跳至主要内容

Comparison of the Efficacy of Two Commercial Coccidicidal Compounds on Experimentally Infected Dogs

Read full paper at:
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52702#.VKDJLcCAM4

The aim of the present study was to compare the coccidicidal efficacy of two commercial compounds for artificially infected dogs. Eighteen cocccidia-free dogs, male and female aged between 2 and 4 months old, were infected each with 20,000 Cystoisospora oocists cultured under laboratory conditions. When the poppies showed high counts of oocysts per gramm (OPG) (McMaster method), they were divided into 3 groups (G). G1 was treated with a compound named One® (Lab. Bio Zoo) containing 150 mg of toltrazuril/tablet, administered daily/5days dosing 1 tablet per 10 kg b.w. G2 received Giacoccide® (Pet’s Pharma) containing 250 mg of sulfadimetoxine and 165 mg of dimetridazole dosing 1 tablet per 10 kg b.w. twice a day for 10 days. G3 served as an untreated control. The puppies were coprologically monitored on Days 0, 3, 5, 10, 15, 20 and 25 to determine the percentage of OPG. Efficacy was measured based on the OPG reduction on treated animals relative to the untreated control. The results indicated an efficacy for compound One of 78.4%, 100%, 100%, 100%, 100% and 100%, for Days 3, 5, 10, 15, 20 and 25, respectively and for Giacoccide 40.6%, 45.5%, 47.4%, 65.9%, 90.4% and 92.7%, for Days 3, 5, 10, 15, 20 and 25, respectively. No statistical difference was observed on the weight of the treated puppies (p < 0.764), but the control group was statistically different to the treated ones (p < 0.014). It was concluded that compound One showed greater efficacy than Giacoccide for the treatment of canine coccidiosis in artificially infected dogs.
Cite this paper
Ibarra-Velarde, F. , Vera-Montenegro, Y. , Saldaña-Hernández, N. and Ochoa-Galván, P. (2014) Comparison of the Efficacy of Two Commercial Coccidicidal Compounds on Experimentally Infected Dogs. Pharmacology & Pharmacy, 5, 1163-1170. doi: 10.4236/pp.2014.513127.

