跳至主要内容

Calcitonin Secretion under Insulin Hypoglycemia

Read bull paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51178#.VFm9jWfHRK0

The increasing secretion of calcitonin and hypocalcemia under insulin hypoglycemia, induced with insulin injection (1 IU/100g), was established. Physiological mechanisms of the stimulating effect of insulin hypoglycemia on calcitonin secretion were studied in double-side adrenalectomized and pancreatectomized rats and under the blocking synaptic transmission in sympathetic ganglions or via peripheral cholino- and adreno-receptor structures. Insulin hypoglycemia didn’t expose the increasing secretion of calcitonin in rats under adrenalectomy and pancreatectomy. Ganglion-blocker pentamin (2.5 mg/100g body weight), blocker of M-cholino-receptors atropine (0.2 ml), α-adreno-blocker tropaphen (0.1 mg/100g), and β-adreno-blocker obzidan (0.1 mg/100g) evoked the inhibiting effect on calcitonin secretion in spite of simultaneously increasing of hypog-lycemia. Corticosteroids and, obviously, glucagon and also the tone of autonomic nervous system via peripheral M-cholinoreactive and α- and β-adrenoreactive structures take part in the activation of calcitonin secretion under insulin hypoglycemia.
Cite this paper
Moisa, S. and Nozdrachev, A. (2014) Calcitonin Secretion under Insulin Hypoglycemia. Open Journal of Endocrine and Metabolic Diseases, 4, 231-237. doi: 10.4236/ojemd.2014.411023. 
 

[1] Butakova (Moisa), S.S. and Nozdrachev, A.D. (2010) Effect of One-Time Injection of Calcitonin Preparations on Glucose and Calcium Level in Rats of Different Age Groups. Advances of Gerontology, 23, 93-97.
[2] Butakova (Moisa), S.S. and Nozdrachev, A.D. (2010) Effect of Calcitonin on the Type of Alimentary Hyperglycemia in Rats of Different Age and Sex. Advances of Gerontology, 23, 213-220.
[3] Butakova (Moisa), S.S. and Nozdrachev, A.D. (2010) Calcitonin-Glucoregulating Hormone. Vestik of Russian Military Medical Academy, 188-196.
[4] Moisa, S.S. and Nozdrachev, A.D. (2011) Mechanisms of Hyperglycemic Effect of Calcitonin. Bulletin of Experimental Biology and Medicine, 150, 320-323. http://dx.doi.org/10.1007/s10517-011-1132-3
[5] Moisa, S.S. and Nozdrachev, A.D. (2011) Mechanisms of Regulation of Calcium and Carbohydrate Metabolism (Monograph). LAP LAMBERT Academic Publishing GmbH & Co. KG, Saarbrucken, 319 p.
[6] Moisa, S.S. (2013) Calcitonin Contra-Insulin Action on Glucose Metabolism. Bulletin of Experimental Biology and Medicine, 156, 183-185. http://dx.doi.org/10.1007/s10517-013-2314-y
[7] Moisa, S.S. and Nozdrachev, A.D. (2013) One-Time Injection of Calcitonin Induces Glucose Intolerance in Children with the 1st Degree Obesity. Health, 5, 9-13. http://dx.doi.org/10.4236/health.2013.56A1002
[8] Moisa, S.S. and Nozdrachev, A.D. (2014) Calcitonin and Parathyrin Are Glucoregulating Hormones. Journal of Molecular and Genetic Medicine, 2, S1-S24. http://dx.doi.org/10.4172/1747-0862
[9] Butakova (Moisa), S.S. (2005) Calcitonin Secretion under the Different State of Carbohydrate Metabolism in Ontogenesis in Rats. Materials of the VII All-Russian Conference “Neuroendocrinology-2005”, St.-Petersburg, 25-27 April 2005, 36-37.
[10] Butakova (Moisa), S.S. (2007) Serum Calcitonin Activity and Total Calcium Content under the Different State of Carbohydrate Metabolism in Ontogenesis in Rats. Pavlov Institute of Physiology Russian Academy of Sciences. St.-Pe-tersburg, 7-9 October 2007, p. 32.
[11] Nozdrachev, A.D., Poliakov, E.L. and Bagaev, V.A. (2007) Experimental Surgery of the Laboratory Animals. Lan, St.-Petersburg, 125 and 130-132.
[12] Frank, H. and Kirberger, E. (1950) Eine Kolorimetrische Methode zur Bestimmung der “Wahren Glucose” und Galactose in 0.005 rm3. Blut. Biochem. Ztschr., 320, 359-367.
[13] Laljee, H.C.K., Smith, K.I. and Dorrington, K.J. (1967) The Assay of Human Thyrocalcitonin in Mice. Proccedings of the Symposium on Thyrocalcitonin and the C-Cells, London, 17-20 July 1967, 32-35.
[14] Selochnik, I.I., Briskin, A.I. and Antonova, E.E. (1978) Photoelectrocolorimetric Assay of Calcium Concentration in Serum by the Help of EDTA and Murexide. Chemical Pharmacological Journal, 12, 138-140.
[15] Usvatova, I.Y. and Pankov, Y.A. (1969) Fluorimetrical Methods of the Determination of Steroid Hormones in Biological Fluids. Medicine, Moscow, 38.
[16] Lineberry, M.P. and Waite, L.C. (1978) Calcitonin Responses in Intact and Adrenalectomized Rats. Life Sciences, 22, 511-518. http://dx.doi.org/10.1016/0024-3205(78)90432-0
[17] Shustov, S.B. and Halimov, Y.S. (2001) Functional and Topical Diagnostic in Endocrinology. Elbi, St.-Petersburg, 238 p.
[18] Zbucki, R.L., Dadan, I., Sawicki, B., Bialuk, I., Kosiozek, P., Winnicka, M. and Puchalski, Z. (2004) Propranolol Alters the Activity of Thyroid C-Cells in the Experimental Model of Hyperthyroidism in Rats. Proceedings of the 15 International Congress of the Polish Pharmacological Society, Poznan, 12-14 September 2004, 223.
[19] Ahren, B. (2000) Automatic Regulation of Islet Hormone Secretion—Implications for Health and Disease. Diabetologia, 43, 393-410. http://dx.doi.org/10.1007/s001250051322
[20] Butakova (Moisa), S.S. (2008) Calcitonin, a Modulater of Pancreas Secret Process. Thesis, Institute of Physiology of the Russian Academy of Sciences, St.-Petersburg, 26-27.
[21] Iaroshevskii, I.A., Darinskii, I.A. and Butakova (Moisa), S.S. (1989) Calcitonin Effect on Insulin and Glucagon Secretion by Panceas. Problems of Endocrinology, 35, 58-61.
[22] Moore, M.C., Lin, D.W., Colburn, C.A., Goldstein, R.E., Neal, D.W. and Cherrington, A.D. (1999) Insulin- and Glucagons-Independent Effects of Calcitonin Gene-Related Peptide in the Conscious Dog. Metabolism, 48, 603-610.http://dx.doi.org/10.1016/S0026-0495(99)90058-6
[23] Moisa, S.S. and Nozdrachev, A.D. (2013) Effect of Calcium-Regulating Hormones on Glucose Tolerance. Proceedings of Materials of the III International Research and Practice Conference: Science, Technology and Higher Education, Westwood, 16 October 2013, 516-522.
[24] Young, A.A., Wang, M.W. and Gedulin, B. (1995) Diabetogenic Effects of Salmon Calcitonin Are Attributable to Amylin-Like Activity. Metabolism, 44, 1581-1589.
http://dx.doi.org/10.1016/0026-0495(95)90079-9               eww141105lx
标签：

