跳至主要内容

Evaluation of Association between Chlamydophila pneumoniae and Atherosclerotic Plaques in Coronary Artery Disease Patients with Abnormal Angiography

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50545#.VECR5FfHRK0

The role of Chlamydophila pneumoniae in pathogenesis of atherosclerosis is one of the most important discussions in coronary artery diseases. In this study, the relationship between C. pneumoniae seropositivity and atherosclerotic plaque was evaluated among two groups: one group with significant coronary stenosis and one group with normal coronary angiography. Serum C. pneumonia IgM and IgG were evaluated and compared in case and control groups. The seropositivity rates of IgM and IgG antibodies were not statistically differ between case and control groups, although the incidences of positivity were more in case group. The results of our study did not show a correlation between C. pneumonia infection and atherosclerotic plaque or coronary artery stenosis neither in acute nor in chronic infection. More precise studies are needed to clarify the probable inflammatory cascade that starts with C. pneumonia infection and lead to development of atherosclerotic plaque.
Cite this paper
Iranpour, D. , Abbasi, F. , Mirzayee, K. , Mohammadzadeh, N. , Raeisi, A. and Najafi, A. (2014) Evaluation of Association between Chlamydophila pneumoniae and Atherosclerotic Plaques in Coronary Artery Disease Patients with Abnormal Angiography. Health, 6, 2505-2509. doi: 10.4236/health.2014.618288. 
 

[1] Tufano, A., Di Capua, M., Coppola, A., Conca, P., Cimino, E., Cerbone, A.M. and Di Minno, G. (2012) The Infectious Burden in Atherothrombosis. Seminars in Thrombosis and Hemostasis, 38, 515-523.
http://dx.doi.org/10.1055/s-0032-1315759
[2] Luque, A., Turu, M.M., Rovira, N., Juan-Babot, J.O., Slevin, M. and Krupinski, J. (2012) Early Atherosclerotic Plaques Show Evidence of Infection by Chlamydia pneumoniae. Frontiers in Bioscience (Elite Edition), 4, 2423-2432.
http://dx.doi.org/10.2741/E554
[3] Al-Ghamdi, A., Jiman-Fatani, A.A. and El-Banna, H. (2011) Role of Chlamydia pneumoniae, Helicobacter pylori and Cytomegalovirus in Coronary Artery Disease. Pakistan Journal of Pharmaceutical Sciences, 24, 95-101.
[4] Di Pietro, M., Tramonti, A., De Santis, F., De Biase, D., Schiavoni, G., Filardo, S., Zagaglia, C. and Sessa, R. (2012) Analysis of Gene Expression in Penicillin G Induced Persistence of Chlamydia pneumoniae. Journal of Biological Regulators & Homeostatic Agents, 26, 277-284.
[5] Zhang, L., Li, X., Zhang, L., Wang, B., Zhang, T. and Ye, J. (2012) Chlamydophila (Chlamydia) Pneumoniae Infection Promotes Vascular Smooth Muscle Cell Adhesion and Migration through IQ Domain GTPase-Activating Protein 1. Microbial Pathogenesis, 53, 207-213.
http://dx.doi.org/10.1016/j.micpath.2012.07.005
[6] Zeman, K. (2006) Atherosclerosis and Infection. Vnitrni Lekarstvi, 52, 823-826.
[7] Birck, M.M., Pesonen, E., Odermarsky, M., Hansen, A.K., Persson, K., Frikke-Schmidt, H., Heegaard, P.M. and Liuba, P. (2011) Infection-Induced Coronary Dysfunction and Systemic Inflammation in Piglets Are Dampened in Hypercholesterolemic Milieu. American Journal of Physiology-Heart and Circulatory Physiology, 300, 1595-1601.
http://dx.doi.org/10.1152/ajpheart.01253.2010
[8] Rosenfeld, M.E. and Campbell, L.A. (2011) Pathogens and Atherosclerosis: Update on the Potential Contribution of Multiple Infectious Organisms to the Pathogenesis of Atherosclerosis. Thrombosis and Haemostasis, 106, 858-867.
http://dx.doi.org/10.1160/TH11-06-0392
[9] Kilic, Z.B., Poyraz, O. and Kilic, A.T. (2012) Investigation of Chlamydophila pneumoniae Seropositivity and Risk Factors in Patients with Atherosclerotic Vascular Disease in Sivas, Turkey. Mikrobiyoloji Bulteni, 46, 156-158.
[10] Eddens, T., Beaudoin, S., Steinberger, A., Little, C.S., Shell, D., Wizel, B., Balin, B. and Fresa-Dillon, K.L. (2012) Effect of Age and Vaccination on Extent and Spread of Chlamydia pneumoniae Infection in C57BL/6 Mice. Immunity & Ageing, 9, 11.
http://dx.doi.org/10.1186/1742-4933-9-11
[11] Chahine, M.N., Deniset, J., Dibrov, E., Hirono, S., Blackwood, D.P., Austria, J.A. and Pierce, G.N. (2011) Oxidized LDL Promotes the Mitogenic Actions of Chlamydia pneumoniae in Vascular Smooth Muscle Cells. Cardiovascular Research, 92, 476-483.
http://dx.doi.org/10.1093/cvr/cvr251
[12] Campbell, L.A., Puolakkainen, M., Lee, A., Rosenfeld, M.E., Garrigues, H.J. and Kuo, C.C. (2012) Chlamydia pneumoniae Binds to the Lectin-Like Oxidized LDL Receptor for Infection of Endothelial Cells. Microbes and Infection, 14, 43-49.
http://dx.doi.org/10.1016/j.micinf.2011.08.003
[13] Al-Bannawi, A., Al-Wesebai, K., Taha, S. and Bakhiet, M. (2011) Chlamydia pneumoniae Induces Chemokine Expression by Platelets in Patients with Atherosclerosis. Medical Principles and Practice, 20, 438-443.
http://dx.doi.org/10.1159/000324553
[14] Borel, N., Pospischil, A., Dowling, R.D., Dumrese, C., Gaydos, C.A., Bunk, S., Hermann, C., Ramirez, J.A. and Summersgill, J.T. (2012) Antigens of Persistent Chlamydia pneumoniae within Coronary Atheroma from Patients Undergoing Heart Transplantation. Journal of Clinical Pathology, 65, 171-177.
http://dx.doi.org/10.1136/jclinpath-2011-200270
[15] Halvorsen, D.S., Karlsen, J., Noto, A.T., Mathiesen, E.B., Njolstad, I., Gutteberg, T.J., Vorland, L.H. and Hansen, J.B. (2007) No Detectable Chlamydia pneumoniae and Cytomegalovirus DNA in Leukocytes in Subjects with Echolucent and Echogenic Carotid Artery Plaques. International Journal of Cardiology, 117, 388-394.
http://dx.doi.org/10.1016/j.ijcard.2006.05.025
[16] Dogra, J. (2012) Oral Azithromycin in Extended Dosage Schedule for Chronic, Subclinical Chlamydia pneumoniae Infection Causing Coronary Artery Disease: A Probable Cure in Sight? Results of a Controlled Preliminary Trial. International Journal of General Medicine, 5, 505-509.
http://dx.doi.org/10.2147/IJGM.S31625                      eww141017lx
标签：