[1] Dubey, J.P., Lindsay, D.S. and Lappin, M.R. (2009) Toxoplasmosis and Other Intestinal Coccidial Infections in Cats and Dogs. Veterinary Clinics of North America: Small Animal Practice, 39, 1009-1034.
http://dx.doi.org/10.1016/j.cvsm.2009.08.001
[2] Gates, M.C. and Nolan, T.J. (2009) Endoparasite Prevalence and Recurrence across Different Age Groups of Dogs and Cats. Veterinary Parasitology, 166, 153-158.
http://dx.doi.org/10.1016/j.vetpar.2009.07.041
[3] Lucio-Forster, A. and Bowman, D.D. (2001) Prevalence of Fecal-Borne Parasites Detected by Centrifugal Flotation in Feline Samples from Two Shelters in Upstate New York. Journal of Feline Medicine and Surgery, 13, 300-303.
http://dx.doi.org/10.1016/j.jfms.2010.12.013
[4] Lappin, M.R. (2005) Enteric Protozoal Diseases. Veterinary Clinics of North America: Small Animal Practice, 35, 81-88. http://dx.doi.org/10.1016/j.cvsm.2004.08.004
[5] Companion Animal Parasite Council (2014) http://www.capcvet.org/capc-recommendations/coccidia
[6] Lloyd, S. and Smith, J. (2001) Activity of Toltrazuril and Diclazuril against Isospora Species in Kittens and Puppies. Veterinary Record, 148, 509-511.
http://dx.doi.org/10.1136/vr.148.16.509
[7] Daugschies, A., Mundt, H.C. and Letkova, V. (2000) Toltrazuril Treatment of Cystoisosporosis in Dogs under Experimental and Field Conditions. Parasitology Research, 86, S797-S799.
http://dx.doi.org/10.1007/s004360000217
[8] Marchiondo, A.A., Holdsworth, P.A., Green, P., Blagburn, B.L. and Jacobs, D.E. (2007) World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guidelines for Evaluating the Efficacy of Parasiticides for the Treatment, Prevention and Control of Flea and Tick Infestation on Dogs and Cats. Veterinary Parasitology, 145, 332-344.
http://dx.doi.org/10.1016/j.vetpar.2006.10.028
[9] Little, S.E., Johnson, E.M. and Lewis, D. (2009) Prevalence of Intestinal Parasites in Pet Dogs in the United States. Veterinary Parasitology, 166, 144-152.
http://dx.doi.org/10.1016/j.vetpar.2009.07.044
[10] Myoung-Seok, K., Jong-Hwan, L., Youn-Huan, H., Byung-Kwon, P., In-Bae, S. and Hyo-In, Y. (2010) Plasma Disposition of Toltrazuril and Its Metabolites, Toltrazuril Sulfoxide and Toltrazuril Sulfone, in Rabbits after Oral Administration. Veterinary Parasitology, 169, 51-56.
http://dx.doi.org/10.1016/j.vetpar.2009.12.011
[11] Charles, S.D., Chopade, H.M., Ciszewski, D.K., Arther, R.G., Settje, T.L. and Reinemeyer, C.R. (2007) Safety of 5% Ponazuril (Toltrazuril Sulfone) Oral Suspension and Efficacy against Naturally Acquired Cystoisospora ohioensis-Like Infection in Beagle Puppies. Parasitology Research, 169, 51-56.
[12] Reinemeyer, C.R., Lindsay, D.S., Mitchell, S.M., Mundt, H.C., Charles, S.D., Arther, R.G. and Settje, T.L. (2007) Development of Experimental Cystoisospora canis Infection Models in Beagle Puppies and Efficacy Evaluation of 5% Ponazuril (Toltrazuril Sulfone) Oral Suspensión. Parasitology Research, 101, 129-136.
http://dx.doi.org/10.1007/s00436-007-0620-x
[13] Petry, G., Kruedewagen, E., Kampkoetter, A. and Krieger, K. (2011) Efficacy of Emodepside/Toltrazuril Suspension (Procox® Oral Suspension for Dogs) against Mixed Experimental Isospora felis/Isospora rivolta Infection in Cats. Parasitology Research, 109, S29-S36.
http://dx.doi.org/10.1007/s00436-011-2400-x
[14] Altreuther, G., Gasda, N., Schroeder, I., Joachim, A., Settje, T., Schimmel, A., Hutchens, D. and Krieger, K.J. (2011) Efficacy of Emodepside plus Toltrazuril Suspension (Procox® Oral Suspension for Dogs) against Prepatent and Patent Infection with Isospora canis and Isospora ohioensis-Complex in Dogs. Parasitology Research, 109, S9-S20.
http://dx.doi.org/10.1007/s00436-011-2398-0
The aim of the present study was to compare the coccidicidal efficacy of two commercial compounds for artificially infected dogs. Eighteen cocccidia-free dogs, male and female aged between 2 and 4 months old, were infected each with 20,000 Cystoisospora oocists cultured under laboratory conditions. When the poppies showed high counts of oocysts per gramm (OPG) (McMaster method), they were divided into 3 groups (G). G1 was treated with a compound named One® (Lab. Bio Zoo) containing 150 mg of toltrazuril/tablet, administered daily/5days dosing 1 tablet per 10 kg b.w. G2 received Giacoccide® (Pet’s Pharma) containing 250 mg of sulfadimetoxine and 165 mg of dimetridazole dosing 1 tablet per 10 kg b.w. twice a day for 10 days. G3 served as an untreated control. The puppies were coprologically monitored on Days 0, 3, 5, 10, 15, 20 and 25 to determine the percentage of OPG. Efficacy was measured based on the OPG reduction on treated animals relative to the untreated control. The results indicated an efficacy for compound One of 78.4%, 100%, 100%, 100%, 100% and 100%, for Days 3, 5, 10, 15, 20 and 25, respectively and for Giacoccide 40.6%, 45.5%, 47.4%, 65.9%, 90.4% and 92.7%, for Days 3, 5, 10, 15, 20 and 25, respectively. No statistical difference was observed on the weight of the treated puppies (p < 0.764), but the control group was statistically different to the treated ones (p < 0.014). It was concluded that compound One showed greater efficacy than Giacoccide for the treatment of canine coccidiosis in artificially infected dogs.
Cite this paper
Ibarra-Velarde, F. , Vera-Montenegro, Y. , Saldaña-Hernández, N. and Ochoa-Galván, P. (2014) Comparison of the Efficacy of Two Commercial Coccidicidal Compounds on Experimentally Infected Dogs. Pharmacology & Pharmacy, 5, 1163-1170. doi: 10.4236/pp.2014.513127.