评论

发表评论

此博客中的热门博文

Electron Spin and Proton Spin in the Hydrogen and Hydrogen-Like Atomic Systems

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52202#.VIj7tMnQrzE Author(s) Stanisław Olszewski * Affiliation(s) Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland . ABSTRACT The mechanical angular momentum and magnetic moment of the electron and proton spin have been calculated semiclassically with the aid of the uncertainty principle for energy and time. The spin effects of both kinds of the elementary particles can be expressed in terms of similar formulae. The quantization of the spin motion has been done on the basis of the old quantum theory. It gives a quantum number n = 1/2 as the index of the spin state acceptable for both the electron and proton ...
发表评论
阅读全文

A Study on the Seismic Isolation Systems of Bridges with Lead Rubber Bearings

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52566#.VJt06cCAM4 Author(s)   Woo-Suk Kim , Dong-Joon Ahn , Jong-Kook Lee Affiliation(s) School of Architecture, Kumoh National Institute of Technology, Gumi, Republic of Korea . ABSTRACT This study consists of the development and presentation of example of seismic isolation system analysis and design for a continuous, 3-span, cast-in-place concrete box girder bridge. It is expected that example is developed for all Lead-Rubber Bearing (LRB) seismic isolation system on piers and abutments which placed in between super-structure and sub-structure. Design forces, displacements, and drifts are given distinctive consideration in...
发表评论
阅读全文

Effects of Karate Training on Basic Motor Abilities of Primary School Children

“You never attack first in karate” might be the best conclusion of karate, which is a martial art practiced typically without weapons. It’s reported that karate has a long history for several hundred years, but the modern karate was spread to the whole Japan from Okinawa in the early part of 20th century. Now it has become one of the most widely practiced martial art forms in the world. Usually, it’s divided into Kihon, Kata and Kumite. As for the beginners, Kihon is more suitable for them because it involves basic techniques. Due to karate consists of dynamic offensive and defensive techniques using all parts of the body to their maximum advantage, the best understanding of true karate practice is the perfection of oneself through the perfection of the art. It not only develops coordination, quickens reflexes, and builds stamina, but also develops composure, a clearer thought process, deeper insight into one’s mental capabilities, and more self-confidence. So many researchers stu...
发表评论
阅读全文