跳至主要内容

Gender Does Not Have a Potential Predictive Value for the Presence of Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinoma

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52372#.VJODucCAM4

Background: Previous studies reported that non-small cell carcinoma patients characterized by female gender, never-smoking status and adenocarcinoma histology were more likely to harbor epidermal growth factor receptor (EGFR) mutations. However, some studies failed to find the relationship between EGFR mutation and gender. Methods: One hundred and eighty-four consecutive patients (90 men and 94 women) of resected lung adenocarcinoma were studied retrospectively. Since the smoking rate is significantly higher in men, we assumed that gender difference might be a seeming factor affected by smoking. Therefore we subdivided the patients into 2 groups: never- and ever-smokers. Results: The number of ever-smokers was 94.44% in men, whereas 8.51% in women. EGFR mutation was positive in 48.9%. For overall patients, EGFR mutation status was associated with gender, pStage, pT status, lepidic dominant histologic subtype, pure/mixed groundglass opacity (GGO) on computed tomography (CT) and smoking status. However, in ever-smokers, EGFR mutation status was associated with lepidic histologic subtype and GGO on CT, but not others including gender. Similar results were also found in never-smokers, and gender was not also related to EGFR mutation in never smokers. Conclusion: The EGFR mutational frequency among men and women was not significantly different when lung adenocarcinoma patients were stratified into never- and ever-smokers.
 
Cite this paper
Tomita, M. , Ayabe, T. , Chosa, E. , Kawagoe, K. and Nakamura, K. (2014) Gender Does Not Have a Potential Predictive Value for the Presence of Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinoma. Advances in Lung Cancer, 3, 82-87. doi: 10.4236/alc.2014.34012. 
 

