Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50530#.VESenlfHRK0
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50530#.VESenlfHRK0
Author(s)
Introduction: Positive airway pressure (PAP) therapy
is the gold-standard for obstructive sleep apnea (OSA) management.
While it is known that PAP is efficacious for controlling breathing
events during sleep when it is worn at the right pressure for the amount
of time prescribed, there is less clear data on how well it improves
sleep quality. There are few studies that have examined the
effectiveness of PAP therapy on sleep quality. Methods: OSA participants
(n = 241) from a larger trial examining a PAP adherence were included.
Participants were provided with PAP instruction and followed at 2 months
and 4 months. PAP adherence was measured as the number of hours per
night at prescribed pressure, an objective measure of treatment
adherence. The Pittsburgh Sleep Quality Index (PSQI) was used as the
primary measure of sleep quality. Results: The PSQI was significantly
correlated with PAP adherence at both the 2-month and 4-month time
points, such that lower sleep quality was associated with lower PAP use.
This finding held for the sleep disturbance subscale of the PSQI. Over
55% of those using PAP therapy at the 4-month time point continued to
report significantly disturbed sleep. Discussion: This study shows that
PAP therapy does not appear to improve sleep quality to a degree that
would be expected. Over half of those patients using PAP therapy still
experienced disturbed sleep. Whether the disturbed sleep is directly
attributable to the PAP device itself or to disturbed sleep secondary to
uncontrolled OSA when PAP is not worn is worthy of further
investigation.
KEYWORDS
Cite this paper
Stepnowsky, C. , Zamora, T. and Edwards, C.
(2014) Does Positive Airway Pressure Therapy Result in Improved Sleep
Quality?. Health, 6, 2416-2424. doi: 10.4236/health.2014.618278.
| [1] | Loredo, J.S., Ancoli-Israel, S., Kim, E.J., Lim, W.J. and Dimsdale, J.E. (2006) Effect of Continuous Positive Airway Pressure versus Supplemental Oxygen on Sleep Quality in Obstructive Sleep Apnea: A Placebo-CPAP-Controlled Study. Sleep, 29, 564-571. |
| [2] |
McArdle, N. and Douglas, N.J.
(2001) Effect of Continuous Positive Airway Pressure on Sleep
Architecture in the Sleep Apnea-Hypopnea Syndrome: A Randomized
Controlled Trial. American Journal of Respiratory and Critical Care
Medicine, 164, 1459-1463. http://dx.doi.org/10.1164/ajrccm.164.8.2008146 |
| [3] |
Stepnowsky, C., Johnson, S.,
Dimsdale, J. and Ancoli-Israel, S. (2000) Sleep Apnea and Health-Related
Quality of Life in African-American Elderly. Annals of Behavioral
Medicine, 22, 116-120. http://dx.doi.org/10.1007/BF02895774 |
| [4] | Beebe, D.W., Groesz, L., Wells, C., Nichols, A. and McGee, K. (2003) The Neuropsychological Effects of Obstructive Sleep Apnea: A Meta-Analysis of Norm-Referenced and Case-Controlled Data. Sleep, 26, 298-307. |
| [5] | Findley, L.J., Suratt, P.M. and Dinges, D.F. (1999) Time-on-Task Decrements in “Steer Clear” Performance of Patients with Sleep Apnea and Narcolepsy. Sleep, 22, 804-809. |
| [6] | Aikens, J.E., Caruana-Montaldo, B., Vanable, P.A., Tadimeti, L. and Mendelson, W.B. (1999) MMPI Correlates of Sleep and Respiratory Disturbance in Obstructive Sleep Apnea. Sleep, 22, 362-369. |
| [7] | Grunstein, R.R., Stenlof, K., Hedner, J.A. and Sjostrom, L. (1995) Impact of Self-Reported Sleep-Breathing Disturbances on Psychosocial Performance in the Swedish Obese Subjects (SOS) Study. Sleep, 18, 635-643. |
| [8] |
Parish, J.M. and Lyng, P.J.
(2003) Quality of Life in Bed Partners of Patients with Obstructive
Sleep Apnea or Hypopnea after Treatment with Continuous Positive Airway
Pressure. Chest, 124, 942-947. http://dx.doi.org/10.1378/chest.124.3.942 |
| [9] |
Sullivan, C.E., Issa, F.G.,
Berthon-Jones, M. and Eves, L. (1981) Reversal of Obstructive Sleep
Apnoea by Continuous Positive Airway Pressure Applied through the Nares.
