Dobutamine Infusion and Absence of Pulmonary Hypertension Are Associated with Decreased Mortality in a Cohort of 249 Patients with Cardiogenic Shock
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Author(s)
Objective: Prognostic analysis of 249 patients
admitted for cardiogenic shock (CS) of various origins. Background:
Little is known about prognosis of CS from non-ischemic cardiomyopathy.
Methods: Retrospective monocentric study of patients referred to an ICU
during 2 years. Results: Despite aggressive management including
intra-aortic balloon pump (31%), extra-renal replacement therapy (36%),
extra-corporeal life support (8%), and catecholamine infusion (97%),
in-hospital mortality was 46%. Toxic CS or CS related to deficiency
carried a better outcome (mortality 5%). Post-myocardial infarction or
post-cardiac arrest CS was associated with higher mortality. In the
multivariate analyses, only SAPS II (OR 1.037; 1.013 - 1.056; p =
0.0001), pulmonary hypertension (OR 4.8; 1.3 - 17; p = 0.02),
extra-renal replacement therapy (OR 2.9; 1.3 - 6; p = 0.006), and
dobutamine infusion (OR 0.44; 0.2 - 0.96; p = 0.04) were significantly
associated with in-hospital mortality. Conclusion: Dobutamine infusion
was associated with a better outcome. Higher SAPS II, pulmonary
hypertension, and extra-renal replacement therapy were associated with
increased in-hospital mortality.
KEYWORDS
Cite this paper
Champion, S. , Gaüzère, B. , Vandroux, D. , Bouchet,
B. , Drouet, D. and Lefort, Y. (2014) Dobutamine Infusion and
Absence of Pulmonary Hypertension Are Associated with Decreased
Mortality in a Cohort of 249 Patients with Cardiogenic Shock. Health, 6, 2408-2415. doi: 10.4236/health.2014.618277.
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