评论

发表评论

此博客中的热门博文

Does Immigration Promote the Investment of the Monopolistic Firm?

In the present paper, we examine the effect of increasing uncertainty of immigrants’ growth on the optimal timing of investment of a firm that has a monopolistic power over the labor market. It is revealed that when the uncertainty of immigrants’ growth is more than a threshold level, increasing uncertainty of immigrants’ growth accelerates the optimal timing of firms’ investment and enhances the economic growth, even if the uncertainty of immigrants’ growth is formulated by the geometric Brownian motion, which is in sharp contrast to the standard result that an increase in the uncertainty postpones the optimal timing. With an increase in the immigrants over the past ten years, workforces in the host countries have been growing significantly to the extent that the immigrants represent 70% of the increase in the workforce in Europe, and 47% in the United States as OECD indicates. In the present paper, we attempted to investigate the effect of increased uncertainty caused by the growi...
发表评论
阅读全文

Education Policy Implementation: A Mechanism for Enhancing Primary Education Development in Zanzibar

Education is one of the fundamental rights of individuals; therefore, the government of a country needs to develop and strengthen educational policy and quality as well as to ensure that everyone has equal access to basic education. The improvement of access and quality of education in the world is becoming as an essential factor in development, whereas the basic education (primary school), is acknowledged as a foundation of the higher educational development for every country. To fulfill this goal, governments introduce several policies and procedures; however, it requires some reforms and participation from the politician, policymakers, and other stakeholders to re-examine educational policy so that it can lead to multiplication and betterment of the reforms. Educational reforms actually focus on accountability. A positive educational development and reform is very challenging and needs more effort and strategy on how to use and utilize the resources effectively as such it can achie...
发表评论
阅读全文