Lancet, 1, 862-865. http://dx.doi.org/10.1016/S0140-6736(81)92140-1 |
| [10] |
Loube, D.I., et al. (1999)
Indications for Positive Airway Pressure Treatment of Adult Obstructive
Sleep Apnea Patients: A Consensus Statement. Chest, 115, 863-866. http://dx.doi.org/10.1378/chest.115.3.863 |
| [11] |
Patel, S.R., White, D.P.,
Malhotra, A., Stanchina, M.L. and Ayas, N.T. (2003) Continuous Positive
Airway Pressure Therapy for Treating Sleepiness in a Diverse Population
with Obstructive Sleep Apnea. Archives of Internal Medicine, 163,
565-571. http://dx.doi.org/10.1001/archinte.163.5.565 |
| [12] |
Wright, J., Johns, R., Watt, I.,
Melville, A. and Sheldon, T. (1997) Health Effects of Obstructive Sleep
Apnoea and the Effectiveness of CPAP: A Systematic Review of the
Research Evidence. British Medical Journal, 314, 851-860. http://dx.doi.org/10.1136/bmj.314.7084.851 |
| [13] |
Stepnowsky Jr., C.J. and Moore,
P.J. (2003) Improving CPAP Use by Patients with the Sleep
Apnoea/Hypopnoea Syndrome (SAHS). Sleep Medicine Reviews, 7, 445-446. http://dx.doi.org/10.1053/smrv.2002.0289 |
| [14] | Barker, R., Zamora, T. and Stepnowsky, C. (2011) Accuracy of CPAP-Measured Apnea and Hypopneas. Sleep, 34, A327. |
| [15] | Berry, R.B., Kushida, C.A., Kryger, M.H., Soto-Calderon, H., Staley, B. and Kuna, S.T. (2012) Respiratory Event Detection by a Positive Airway Pressure Device. Sleep, 35, 361-367. |
| [16] |
Cilli, A., Uzun, R. and Bilge,
U. (2013) The Accuracy of Autotitrating CPAP-Determined Residual
Apnea-Hypopnea Index. Sleep Breath, 17, 189-193. http://dx.doi.org/10.1007/s11325-012-0670-x |
| [17] |
Veasey, S.C. (2006) Obstructive
Sleep Apnea: Re-Evaluating Our Index of Severity. Sleep Medicine, 7,
5-6. http://dx.doi.org/10.1016/j.sleep.2005.08.012 |
| [18] |
Nieto, F.J., Young, T.B., Lind,
B.K., Shahar, E., Samet, J.M., Redline, S., et al. (2000) Association of
Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large
Community-Based Study. Sleep Heart Health Study. JAMA, 283, 1829-1836. http://dx.doi.org/10.1001/jama.283.14.1829 |
| [19] |
Hers, V., Liistro, G., Dury, M.,
Collard, P., Aubert, G. and Rodenstein, D.O. (1997) Residual Effect of
nCPAP Applied for Part of the Night in Patients with Obstructive Sleep
Apnoea. European Respiratory Journal, 10, 973-976. http://dx.doi.org/10.1183/09031936.97.10050973 |
| [20] | Sforza, E. and Lugaresi, E. (1995) Daytime Sleepiness and Nasal Continuous Positive Airway Pressure Therapy in Obstructive Sleep Apnea Syndrome Patients: Effects of Chronic Treatment and 1-Night Therapy Withdrawal. Sleep, 18, 195-201. |
| [21] | Yang, Q., Phillips, C.L., Melehan, K.L., Rogers, N.L., Seale, J.P. and Grunstein, R.R. (2006) Effects of Short-Term CPAP Withdrawal on Neurobehavioral Performance in Patients with Obstructive Sleep Apnea. Sleep, 29, 545-552. |
| [22] |
Wickwire, E.M., Smith, M.T.,
Birnbaum, S. and Collop, N.A. (2010) Sleep Maintenance Insomnia
Complaints Predict Poor CPAP Adherence: A Clinical Case Series. Sleep
Medicine, 11, 772-776. http://dx.doi.org/10.1016/j.sleep.2010.03.012 |
| [23] |
Nguyen, X.L., Chaskalovic, J.,
Rakotonanahary, D. and Fleury, B. (2010) Insomnia Symptoms and CPAP
Compliance in OSAS Patients: A Descriptive Study Using Data Mining
Methods. Sleep Medicine, 11, 777-784. http://dx.doi.org/10.1016/j.sleep.2010.04.008 |
| [24] |
Pieh, C., Bach, M., Popp, R.,
Jara, C., Cronlein, T., Hajak, G., et al. (2013) Insomnia Symptoms
Influence CPAP Compliance. Sleep & Breath, 17, 99-104. http://dx.doi.org/10.1007/s11325-012-0655-9 |
| [25] |
Tunis, S.R., Stryer, D.B. and
Clancy, C.M. (2003) Practical Clinical Trials: Increasing the Value of
Clinical Research for Decision Making in Clinical and Health Policy.
