跳至主要内容

Evaluation of Gojiextract and Charcoal as Antioxidant on T-2 Toxin Administration Onliver Male Mice

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52009#.VH5uqmfHRK0

With a view to study the effects of exposure to T-2 toxin and their amelioration by Goji extract or charcoal, male mice were treated with a sublethal dose of T-2 toxin (200 μg/kg B.W) intraperitoneally. T-2 Toxin showed an increase (P ≤ 0.05) in blood of ALT, ALP, Total Lipids, TAS, and TNF. These were decreased by Goji extracts or charcoal, and were improved partially by the two treatments. It is concluded that the treatment of rats with Goji extract or charcoal ameliorated the adverse effects of toxins but the results suggest that Goji extracts may be used as antioxidant and antidote rather than charcoal for T-2 Toxin in mice.
Cite this paper
Al-Sien, A. and Al-Seni, M. (2014) Evaluation of Gojiextract and Charcoal as Antioxidant on T-2 Toxin Administration Onliver Male Mice. Food and Nutrition Sciences, 5, 2124-2129. doi: 10.4236/fns.2014.522225. 
 

[1] Ueno, Y. (1983) Trichothecenes, Chemical, Biological and Toxicological Aspects. Kodansha Ltd. and Elsevier Science Publishers, Amsterdam, 163-170.
[2] Szathmary, C.I., Mirocha, C.J., Polyusik, M. and pathre, S.V. (1976) Identification of Mycotoxins Produced by Species of Fusarium and Stachybotrys Obtained from Eastern Europe. Applied Environmental Microbiology, 32, 579-584.
[3] El-Magharaby, O.M.O., Saber, S.M., and Abdoul Nasr, M.B. (1992) Contamination of Pea (Pismsativuma L) Seeds by Fungi, Mycotoxins and Seeds by Fungi, Mycoyoxins and Resistance of Cultivar to Mycotoxin Accumulation. Sohag Pure and applied Science Bulletin, Faculty of Science, Egypt, 8, 137-155.
[4] William, B and Paulam, B.S. (1986) Activated Charcoal Preventing Unnecessary Death by Poisoning. J. Food Animal Prac., 2, 73-77.
[5] Al Seeni, M.N. (2011) Goji Extract as Antibacterial Agent and 5 Antioxidant on Roridin E Induced Hepato Toxicity in Malerat. J. Int. Environmental Application & Science, 6, 136-140.
[6] El-Sawi, N.M. (2003) Effect of Activated Charcoal on Trichoverrins (A & B) Toxin Administration on Rat Liver and Serum Protein. Journal of Applied Animal Research, 23, 175-184.
http://dx.doi.org/10.1080/09712119.2003.9706419
[7] Reitman, S. and Frankel, L. (1957) A Colorimetric Method for the Determination of Serum Glutamic Oxaloacetic and Glutamic Pyruvic Transaminases. American Journal of Clinical Pathology, 28, 56-63.
[8] Moss and Henderson, A.R. (1999) Clinical Enzymology. In: Burtis, C.A. and Ashwood, E.R., Eds., Tietz Textbook of Clinical Chemistry, 3rd Edition, Saunders, Philadephia, 617-677.
[9] Fringes, C.S., Ferdley, T.W., Dunn, R.T. and Queen, C.A. (1972) Improved Determination of Total Serum Lipids by the Sulfophos Vanillin Reaction. ClinChem., 18, 673-674.
[10] Miller, N.J., Rice-Evans, C., Davies, M.J., Gopinathan, V. and Milner, A. (1993) A Noval Method for Measuring Antioxidant Capacity and Its Application to Monitoring the Antioxidant Status in Premature Neonates. Clinical Science (London), 84, 407-412.
