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Evaluation of Association between Chlamydophila pneumoniae and Atherosclerotic Plaques in Coronary Artery Disease Patients with Abnormal Angiography

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The role of Chlamydophila pneumoniae in pathogenesis of atherosclerosis is one of the most important discussions in coronary artery diseases. In this study, the relationship between C. pneumoniae seropositivity and atherosclerotic plaque was evaluated among two groups: one group with significant coronary stenosis and one group with normal coronary angiography. Serum C. pneumonia IgM and IgG were evaluated and compared in case and control groups. The seropositivity rates of IgM and IgG antibodies were not statistically differ between case and control groups, although the incidences of positivity were more in case group. The results of our study did not show a correlation between C. pneumonia infection and atherosclerotic plaque or coronary artery stenosis neither in acute nor in chronic infection. More precise studies are needed to clarify the probable inflammatory cascade that starts with C. pneumonia infection and lead to development of atherosclerotic plaque.
Cite this paper
Iranpour, D. , Abbasi, F. , Mirzayee, K. , Mohammadzadeh, N. , Raeisi, A. and Najafi, A. (2014) Evaluation of Association between Chlamydophila pneumoniae and Atherosclerotic Plaques in Coronary Artery Disease Patients with Abnormal Angiography. Health, 6, 2505-2509. doi: 10.4236/health.2014.618288. 
 

[1] Tufano, A., Di Capua, M., Coppola, A., Conca, P., Cimino, E., Cerbone, A.M. and Di Minno, G. (2012) The Infectious Burden in Atherothrombosis. Seminars in Thrombosis and Hemostasis, 38, 515-523.
http://dx.doi.org/10.1055/s-0032-1315759
[2] Luque, A., Turu, M.M., Rovira, N., Juan-Babot, J.O., Slevin, M. and Krupinski, J. (2012) Early Atherosclerotic Plaques Show Evidence of Infection by Chlamydia pneumoniae. Frontiers in Bioscience (Elite Edition), 4, 2423-2432.
http://dx.doi.org/10.2741/E554
[3] Al-Ghamdi, A., Jiman-Fatani, A.A. and El-Banna, H. (2011) Role of Chlamydia pneumoniae, Helicobacter pylori and Cytomegalovirus in Coronary Artery Disease. Pakistan Journal of Pharmaceutical Sciences, 24, 95-101.
[4] Di Pietro, M., Tramonti, A., De Santis, F., De Biase, D., Schiavoni, G., Filardo, S., Zagaglia, C. and Sessa, R. (2012) Analysis of Gene Expression in Penicillin G Induced Persistence of Chlamydia pneumoniae. Journal of Biological Regulators & Homeostatic Agents, 26, 277-284.
[5] Zhang, L., Li, X., Zhang, L., Wang, B., Zhang, T. and Ye, J. (2012) Chlamydophila (Chlamydia) Pneumoniae Infection Promotes Vascular Smooth Muscle Cell Adhesion and Migration through IQ Domain GTPase-Activating Protein 1. Microbial Pathogenesis, 53, 207-213.
http://dx.doi.org/10.1016/j.micpath.2012.07.005
[6] Zeman, K. (2006) Atherosclerosis and Infection. Vnitrni Lekarstvi, 52, 823-826.
[7] Birck, M.M., Pesonen, E., Odermarsky, M., Hansen, A.K., Persson, K., Frikke-Schmidt, H., Heegaard, P.M. and Liuba, P. (2011) Infection-Induced Coronary Dysfunction and Systemic Inflammation in Piglets Are Dampened in Hypercholesterolemic Milieu. American Journal of Physiology-Heart and Circulatory Physiology, 300, 1595-1601.
http://dx.doi.org/10.1152/ajpheart.01253.2010
[8] Rosenfeld, M.E. and Campbell, L.A. (2011) Pathogens and Atherosclerosis: Update on the Potential Contribution of Multiple Infectious Organisms to the Pathogenesis of Atherosclerosis. Thrombosis and Haemostasis, 106, 858-867.
http://dx.doi.org/10.1160/TH11-06-0392
[9] Kilic, Z.B., Poyraz, O. and Kilic, A.T. (2012) Investigation of Chlamydophila pneumoniae Seropositivity and Risk Factors in Patients with Atherosclerotic Vascular Disease in Sivas, Turkey. Mikrobiyoloji Bulteni, 46, 156-158.
[10] Eddens, T., Beaudoin, S., Steinberger, A., Little, C.S., Shell, D., Wizel, B., Balin, B. and Fresa-Dillon, K.L. (2012) Effect of Age and Vaccination on Extent and Spread of Chlamydia pneumoniae Infection in C57BL/6 Mice. Immunity & Ageing, 9, 11.
http://dx.doi.org/10.1186/1742-4933-9-11
[11] Chahine, M.N., Deniset, J., Dibrov, E., Hirono, S., Blackwood, D.P., Austria, J.A. and Pierce, G.N. (2011) Oxidized LDL Promotes the Mitogenic Actions of Chlamydia pneumoniae in Vascular Smooth Muscle Cells. Cardiovascular Research, 92, 476-483.
http://dx.doi.org/10.1093/cvr/cvr251
[12] Campbell, L.A., Puolakkainen, M., Lee, A., Rosenfeld, M.E., Garrigues, H.J. and Kuo, C.C. (2012) Chlamydia pneumoniae Binds to the Lectin-Like Oxidized LDL Receptor for Infection of Endothelial Cells. Microbes and Infection, 14, 43-49.
http://dx.doi.org/10.1016/j.micinf.2011.08.003
[13] Al-Bannawi, A., Al-Wesebai, K., Taha, S. and Bakhiet, M. (2011) Chlamydia pneumoniae Induces Chemokine Expression by Platelets in Patients with Atherosclerosis. Medical Principles and Practice, 20, 438-443.
http://dx.doi.org/10.1159/000324553
[14] Borel, N., Pospischil, A., Dowling, R.D., Dumrese, C., Gaydos, C.A., Bunk, S., Hermann, C., Ramirez, J.A. and Summersgill, J.T. (2012) Antigens of Persistent Chlamydia pneumoniae within Coronary Atheroma from Patients Undergoing Heart Transplantation. Journal of Clinical Pathology, 65, 171-177.
http://dx.doi.org/10.1136/jclinpath-2011-200270
[15] Halvorsen, D.S., Karlsen, J., Noto, A.T., Mathiesen, E.B., Njolstad, I., Gutteberg, T.J., Vorland, L.H. and Hansen, J.B. (2007) No Detectable Chlamydia pneumoniae and Cytomegalovirus DNA in Leukocytes in Subjects with Echolucent and Echogenic Carotid Artery Plaques. International Journal of Cardiology, 117, 388-394.
http://dx.doi.org/10.1016/j.ijcard.2006.05.025
[16] Dogra, J. (2012) Oral Azithromycin in Extended Dosage Schedule for Chronic, Subclinical Chlamydia pneumoniae Infection Causing Coronary Artery Disease: A Probable Cure in Sight? Results of a Controlled Preliminary Trial. International Journal of General Medicine, 5, 505-509.
http://dx.doi.org/10.2147/IJGM.S31625                      eww141017lx
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