JAMA, 290, 1624-1632. http://dx.doi.org/10.1001/jama.290.12.1624 |
| [26] |
Stepnowsky, C., Edwards, E.,
Zamora, T., Barker, R. and Agha, Z. (2013) Patient Perspective on Use of
an Interactive Website for Sleep Apnea. International Journal of
Telemedicine and Applications, 2013, Article ID: 239382. http://dx.doi.org/10.1155/2013/239382 |
| [27] | AASM (1999) Sleep-Related Breathing Disorders in Adults: Recommendations for Syndrome Definition and Measurement Techniques in Clinical Research. The Report of an American Academy of Sleep Medicine Task Force. Sleep, 22, 667-689. |
| [28] |
Buysse, D.J., Reynolds, C.F.,
Monk, T.H., Berman, S.R. and Kupfer, D.J. (1989) The Pittsburgh Sleep
Quality Index: A New Instrument for Psychiatric Practice and Research.
Psychiatry Research, 28, 193-213. http://dx.doi.org/10.1016/0165-1781(89)90047-4 |
| [29] | Buysse, D.J., Reynolds, C.F., Monk, T.H., Hoch, C.C., Yeager, A.L. and Kupfer, D.J. (1991) Quantification of Subjective Sleep Quality in Healthy Elderly Men and Women Using the Pittsburgh Sleep Quality Index (PSQI). Sleep, 14, 331-338. |
| [30] |
Buysse, D.J., Reynolds, C.F.,
Monk, T.H., Berman, S.R. and Kupfer, D.J. (1989) Pittsburgh Sleep
Quality Index (PSQI). http://www.sleep.pitt.edu/content.asp?id=1484&subid=2316 |
| [31] | Johns, M.W. (1991) A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale. Sleep, 14, 540-545. |
| [32] |
Radloff, L.S. (1977) The CES-D
Scale: A Self-Report Depression Scale for Research in the General
Population. Applied Psychological Measurement, 1, 385-401. http://dx.doi.org/10.1177/014662167700100306 |
| [33] | Andresen, E.M., Malmgren, J.A., Carter, W.B. and Patrick, D.L. (1994) Screening for Depression in Well Older Adults: Evaluation of a Short Form of the CES-D (Center for Epidemiologic Studies Depression Scale). American Journal of Preventive Medicine, 10, 77-84. |
| [34] |
Bardwell, W.A., Ancoli-Israel,
S. and Dimsdale, J.E. (2007) Comparison of the Effects of Depressive
Symptoms and Apnea Severity on Fatigue in Patients with Obstructive
Sleep Apnea: A Replication Study. Journal of Affective Disorders, 97,
181-186. http://dx.doi.org/10.1016/j.jad.2006.06.013 |
| [35] |
Jackson, M.L., Stough, C.,
Howard, M.E., Spong, J., Downey, L.A. and Thompson, B. (2010) The
Contribution of Fatigue and Sleepiness to Depression in Patients
Attending the Sleep Laboratory for Evaluation of Obstructive Sleep
Apnea. Sleep Breath, 15, 439-445. http://dx.doi.org/10.1007/s11325-010-0355-2 |
| [36] |
Wells, R.D., Day, R.C., Carney,
R.M., Freedland, K.E. and Duntley, S.P. (2004) Depression Predicts
Self-Reported Sleep Quality in Patients with Obstructive Sleep Apnea.
Psychosomatic Medicine, 66, 692-697. http://dx.doi.org/10.1097/01.psy.0000140002.84288.e1 |
| [37] |
Rush, A.J., Armitage, R.,
Gillin, J.C., Yonkers, K.A., Winokur, A., Moldofsky, H., et al. (1998)
Comparative Effects of Nefazodone and Fluoxetine on Sleep in Outpatients
with Major Depressive Disorder. Biological Psychiatry, 44, 3-14. http://dx.doi.org/10.1016/S0006-3223(98)00092-4 |
| [38] |
Gillin, J.C., Rapaport, M.,
Erman, M.K., Winokur, A. and Albala, B.J. (1997) A Comparison of
Nefazodone and Fluoxetine on Mood and on Objective, Subjective, and
Clinician-Rated Measures of Sleep in Depressed Patients: A Double-Blind,
8-Week Clinical Trial. Journal of Clinical Psychiatry, 58, 185-192. http://dx.doi.org/10.4088/JCP.v58n0502 |
| [39] |
Stepnowsky, C.J., Palau, J.J.,
Zamora, T., Ancoli-Israel, S. and Loredo, J.S. (2011) Fatigue in Sleep
Apnea: The Role of Depressive Symptoms and Self-Reported Sleep Quality.
Sleep Medicine, 12, 832-837. http://dx.doi.org/10.1016/j.sleep.2011.07.004 eww141020lx |
评论
发表评论