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Calcitonin Secretion under Insulin Hypoglycemia

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The increasing secretion of calcitonin and hypocalcemia under insulin hypoglycemia, induced with insulin injection (1 IU/100g), was established. Physiological mechanisms of the stimulating effect of insulin hypoglycemia on calcitonin secretion were studied in double-side adrenalectomized and pancreatectomized rats and under the blocking synaptic transmission in sympathetic ganglions or via peripheral cholino- and adreno-receptor structures. Insulin hypoglycemia didn’t expose the increasing secretion of calcitonin in rats under adrenalectomy and pancreatectomy. Ganglion-blocker pentamin (2.5 mg/100g body weight), blocker of M-cholino-receptors atropine (0.2 ml), α-adreno-blocker tropaphen (0.1 mg/100g), and β-adreno-blocker obzidan (0.1 mg/100g) evoked the inhibiting effect on calcitonin secretion in spite of simultaneously increasing of hypog-lycemia. Corticosteroids and, obviously, glucagon and also the tone of autonomic nervous system via peripheral M-cholinoreactive and α- and β-adrenoreactive structures take part in the activation of calcitonin secretion under insulin hypoglycemia.
Cite this paper
Moisa, S. and Nozdrachev, A. (2014) Calcitonin Secretion under Insulin Hypoglycemia. Open Journal of Endocrine and Metabolic Diseases, 4, 231-237. doi: 10.4236/ojemd.2014.411023. 
 

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http://dx.doi.org/10.1016/0026-0495(95)90079-9               eww141105lx
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