H1N1 Viruses and Distinguish between Pandemic and Seasonal Strains. Journal of Clinical Microbiology, 47, 3714-3716.
http://dx.doi.org/10.1128/JCM.01646-09
[27] McCullers, J.A., Saito, T. and Iverson, A.R. (2004) Multiple Genotypes of Influenza B Virus Circulated between 1979 and 2003. Journal of Virology, 78, 12817-12828.
http://dx.doi.org/10.1128/JVI.78.23.12817-12828.2004
[28] Hite, L.K., Glezen, W.P., Demmler, G.J. and Munoz, F.M. (2007) Medically Attended Pediatric Influenza during the Resurgence of the Victoria Lineage of Influenza B Virus. International Journal of Infectious Diseases, 11, 40-47.
http://dx.doi.org/10.1016/j.ijid.2005.10.008
[29] Rota, P.A., Hemphill, M.L., Whistler, T., Regnery, H.L. and Kendal, A.P. (1992) Antigenic and Genetic Characterization of the Haemagglutinins of Recent Cocirculating Strains of Influenza B Virus. Journal of General Virology, 73, 2737-2742.
http://dx.doi.org/10.1099/0022-1317-73-10-2737
[30] Robertson, J.S., Bootman, J.S., Nicolson, C., Major, D., Robertson, E.W. and Wood, J.M. (1990) The Hemagglutinin of Influenza B Virus Present in Clinical Material Is a Single Species Identical to That of Mammalian Cell-Grown Virus. Virology, 179, 35-40.
http://dx.doi.org/10.1016/0042-6822(90)90270-2
[31] Kendal, A.P. and Cate, T.R. (1983) Increased Sensitivity and Reduced Specificity of Hemagglutination Inhibition Tests with Ether-Treated Influenza B/Singapore/222/79. Journal of Clinical Microbiology, 18, 930-934.
[32] Monto, A.S. and Maassab, H.F. (1981) Ether Treatment of Type B Influenza Virus Antigen for the Hemagglutination Inhibition Test. Journal of Clinical Microbiology, 13, 54-47.
[33] Frank, A.L., Taber, L.H., Glezen, W.P., Geyer, E.A., McIlwain, S. and Paredes, A. (1983) Influenza B Virus Infections in the Community and the Family: The Epidemics of 1976-1977 and 1979-1980 in Houston, Texas. American Journal of Epidemiology, 118, 313-325.
[34] Hannoun, C., Megas, F. and Piercy, J. (2004) Immunogenicity and Protective Efficacy of Influenza Vaccination. Virus Research, 103, 133-138.
http://dx.doi.org/10.1016/j.virusres.2004.02.025
[35] Levandowski, R.A., Regnery, H.L., Staton, E., Burgess, B.G., Williams, M.S. and Groothuis, J.R. (1991) Antibody Responses to Influenza B Viruses in Immunologically Unprimed Children. Pediatrics, 88, 1031-1036.
[36] Englund, J.A., Walter, E.B., Gbadebo, A., Monto, A.S., Zhu, Y. and Neuzil, K.M. (2006) Immunization with Trivalent Inactivated Influenza Vaccine in Partially Immunized Toddlers. Pediatrics, 118, e579-e585.
http://dx.doi.org/10.1542/peds.2006-0201
[37] Reichert, T. (2002) The Japanese Program of Vaccination of Schoolchildren against Influenza: Implications for Control of the Disease. Seminars in Pediatric Infectious Diseases, 13, 104-111.
http://dx.doi.org/10.1053/spid.2002.122997
[38] King, J.C., Stoddard, J.J., Gaglani, M.J., Moore, K.A., Magder, L., McClure, E., et al. (2006) Effectiveness of School-Based Influenza Vaccination. New England Journal of Medicine, 355, 2523-2532.
http://dx.doi.org/10.1056/NEJMoa055414
[39] Li, W.-C., Shih, S.-R., Huang, Y.-C., Chen, G.-W., Chang, S.-C., Hsiao, M.-J., et al. (2008) Clinical and Genetic Characterization of Severe Influenza B-Associated Diseases during an Outbreak in Taiwan. Journal of Clinical Virology, 42, 45-51.
http://dx.doi.org/10.1016/j.jcv.2007.11.026
[40] Thompson, W.W., Shay, D.K., Weintraub, E., Brammer, L., Cox, N., Anderson, L.J. and Fukuda, K. (2003) Mortality Associated with Influenza and Respiratory Syncytial Virus in the United States. The Journal of the American Medical Association, 289, 179-186.
http://dx.doi.org/10.1001/jama.289.2.179
[41] Glezen, W.P., Couch, R.B., Taber, L.H., Paredes, A., Allison, J.E., Frank, A.L. and Aldridge, C. (1980) Epidemiologic Observations of Influenza B Virus Infections in Houston, Texas, 1976-1977. American Journal of Epidemiology, 111, 13-22.                     eww141224lx
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