[11] Young, D.S. (1995) Effects of Drugs on Clinical Laboratory Test. 4th Edition, AACC Press, Washington.
[12] Beutler, B. and Cerami, A. (1987) Cachectin: More than a Tumor Necrosis Factor. New England Journal of Medicine, 316, 379-385.
http://dx.doi.org/10.1056/NEJM198702123160705
[13] Yang, G.H., Jarvis, B.B., Chung, Y.J. and Pestka, J.J. (2000) Apoptosis Induction by the Satratoxins and Other Trichothecene Mycotoxins: Relationship to ERK, p38 MAPK and SAPK/JNK Activation. Toxicology and Applied Pharmacology, 164, 149-160.
http://dx.doi.org/10.1006/taap.1999.8888
[14] Sudakin, D.L. (2003) Dietary Aflatoxin Exposure and Chemoprevention of Cancer: A Clinical Review. Clinical Toxicology, 41, 195-204.
http://dx.doi.org/10.1081/CLT-120019137
[15] Gao, X.M., Xu, Z.M. and Li, Z.W. (2000) Traditional Chinese Medicines. Peoples Health Publishing House, Beijing, 1832-1850.
[16] Gan, L. and Zhang, S.H. (2003) Effect of Lycium barbarum Polysaccharides on Antitumor Activity and Immune Function. Acta Nutrimenta Sinica, 25, 200-202.
[17] Luo, Q., Cai, Y., Yan, J., Sun, M. and Carke, H. (2004) Hypoglycemic and Hypolipidemic Effects and Antioxidant Activity of Fruit Extracts from Lycium barbarum. Life Sciences, 76, 137-149.
http://dx.doi.org/10.1016/j.lfs.2004.04.056
[18] Buck, W.B. (1991) Trichothecene Mycotoxins. In: Keeler, R.F. and Tu, A.T., Eds., Handbook of Natural Toxins, Vol. 6, Toxicology of Plant and Fungal Compounds, Marcel Deckker, Inc., New York, 523-555.
[19] Leung, H., Hung, A., Hui, A.C.F. and Vhan, T.Y.K. (2008) Warfarin Overdose Due to the Possible Effect of Lycium barbarum L. Food and Chemical Toxicology, 46, 1860-1862.
http://dx.doi.org/10.1016/j.fct.2008.01.008
[20] Liu, M., Tan, H., Zhang, X., Liu, Z., Cheng, Y., Wang, D. and Wang, F. (2014) Hematopoietic Effects and Mechanisms of Fufang E Jiaojiang on Radiotherapy and Chemotherapy Induced Myelosuppressed Mice. Journal of Ethnopharmacology, 4, 10-15.
[21] Zhong, Y., Shahidi, F. and Naczk, M. (2013) Phytochemicals and Health. Benefits of Goji Berries, 133-144.
[22] Reif, D.W. (1992) Ferritin as a Source of Iron for Oxidative Damage. Free Radical Biology and Medicine, 12, 417-427.
http://dx.doi.org/10.1016/0891-5849(92)90091-T
[23] ELsawi, N.M., Qusti, S.Y., Abo-Khatwa, A.N., Aldajani, W. and Ali, S.S. (2010) Biochemical Investigation on Roridin a Toxin and Thymoquinone Antidote on Mouse Liver. Journal of International Environmental Application & Science, 5, 703-712.
[24] Kontoghiorghes, G.J., Pattichi, K., Hadjigavriel, M. and Kolnagou, A. (2000) Transfusional Iron Overload and Chelation Therapy with Deferoxamine and Deferiprone (L1). Transfusion Science, 23, 211-223.
http://dx.doi.org/10.1016/S0955-3886(00)00089-8
[25] Amagase, H. and Nance, D.M. (2008) A Randomized Double-Blind, Placebo-Controlled, Clinical Study of the General Effects of a Standardized Lycium barbarum (Goji) Juice, Gochi. The Journal of Alternative and Complementary Medicine, 14, 403-412.
http://dx.doi.org/10.1089/acm.2008.0004                    eww141203lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文