跳至主要内容

Deterministic Parsing Model of the Compound Biological Effectiveness (CBE) Factor for Intracellular 10Boron Distribution in Boron Neutron Capture Therapy

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52141#.VIplS8nQrzE

Author(s)
Purpose: In defining the biological effects of the 10B(n, α)7Li neutron capture reaction, we have previously developed a deterministic parsing model to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron Capture Therapy (BNCT). In present paper, we demonstrate that the CBE factor is directly and unambiguously derivable by the new formula for any case of intracellular 10Boron (10B) distribution, which is founded on this model for tissues and tumor. Method: To determine the CBE factor, we derive the following new calculation formula founded on the deterministic parsing model with three con- stants, CBE0, F, n and the eigen value Nth/Nmax.

where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density in tissues and tumor. In order to determine these constants and the eigen values, iterative calculation technique was employed for the CEB factor and Nmax data set previously reported. Results and Conclusion: From the iterative calculation results, it is clear that the calculated CBE factor values obtained are almost identical to the original CBE factors and there is a good correlation between the original CBE factors and Nth/Nmax, when CBE0, F and n are given as 0.5, 8 and 3, respectively. These constants provide a better understanding of different types of intracellular10B distribution.
Cite this paper
Ishiyama, S. (2014) Deterministic Parsing Model of the Compound Biological Effectiveness (CBE) Factor for Intracellular 10Boron Distribution in Boron Neutron Capture Therapy. Journal of Cancer Therapy, 5, 1388-1398. doi: 10.4236/jct.2014.514140. 
 

[1] Bayanov, B., Belov, V., Kindyuk, V., Oparin, E. and Taskaev, S. (2004) Lithium Neutron Producting Target for BINP Accelerator-Based Neutron Source. Applied Radiation and Isotopes, 61, 817-821. http://dx.doi.org/10.1016/j.apradiso.2004.05.032
[2] Willis, C., Lenz, J. and Swenson, D. (2008) High-Power Lithium Target for Accelerator-Based BNCT. Proceedings of LINAC08, Victoria, MOP063, 223-225.
[3] Halfon, S., Paul, M., Arenshtam, A., Berkovits, D., Bisyakoev, M., Eliyahu, I., Feinberg, G., Hazenshprung, N., Kijel, D., Nagler, A. and Silverman, I. (2011) High Power Accelerator-Based Boron Neutron Capture with a Liquid Lithium Target and New Applications to Treatment of Infections Diseases. Applied Radiation and Isotopes, 69, 1654-1656.
http://dx.doi.org/10.1016/j.apradiso.2011.03.016
[4] Ishiyama, S., Baba, Y., Fujii, R., Nakamura, M. and Imahori, Y. (2012) In-Situ Vacuum Deposition Technique of Lithium on Neutron Production Target for BNCT. Nuclear Instruments and Methods in Physics Research, B288, 18-22. http://dx.doi.org/10.1016/j.nimb.2012.07.024
[5] Ishiyama, S., Baba, Y., Fujii, R., Nakamura, M. and Imahori, Y. (2012) Synthesis of Lithium Nitride for Neutron Producton Target of BNCT by In-Situ Lithium Deposition and Ion Implantation. Nuclear Instruments and Methods in Physics Research, B293, 42-47.
http://dx.doi.org/10.1016/j.nimb.2012.09.016
[6] Coderre, J.A., Morris, G.M., Micca, P.L., Fishe, C.D. and Ross, G.A. (1995) Comparative Assessment of Single-Dose and Fractional Boron Neutron Capture Therapy. Radiation Research, 166, 310-317. http://dx.doi.org/10.2307/3578951
[7] Bath, R.F., Soloway, A.H., Goodman, J.H., Gahbauer, R.A., Gupta, N., Blue, T.E., Yang, W. and Tjarks, W. (2004) Boron Neutron Capture Therapy of Brain Tumors: An Merging Therapeutic Modality 2. Neyrosurgery, 44, 433-451.
[8] Coderre, J.A. and Morris, G.M. (1999) The Irradiation Biology of Boron Neutron Capture Therapy. Radiation Research, 151, 1-18. http://dx.doi.org/10.2307/3579742
[9] Morrsi, G.M., Coderre, J.A., Hopewell, J.W., Micca, P.L. and Rezvani, M. (1994) Response of the Skin to Boron Neutron Capture Therapy with p-Boronopenylalanine or Borocaptate Sodium. Radiotherapy & Oncology, 39, 253-259.
[10] Fukuda, H., Kobayashi, T., Hiratsuka, J., et al. (1989) Estimation of Absorbed Dose in the Covering Skin of Human Melaoma Treated by Boron Capture Therapy. Pigment Cell Research, 2, 365-369. http://dx.doi.org/10.1111/j.1600-0749.1989.tb00222.x
[11] Kiger, J.L., Kiger III, W.S., Riley, K.J., Binns, P.J., Patel, H., Hopewell, J.W., Harling, O.K., Busse, P.M. and Coderre, J.A. (2008) Functional and Histological Changes in Rat Lung after Boron Neutron Capture Therapy. Radiation Research, 171, 60-69. http://dx.doi.org/10.1667/RR1266.1
[12] Suzuki, M., Masunaga, S., Kinachi, Y., Takagai, M., Sakurai, Y., Kobayashi, T. and Ono, K. (2000) The Effects of Boron Neutron Capture Therapy on Liver Tumors and Normal Hepatocytes in Mice. Japanese Journal of Cancer Research, 91, 1058-1064.
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00885.x
[13] Morris, G.M., Smith, D.R., Patel, H., et al. (2000) Boron Microlocalization in Oral Mucosal Tissue. British Journal of Cancer, 82, 1764-1771. http://dx.doi.org/10.1054/bjoc.2000.1148
[14] Horiguchi, H., Nakamura, T., Kumada, H., Yanagie, H., Suzuki, M. and Sagawa, H. (2011) Investigation of Irradiation Conditions for Recurrent Breast Cancer in JRR-4. Applied Radiation and Isotopes, 69, 1882-1884. http://dx.doi.org/10.1016/j.apradiso.2011.03.036
[15] Ulmer, W. (2014) A New Calculation Formula of the Nuclear Cross-Section of Therapeutic Protons. International Journal of Cancer Therapy and Oncology, 2, 1-13.
http://dx.doi.org/10.14319/ijcto.0202.11
[16] Imahori, Y., Ueda, S., Ohmori, Y., et al. (1998) Fluorine-18-Labeled Fluoroboronophenylalanine PET in Patients with Glioma. Journal of Nuclear Medicine, 39, 325-333.
[17] Wienhard, K., Herholz, K., Coenen, H.H., et al. (1991) Increased Amino Acid Tarransport into Brain Tumors Measured by PET of L-(2-18F) Fluorotyrosine. Journal of Nuclear Medicine, 32, 1338-1346.
[18] Patlak, C.S., Blasberg, R.G. and Fenstmacher, J.D. (1983) Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Journal of Cerebral Blood Flow & Metabolism, 3, 1-7. http://dx.doi.org/10.1038/jcbfm.1983.1                                       eww141212lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文