Analytical Solutions of Nonlinear Differential Equations in the Mathematical Model for Inactivation of Nitric Oxide by Rat Cerebellar Slices
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Author(s)
A mathematical model for the inactivation of nitric
oxide by rat cerebellar slices under non-steady state condition has been
analyzed. This diffusion-inactivation model was used to estimate the
kinetics of NO consumption by the rat cerebellar slices. He’s Homotopy
perturbation method is used to solve the first order nonlinear
differential equations which describe the concentrations given by net of
diffusion and inactivation by the slices. Analytical expressions for
the concentration of nitric oxide have been derived for all values of
parameters. The obtained analytical results are compared with the
simulation results (Matlab/Scilab program) and are found to be in good
agreement.
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Cite this paper
Mehala, N. and Rajendran, L. (2014) Analytical
Solutions of Nonlinear Differential Equations in the Mathematical Model
for Inactivation of Nitric Oxide by Rat Cerebellar Slices. American Journal of Analytical Chemistry, 5, 908-919. doi: 10.4236/ajac.2014.514099.
| [1] |
Coleman, J.W. (2001) Nitric
Oxide in Immunity and Inflammation. International Immunopharmacology, 1,
1397-1406. http://dx.doi.org/10.1016/S1567-5769(01)00086-8 |
| [2] |
Furchgott, R.F. (1999)
Endothelium-Derived Relaxing Factor: Discovery, Early Studies and
Identification as Nitric Oxide. Bioscience Reports, 19, 235-251. http://dx.doi.org/10.1023/A:1020537506008 |
| [3] |
Garthwaite, J. (2008) Concepts
of Neural Nitric Oxide-Mediated Transmission. European Journal of
Neuroscience, 27, 2783-2802. http://dx.doi.org/10.1111/j.1460-9568.2008.06285.x |
| [4] |
Steinert, J.R., Chernova, T. and
Forsythe, I.D. (2010) Nitric Oxide Signalling in Brain Function,
Dysfunction, and Dementia. Neuroscientist, 16, 435-452. http://dx.doi.org/10.1177/1073858410366481 |
| [5] |
Thomas, D.D., Ridnour, L.A.,
Isenberg, J.S., et al. (2008) The Chemical Biology of Nitricoxide:
Implications in Cellular Signaling. Free Radical Biology & Medicine,
45, 18-31. http://dx.doi.org/10.1016/j.freeradbiomed.2008.03.020 |
| [6] | Hou, Y.C., Janczuk, A. and Wang, P.G. (1999) Current Trends in the Development of Nitric Oxide Donors. Current Pharmaceutical Design, 5, 417-441. |
| [7] |
Palmer, R.M., Ferrige, A.G. and
Moncada, S. (1987) Nitric Oxide Release Accounts for the Biological
Activity of Endothelium-Derived Relaxing Factor. Nature, 327, 524-526. http://dx.doi.org/10.1038/327524a0 |
| [8] |
Ignarro, L.J., Buga, G.M., Wood,
K.S., Byrns, R.E. and Chaudhuri, G. (1987) Endothelium Derived Relaxing
Factor Produced and Released from Artery and Vein Is Nitricoxide.
Proceedings of the National Academy of Science of USA, 84, 9265-9269. http://dx.doi.org/10.1073/pnas.84.24.9265 |
| [9] |
Garthwaite, J., Charles, S.L.
and Chess-Williams, R. (1988) Endothelium-Derived Relaxing Factor
Release on Activation of NMDA Receptors Suggests Role as Intercellular
Messenger in the Brain. Nature, 336, 385-388. http://dx.doi.org/10.1038/336385a0 |
| [10] |
Marletta, M.A., Yoon, P.S.,
Iyengar, R., Leaf, C.D. and Wishnok, J.S. (1988) Macrophage Oxidation of
L-Arginine to Nitrite and Nitrate: Nitric Oxide Is an Intermediate.