[1] Dubey, J.P., Lindsay, D.S. and Lappin, M.R. (2009) Toxoplasmosis and Other Intestinal Coccidial Infections in Cats and Dogs. Veterinary Clinics of North America: Small Animal Practice, 39, 1009-1034.
http://dx.doi.org/10.1016/j.cvsm.2009.08.001
[2] Gates, M.C. and Nolan, T.J. (2009) Endoparasite Prevalence and Recurrence across Different Age Groups of Dogs and Cats. Veterinary Parasitology, 166, 153-158.
http://dx.doi.org/10.1016/j.vetpar.2009.07.041
[3] Lucio-Forster, A. and Bowman, D.D. (2001) Prevalence of Fecal-Borne Parasites Detected by Centrifugal Flotation in Feline Samples from Two Shelters in Upstate New York. Journal of Feline Medicine and Surgery, 13, 300-303.
http://dx.doi.org/10.1016/j.jfms.2010.12.013
[4] Lappin, M.R. (2005) Enteric Protozoal Diseases. Veterinary Clinics of North America: Small Animal Practice, 35, 81-88. http://dx.doi.org/10.1016/j.cvsm.2004.08.004
[5] Companion Animal Parasite Council (2014) http://www.capcvet.org/capc-recommendations/coccidia
[6] Lloyd, S. and Smith, J. (2001) Activity of Toltrazuril and Diclazuril against Isospora Species in Kittens and Puppies. Veterinary Record, 148, 509-511.
http://dx.doi.org/10.1136/vr.148.16.509
[7] Daugschies, A., Mundt, H.C. and Letkova, V. (2000) Toltrazuril Treatment of Cystoisosporosis in Dogs under Experimental and Field Conditions. Parasitology Research, 86, S797-S799.
http://dx.doi.org/10.1007/s004360000217
[8] Marchiondo, A.A., Holdsworth, P.A., Green, P., Blagburn, B.L. and Jacobs, D.E. (2007) World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guidelines for Evaluating the Efficacy of Parasiticides for the Treatment, Prevention and Control of Flea and Tick Infestation on Dogs and Cats. Veterinary Parasitology, 145, 332-344.
http://dx.doi.org/10.1016/j.vetpar.2006.10.028
[9] Little, S.E., Johnson, E.M. and Lewis, D. (2009) Prevalence of Intestinal Parasites in Pet Dogs in the United States. Veterinary Parasitology, 166, 144-152.
http://dx.doi.org/10.1016/j.vetpar.2009.07.044
[10] Myoung-Seok, K., Jong-Hwan, L., Youn-Huan, H., Byung-Kwon, P., In-Bae, S. and Hyo-In, Y. (2010) Plasma Disposition of Toltrazuril and Its Metabolites, Toltrazuril Sulfoxide and Toltrazuril Sulfone, in Rabbits after Oral Administration. Veterinary Parasitology, 169, 51-56.
http://dx.doi.org/10.1016/j.vetpar.2009.12.011
[11] Charles, S.D., Chopade, H.M., Ciszewski, D.K., Arther, R.G., Settje, T.L. and Reinemeyer, C.R. (2007) Safety of 5% Ponazuril (Toltrazuril Sulfone) Oral Suspension and Efficacy against Naturally Acquired Cystoisospora ohioensis-Like Infection in Beagle Puppies. Parasitology Research, 169, 51-56.
[12] Reinemeyer, C.R., Lindsay, D.S., Mitchell, S.M., Mundt, H.C., Charles, S.D., Arther, R.G. and Settje, T.L. (2007) Development of Experimental Cystoisospora canis Infection Models in Beagle Puppies and Efficacy Evaluation of 5% Ponazuril (Toltrazuril Sulfone) Oral Suspensión. Parasitology Research, 101, 129-136.
http://dx.doi.org/10.1007/s00436-007-0620-x
[13] Petry, G., Kruedewagen, E., Kampkoetter, A. and Krieger, K. (2011) Efficacy of Emodepside/Toltrazuril Suspension (Procox® Oral Suspension for Dogs) against Mixed Experimental Isospora felis/Isospora rivolta Infection in Cats. Parasitology Research, 109, S29-S36.
http://dx.doi.org/10.1007/s00436-011-2400-x
[14] Altreuther, G., Gasda, N., Schroeder, I., Joachim, A., Settje, T., Schimmel, A., Hutchens, D. and Krieger, K.J. (2011) Efficacy of Emodepside plus Toltrazuril Suspension (Procox® Oral Suspension for Dogs) against Prepatent and Patent Infection with Isospora canis and Isospora ohioensis-Complex in Dogs. Parasitology Research, 109, S9-S20.
http://dx.doi.org/10.1007/s00436-011-2398-0               eww141229lx
标签：

评论

发表评论

此博客中的热门博文