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Author(s)
Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands.
Department of Clinical Chemistry, Maasstad Hospital, Rotterdam, The Netherlands.
Department of Clinical Chemistry, Maasstad Hospital, Rotterdam, The Netherlands.
Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands.
Department of Clinical Chemistry, Maasstad Hospital, Rotterdam, The Netherlands.
Department of Clinical Chemistry, Maasstad Hospital, Rotterdam, The Netherlands.
Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands.
Background: According to most clinical guidelines
hypothyroidism should be excluded as a cause in the analysis of
euvolemic hyponatremia. Although this axiom has been well established in
clinical practice, relatively little evidence supports a relation
between hypothyroidism and hyponatremia. The current study was conducted
to prove an association between hypothyroidism and the occurrence of
hyponatremia. In addition, we sought to determine the effect of
L-thyroxine replacement therapy on plasma sodium levels. Methods: Data
from 2009 to 2011 were retrospectively reviewed. The database included
blood samples in which both thyroid function and plasma sodium were
determined. Regression analysis and ANOVA were performed to reveal an
association between hypothyroidism and hyponatremia. Results: Linear
regression analysis of plasma sodium on plasma TSH revealed no
relationship (R2 = 0.005). The corresponding gradient
belonging to the regression line was ﹣0.427 mmol/log plasma TSH (p =
0.22). No significant relation between plasma sodium and TSH
concentration could therefore be found. 32 hypothyroid patients who were
treated with L-thyroxine, were identified. No clear change in plasma
sodium could be discerned with regression analysis (0.707 mmol/L per
year, p = 0.147). Conclusion: Hypothyroidism is not a common cause of
hyponatremia. Screening for thyroid function does not seem warranted in
the initial analysis of a hyponatremic patient.
KEYWORDS
Cite this paper
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Alphen, A. (2014) Does Hypothyroidism Cause Hyponatremia?. Health, 6, 1453-1458. doi: 10.4236/health.2014.612179.
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