Biochemistry, 27, 8706-8711. http://dx.doi.org/10.1021/bi00424a003 |
| [11] |
Nowicki, J.P., Duval, D.,
Poignet, H. and Scatton, B. (1991) Nitric Oxide Mediates Neuronal Death
after Focal Ischemia in the Mouse. European Journal of Pharmacology,
204, 339-340. http://dx.doi.org/10.1016/0014-2999(91)90862-K |
| [12] |
Trifiletti, R.R. (1992)
Neuroprotective Effects of NG-Nitro-L-Arginine in Focal Stroke in the
7-Day-Old Rat. European Journal of Pharmacology, 218, 197-198. http://dx.doi.org/10.1016/0014-2999(92)90168-4 |
| [13] |
Marletta, M.A. (1989) Nitric
Oxide: Biosynthesis and Biological Significance. Trends in Biochemical
Sciences, 14, 488-492. http://dx.doi.org/10.1016/0968-0004(89)90181-3 |
| [14] |
East, S.J. and Garthwaite, J.
(1991) NMDA Receptor Activation in Rat Hippocampus Induces Cyclic GMP
Formation through the L-Arginine-Nitric Oxide Pathway. Neuroscience
Letters, 123, 17-19. http://dx.doi.org/10.1016/0304-3940(91)90147-L |
| [15] |
Garthwaite, J., Garthwaite, G.,
Palmer, R.M.J. and Moncada, S. (1989) NMDA Receptor Activation Induces
Nitric Oxide Synthesis from Arginine in Rat Brain Slices. European
Journal of Pharmacology, 172, 413-416. http://dx.doi.org/10.1016/0922-4106(89)90023-0 |
| [16] |
Southam, E., East, E.J. and
Garthwaite, J. (1991) Excitatory Amino Acid Receptors Coupled to the
Nitric Oxide/Cyclic GMP Pathway in Rat Cerebellum during Development.
Journal of Neurochemistry, 56, 2072-2081. http://dx.doi.org/10.1111/j.1471-4159.1991.tb03468.x |
| [17] |
Arnold, W.P., Mittal, C.K.,
Katsuki, S. and Murad, F. (1977) Nitric Oxide Activates Guanylate
Cyclase and Increases Guanosine 3’:5’-Cyclic Monophosphate Levels in
Various Tissue Preparations. Proceedings of the National Academy of
Sciences of the United States of America, 74, 3203-3207. http://dx.doi.org/10.1073/pnas.74.8.3203 |
| [18] | Miki, N., Kawabe, Y. and Kuriyama, K. (1977) Activation of Cerebral Guanylate Cyclase by Nitric Oxide. Biochemical and Biophysical Research Communications, 75, 851-856. |
| [19] | Hall, C.N. and Garthwaite, J. (2005) Trans-Synaptic Signaling by Nitric Oxide. In: Ludwig, M., Ed., Dendritic Neurotransmitter Release, Springer, New York, 283-300. |
| [20] | Moncada, S., Palmer, R.M. and Higgs, E.A. (1991) Nitric Oxide: Physiology, Pathophysiology, and Pharmacology. Pharmacological Reviews, 43, 109-142. |
| [21] | Nathan, C. (1992) Nitric Oxide as a Secretory Product of Mammalian Cells. Journal of the Federation of American Societies for Experimental Biology, 6, 3051-3064. |
| [22] | Hall, C.N. and Garthwaite, J. (2006) Inactivation of Nitric Oxide by Rat Cerebellar Slices. Journal of Physiology, 577, 549-567. |
| [23] |
Vazquez-Leal, H.,
Filobello-Nino, U., Yildirim, A., Hernandez-Martinez, L.,
Castaneda-Sheissa, R., Sanchez-Orea, J., Molinar-Solis, J.E. and
Diaz-Sanchez, A. (2012) Transient and DC Approximate Expressions for
Diode Circuits. IEICE Electronics Express, 9, 522-530. http://dx.doi.org/10.1587/elex.9.522 eww141010lx |
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