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A Single-Center Experience of Systemic Onset Juvenile Idiopathic Arthritis at a Tertiary Hospital in Jeddah, Saudi Arabia

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Background and Objective: Systemic-onset juvenile idiopathic arthritis (JIA) is a major and prevalent subset of arthritis among children and it has a broad spectrum of clinical presentation, course and prognosis. This study described the clinical presentation of systemic-onset JIA in a Saudi-based cohort. Methods: A retrospective chart review was performed of the medical records of children with systemic-onset JIA who were followed up at King Abdul Aziz University Hospital, Jeddah, between January 1997 and December 2013. Patients’ files were reviewed for demographic, clinical, and paraclinical data, which were analyzed using the statistical Package for the Social Sciences. Results: We included 20 patients of both genders (8 boys and 12 girls). The mean age of disease onset was 7 (4.5) years. The most common presenting symptoms were fever (100%), arthritis (100%), and rash (55%). Hepatomegaly (5%), abdominal (5%) and pulmonary manifestations (3%) were less frequent manifestations. Most patients had high white blood cell counts (50%), elevated erythrocyte sedimentation rates (80%) and C-reactive protein levels (90%). The interval between onset of symptoms and diagnosis was 9.4 (12.5) weeks. Patients were treated with non-steroidal anti-inflammatory drugs, methotrexate, steroids, anti-tumor necrosis agents, and disease-modifying anti-rheumatic drugs. Bone marrow biopsy was conducted to exclude malignancy in 20% of the patients. Conclusion: Saudi children with systemic-onset JIA present with prolonged fever and arthritis (mainly oligoarticular rather than polyarticular). Physicians should be aware of the presentation of systemic-onset JIA in our setting in order to make prompt diagnosis and treatment decisions as early as possible. Carful follow-up of febrile patients is paramount to reaching the diagnosis early and initiating treatment.
Cite this paper
Garout, W. and Muzaffer, M. (2014) A Single-Center Experience of Systemic Onset Juvenile Idiopathic Arthritis at a Tertiary Hospital in Jeddah, Saudi Arabia. Open Journal of Rheumatology and Autoimmune Diseases, 4, 212-218. doi: 10.4236/ojra.2014.44029. 
 

[1] Yeh, T.L., Huang, F.Y., Shyur, S.D., Chen, T.L., Lee, C.S. and Huang, D.T. (2010) Juvenile Idiopathic Arthritis Presenting with Prolonged Fever. Journal of Microbiology, Immunology and Infection, 43, 169-174.
http://dx.doi.org/10.1016/S1684-1182(10)60027-8
[2] Tsai, H.Y., Lee, J.H., Yu, H.H., Wang, L.C., Yang, Y.H. and Chiang, B.L. (2012) Initial Manifestations and Clinical Course of Systemic Onset Juvenile Idiopathic Arthritis: A Ten-Year Retrospective Study. Journal of the Formosan Medical Association, 111, 542-549.
http://dx.doi.org/10.1016/j.jfma.2011.06.013
[3] Gurion, R., Lehman, T.J. and Moorthy, L.N. (2012) Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment. International Journal of Inflammation, 2012, Article ID: 271569.
http://dx.doi.org/10.1155/2012/271569
[4] Cimaz, R., Von Scheven, A. and Hofer, M. (2012) Systemic-Onset Juvenile Idiopathic Arthritis: The Changing Life of a Rare Disease. Swiss Medical Weekly, 142, w13582.
[5] De Benedetti, F. and Schneider, R. (2010) Systemic Juvenile Idiopathic Arthritis. In: Textbook of Pediatric Rheumatology, 6th Edition, Saunders.
[6] Schneider, R. and Laxer, R.M. (2008) Chap. 3: Systemic Juvenile Idiopathic Arthritis. In: Cimaz, R. and Lehman, T.J.A., Eds., Handbook of Systemic Autoimmune Diseases (Series Editor: Asherson, R.A.). Vol. 6: Pediatrics in Systemic Autoimmune Diseases, 35-54.
[7] Cassidy, J.T., Levinson, J.E., Bass, J.C., Baum, J., Brewer Jr., E.J., Fink, C.W., Hanson, V., Jacobs, J.C., Masi, A.T., Schaller, J.G., et al. (1986) A Study of Classification Criteria for a Diagnosis of Juvenile Rheumatoid Arthritis. Arthritis & Rheumatism, 29, 274-281.
http://dx.doi.org/10.1002/art.1780290216
[8] Vastert, S.J., Kuis, W. and Grom, A.A. (2009) Systemic JIA: New Developments in the Understanding of the Pathophysiology and Therapy. Best Practice & Research Clinical Rheumatology, 23, 655-664.
http://dx.doi.org/10.1016/j.berh.2009.08.003
[9] Batthish, M., Schneider, R., Ramanan, A.V., Achonu, C., Young, N.L. and Feldman, B.M. (2005) What Does “Active Disease” Mean? Patient and Parent Perceptions of Disease Activity in the Systemic Arthritis Form of Juvenile Idiopathic Arthritis (SO-JIA). Rheumatology (Oxford), 44, 796-799.
http://dx.doi.org/10.1093/rheumatology/keh597
[10] Bahabri, S., Al-Sewairi, W., Al-Mazyad, A., Karrar, A., Al-Ballaa, S., El-Ramahai, K., et al. (1997) Juvenile Rheumatoid Arthritis: The Saudi Experience. Annals of Saudi Medicine, 17, 413-418.
[11] Singh-Grewal, D., Schneider, R., Bayer, N. and Feldman, B.M. (2006) Predictors of Disease Course and Remission in Systemic Juvenile Idiopathic Arthritis: Significance of Early Clinical and Laboratory Features. Arthritis & Rheumatism, 54, 1595-1601.
http://dx.doi.org/10.1002/art.21774
[12] Shishov, M., Henrickson, M., Burgos-Vargas, R., Rubio-Pérez, N., Baca, V., Romero-Feregrino, R, Solís-Vallejo, E., Huang, B., Grom, A.A. and Lovell, D.J. (2007) Systemic Features and Early Prognostic Factors in Hispanic and Non-Hispanic Children from the United States of America and Mexico with Systemic Juvenile Idiopathic Arthritis. Clinical and Experimental Rheumatology, 25, 907-914.
[13] Spiegel, L.R., Schneider, R., Lang, B.A., Birdi, N., Silverman, E.D., Laxer, R.M., et al. (2000) Early Predictors of Poor Functional Outcome in Systemic-Onset Juvenile Rheumatoid Arthritis: A Multicenter Cohort Study. Arthritis & Rheumatism, 43, 2402-2409.                   eww141023lx
http://dx.doi.org/10.1002/1529-0131(200011)43:11<2402::AID-ANR5>3.0.CO;2-C
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