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The Effect of Direct Gas Fluorination on Medical Grade Poly(methyl methacrylate)

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Medical-grade poly(methyl methacrylate) (PMMA) is extensively employed in the fabrication of a variety of medical implants, including intraocular lenses (IOLs). However, a postoperative complication that leads to the failure of the implanted intraocular lenses has been recently identified. This process, termed calcification, occurs when calcium-containing deposits accumulate on the surface of the IOL. In this study direct gas fluorination was used to modify the surface of PMMA in an attempt to increase the service lifetime of the material in optical applications. PMMA discs exposed to a 20% fluorine/nitrogen gas mixture for 24 h were compared with untreated PMMA discs serving as control samples. Over time, both surface-fluorinated and untreated PMMA samples immersed in a simulated aqueous humour solution (SAHS) (pH 7.4, 35°C) were used to carry out in vitro studies. Attenuated total refractive Infrared spectroscopy (ATR-IR) Scanning electron microscopy (SEM), coupled with Energy dispersive X-ray analysis (EDX), showed that calcium-containing surface deposits were less abundant on surface-fluorinated PMMA compared with the control samples, indicating that the fluorinated surface was acting as a barrier to the deposits. Gravimetric analysis data showed that the decreased rate of diffusion compared with that of a control sample was due to the fluorinated surface.
Cite this paper
Ghatora, B. , Barton, S. , Foot, P. and Tate, P. (2014) The Effect of Direct Gas Fluorination on Medical Grade Poly(methyl methacrylate). Open Journal of Organic Polymer Materials, 4, 74-83. doi: 10.4236/ojopm.2014.44010. 
 

[1] Jaffe, M., Ophair, Z. and Pai, V. (2003) Biorelevant Characterization of Biopolymers. Thermochimica Acta, 396, 141-152. http://dx.doi.org/10.1016/S0040-6031(02)00524-5
[2] Kohnen, T. (1996) The Variety of Foldable Intraocular Lens Materials. Journal of Cataract Refractive Surgery, 22, 1255-1259. http://dx.doi.org/10.1016/S0886-3350(96)80079-4
[3] Werner, L. (2008) Calcification of hydrophilic Acrylic Intraocular Lenses. American Journal of Ophthalmology, 146, 341-343. http://dx.doi.org/10.1016/j.ajo.2008.05.011
[4] Werner, L. (2007) Causes of Intraocular Lens Opacification or Discoloration. Journal of Cataract Refractive Surgery, 33, 713-726. http://dx.doi.org/10.1016/j.jcrs.2007.01.015
[5] Dalas, E., Kallitsis, J.K. and Koutsoukos, P.G. (1991) Crystallization of Hydroxyapatite on Polymers. Langmuir, 7, 1822-1826.
[6] Bucher, P.J.M., Buchi, E.R. and Daicker, B.C. (1995) Dystrophic Calcification of an Implanted Hydrpxyethylmethacrylate Intraocular Lens. Arch Opthalmology, 113, 1431-1435.
http://dx.doi.org/10.1001/archopht.1995.01100110091031
[7] Olson, R.J., Caldwell, K.D. and Crandall, A.S. (1998) Intraoperative Crystallisation on the Intraocular Lens Surface. American Journal of Ophthalmology, 126, 177-184. http://dx.doi.org/10.1016/S0002-9394(98)00076-2
[8] Werner, L., Hunter, B., Stevens, S., Chew, J.J. and Mamalis, N. (2006) Role of Silicon Contamination on Calcification of Hydrophilic Acrylic Intraocular Lenses. American Journal of Ophthalmology, 141, 35-43.
http://dx.doi.org/10.1016/j.ajo.2005.08.045
[9] Dorey, M.W., Brownstein, S., Hill, V.E., Mathew, B., Botton, G., Kertes, P.J. and El-Defrawy, S. (2003) Proposed Pathogenesis for the Delayed Postoperative Opacification of the Hydroview Hydrogel Intraocular Lens. American Journal of Ophthalmology, 135, 591-598. http://dx.doi.org/10.1016/S0002-9394(02)02154-2
[10] Werner, L. (2007) Causes of Intraocular Lens Opacification or Discoloration. Journal of Cataract & Refractive Surgery, 33, 713-726. http://dx.doi.org/10.1016/j.jcrs.2007.01.015
[11] Nicolson, P.C. and Vogt, J. (2001) Soft Contact Lens Polymers: An Evolution. Biomaterials, 22, 3273-3283.