[1] Olayioye, M.A., Neve, R.M., Lane, H.A. and Hynes, N.E. (2000) The ErbB Signaling Network: Receptor Heterodimerization in Development and Cancer. The EMBO Journal, 19, 3159-3167.
http://dx.doi.org/10.1093/emboj/19.13.3159
[2] Pinkas-Kramarski, R., Soussan, L., Waterman, H., Levkowitz, G., Alroy, I., Klapper, L., Lavi, S., Seger, R., Ratzkin, B.J., Sela, M. and Yarden, Y. (1996) Diversification of Neu Differentiation Factor and Epidermal Growth Factor Signaling by Combinatorial Receptor Interactions. The EMBO Journal, 15, 2452-2467.
[3] Lynch, T.J., Bell, D.W., Sordella, R., Gurubhagavatula, S., Okimoto, R.A., Brannigan, B.W., Harris, P.L., Haserlat, S.M., Supko, J.G., Haluska, F.G., Louis, D.N., Christiani, D.C., Settleman, J. and Haber, D.A. (2004) Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib. The New England Journal of Medicine, 350, 2129-2139. http://dx.doi.org/10.1056/NEJMoa040938
[4] Kosaka, T., Yatabe, Y., Endoh, H., Kuwano, H., Takahashi, T. and Mitsudomi, T. (2004) Mutations of the Epidermal growth Factor Receptor Gene in Lung Cancer: Biological and Clinical Implications. Cancer Research, 64, 8919-8923. http://dx.doi.org/10.1158/0008-5472.CAN-04-2818
[5] Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I.I., Fong, K.M., Lee, H., Toyooka, S., Shimizu, N., Fujisawa, T., Feng, Z., Roth, J.A., Herz, J., Minna, J.D. and Gazdar, A.F. (2005) Clinical and Biological Features Associated with Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers. Journal of the National Cancer Institute, 97, 339-346. http://dx.doi.org/10.1093/jnci/dji055
[6] Mitsudomi, T., Kosaka, T. and Yatabe, Y. (2006) Biological and Clinical Implications of EGFR Mutations in Lung Cancer. International Journal of Clinical Oncology, 11, 190-198. http://dx.doi.org/10.1007/s10147-006-0583-4
[7] D’Angelo, S.P., Pietanza, M.C., Johnson, M.L., Riely, G.J., Miller, V.A., Sima, C.S., Zakowski, M.F., Rusch, V.W., Ladanyi, M. and Kris, M.G. (2011) Incidence of EGFR Exon 19 Deletions and L858R in Tumor Specimens from Men and Cigarette Smokers with Lung Adenocarcinomas. Journal of Clinical Oncology, 29, 2066-2070. http://dx.doi.org/10.1200/JCO.2010.32.6181
[8] Hsiao, S.H., Lin, S.E., Chou, Y.T., Wang, J.L., Chung, C.L., Yu, M.C., Fang, C.L., Lee, H.L., Chiang, L.L., Liu, H.E. and Wu, C.W. (2014) Histological Subtype and Smoking Status, But Not Gender, Are Associated with Mutations in Non-Small-Cell Lung Cancer. Molecular and Clinical Oncology, 2, 252-258.
[9] Tanaka, T., Matsuoka, M., Sutani, A., Gemma, A., Maemondo, M., Inoue, A., Okinaga, S., Nagashima, M., Oizumi, S., Uematsu, K., Nagai, Y., Moriyama, G., Miyazawa, H., Ikebuchi, K., Morita, S., Kobayashi, K. and Hagiwara, K. (2010) Frequency of and Variables Associated with the EGFR Mutation and Its Subtypes. International Journal of Cancer, 126, 651-655. http://dx.doi.org/10.1002/ijc.24746
[10] Yatabe, Y., Hida, T., Horio, Y., Kosaka, T., Takahashi, T. and Mitsudomi, T. (2006) A Rapid, Sensitive Assay to Detect EGFR Mutation in Small Biopsy Specimens from Lung Cancer. The Journal of Molecular Diagnostics, 8, 335-341. http://dx.doi.org/10.2353/jmoldx.2006.050104
[11] Brinkman, G.L. and Coates Jr., E.O. (1963) The Effect of Bronchitis, Smoking, and Occupation on Ventilation. The American Review of Respiratory Disease, 87, 684-693.
[12] Travis, W.D., Brambilla, E., Noguchi, M., Nicholson, A.G., Geisinger, K.R., Yatabe, Y., Beer, D.G., Powell, C.A., Riely, G.J., Van Schil, P.E., Garg, K., Austin, J.H., Asamura, H., Rusch, V.W., Hirsch, F.R., Scagliotti, G., Mitsudomi, T., Huber, R.M., Ishikawa, Y., Jett, J., Sanchez-Cespedes, M., Sculier, J.P., Takahashi, T., Tsuboi, M., Vansteenkiste, J., Wistuba, I., Yang, P.C., Aberle, D., Brambilla, C., Flieder, D., Franklin, W., Gazdar, A., Gould, M., Hasleton, P., Henderson, D., Johnson, B., Johnson, D., Kerr, K., Kuriyama, K., Lee, J.S., Miller, V.A., Petersen, I., Roggli, V., Rosell, R., Saijo, N., Thunnissen, E., Tsao, M. and Yankelewitz, D. (2011) International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma. Journal of Thoracic Oncology, 6, 244-285. http://dx.doi.org/10.1097/JTO.0b013e318206a221
[13] Lee, H.J., Kim, Y.T., Kang, C.H., Zhao, B., Tan, Y., Schwartz, L.H., Persigehl, T., Jeon, Y.K. and Chung, D.H. (2013) Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinomas: Relationship with CT Characteristics and Histologic Subtypes. Radiology, 268, 254-264.
http://dx.doi.org/10.1148/radiol.13112553
[14] Hsieh, R.K., Lim, K.H., Kuo, H.T., Tzen, C.Y. and Huang, M.J. (2005) Female Sex and Bronchioloalveolar Pathologic Subtype Predict EGFR Mutations in Non-Small Cell Lung Cancer. Chest, 128, 317-321. http://dx.doi.org/10.1378/chest.128.1.317
[15] Yano, M., Sasaki, H., Kobayashi, Y., Yukiue, H., Haneda, H., Suzuki, E., Endo, K., Kawano, O., Hara, M. and Fujii, Y. (2006) Epidermal Growth Factor Receptor Gene Mutation and Computed Tomographic Findings in Peripheral Pulmonary Adenocarcinoma. Journal of Thoracic Oncology, 1, 413-416.
http://dx.doi.org/10.1097/01243894-200606000-00006
[16] Ambrosini-Spaltro, A., Ruiu, A., Seebacher, C., Vattemi, E., Gentile, L., Feil, B., Zaraca, F. and Carella, R. (2014) Impact of the IASLC/ATS/ERS Classification in pN0 Pulmonary Adenocarcinomas: A Study with Radiological-Pathological Comparisons and Survival Analyses. Pathology, Research and Practice, 210, 40-46. http://dx.doi.org/10.1016/j.prp.2013.09.016                                          eww141219lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文