[12] Kharitonov, A.P. (2000) Practical Applications of the Direct Fluorination of Polymers. Journal of Fluorine Chemistry, 103, 123-127. http://dx.doi.org/10.1016/S0022-1139(99)00312-7
[13] Sandford, G. (2007) Elemental Fluorine in Organic Chemistry. Journal of Fluorine Chemistry, 128, 90-104.
http://dx.doi.org/10.1016/j.jfluchem.2006.10.019
[14] Kodjikian, L., Burillon, C., Chanloy, C., Bostvironnois, V., Pellon, G., Mari, E., Freney, J. and Roger, T. (2002) In Vivo Study of Bacterial Adhesion to Five Types of Intraocular Lenses. Investigative Ophthalmology & Visual Science, 43, 3717-3721.
[15] Du Toit, F.J., Sanderson, R.D., Engelbrecht, W.J. and Wagener, J.B. (1995) The Effect of Surface Fluorination on the Wettability of High Density Polyethylene. Journal of Fluorine Chemistry, 74, 43-48.
http://dx.doi.org/10.1016/0022-1139(94)03218-O
[16] Magee, T.R.A. and Richardson, P.S. (2007) Modelling Water Absorption of Pasta during Soaking. Journal of Food Engineering, 82, 600-607. http://dx.doi.org/10.1016/j.jfoodeng.2007.03.018
[17] Thomas, N.L. and Windle, A.H. (1980) A Deformation Model for Case II Diffusion. Polymer, 21, 1031.
http://dx.doi.org/10.1016/0032-3861(80)90316-X
[18] Moghbelli, E., Banyay, R. and Sue, H. (2014) Effect of Moisture Exposure on Scratch Resistance of PMMA. Tribology International, 69, 46-51. http://dx.doi.org/10.1016/j.triboint.2013.08.012
[19] Zainuddin, Z., Chirila, T.V., Hill, D.J.T. and Whittaker, A.K. (2005) Study of the Calcification of PHEMA Hydrogels Using a Two Compartment Permeation Cell. Journal of Molecular Structure, 739, 199-206.
[20] Hayes, L.J. (1976) Surface Energy Of Fluorinated Surfaces. Journal of Fluorine Chemistry, 8, 69-88.
http://dx.doi.org/10.1016/S0022-1139(00)82900-0
[21] Le Roux, J.D., Paul, D.R., Arendt, M.F., Yuan, Y. and Cabasso, I. (1994). Surface Fluorination of Poly(phenylene oxide) Composite Membranes: Part II. Characterization of the Fluorinated Layer. Journal of Membrane Science, 90, 37-53. http://dx.doi.org/10.1016/0376-7388(94)80032-4
[22] Buchen, S.Y., Cunanan, C.M., Gwon, A., Weinschenk, J.L., Gruber, L. and Knight, P.M. (2001) Assessing Intraocular Lens Calcification in an Animal Model. Journal of Cataract Refract Surgery, 27, 1473-1484.
http://dx.doi.org/10.1016/S0886-3350(01)00842-2
[23] Tilch, J., Schuster, M. and Fresenius, S. (2000) Determination of Palladium in Airborne Particulate Matter. Journal of Analytical Chemistry, 367, 450-453. http://dx.doi.org/10.1007/s002160000380
[24] Lai, J.Y., Chen, K.H., Hsu, W.M., Lee, T.H. and Lin, S.Y. (2005) Multiple Elements in the Deposits of Opacified Hydroview Intraocular Lens. American Journal of Ophthalmology, 139, 1123-1125.
http://dx.doi.org/10.1016/j.ajo.2004.11.052              eww141022lx
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